题目: Two novel alkaloids from the South China Sea marine sponge Dysidea sp. 

作者: ShenRen ,WeiMa ,TunhaiXu ,XiupingLin ,HaoYin ,BinYang ,Xue-FengZhou ,Xian-WenYang ,,KyungJinLee ,QipinGao andYonghong, Liu LijuanLong* 

刊物: Journal of Antibiotics ，（IF=1.28，IV区）

刊号: 2010,63: 699-701 

摘要: Marine sponge is the oldest and simplest multicellular animal that is widely spread on earth, and has been proved to be a particularly fruitful source of new compounds with novel structures and bioactivities. 1 The genus Dysidea (order Dictyoceratida, family Dysideidae) is known as a rich source of diverse classes of secondary metabolites.2 About 300 compounds, such as terpenoids,3–5 steroids,6,7 peptides8,9 and polychlorinated metabolites,10–12 were isolated from the genus Dysidea. Many of them have significant bioactivities, such as antibacterial, 9,13–15 anti-inflammatory16 and cytotoxic.17,18 In our study of the bioactive compounds from marine sponges, two new (1, 2) and two known (3, 4) alkaloids were isolated from the marine sponge Dysidea sp. The structures of two new metabolites were elucidated by interpretation of spectroscopic data. Compound 1 carried a thiomethylated imidazolium nucleus similar to that found in dragmacidonamine A (5)19 and L-ovithiol A disulfide (6).20 Compound 2 was a protonated dimethylamine group constituting the b-carboline alkaloid, similar to the partial structure of denticin C (7).21 In this paper, the isolation, structure elucidation and biological activity of these compounds are described.