题目: Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate 

作者: Huang, H.; Yao, Y.; He, Z.; Yang, T.; Ma, J.; Tian, X.; Li, Y.; Huang, C.; Chen, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* 

刊物: J. Nat. Prod.，（IF=2.872，III区）

刊号: 2011, 74:2122-2127 

摘要: Four new β-carboline alkaloids, designated marinacarbolines A–D (1–4), two new indolactam alkaloids, 13-N-demethyl-methylpendolmycin (5) and methylpendolmycin-14-O-α-glucoside (6), and the three known compounds 1-acetyl-β-carboline (7), methylpendolmycin (8), and pendolmycin (9) were obtained from the fermentation broth of Marinactinospora thermotolerans SCSIO 00652, a new actinomycete belonging to the family Nocardiopsaceae. Their structures were elucidated by extensive MS and 1D and 2D NMR spectroscopic data analyses. The structure of compound 1 was further confirmed by single-crystal X-ray crystallography. The new compounds 1–6 were inactive against a panel of eight tumor cell lines (IC50 > 50 μM) but exhibited antiplasmodial activities against Plasmodium falciparumlines 3D7 and Dd2, with IC50 values ranging from 1.92 to 36.03 μM.