您的位置:首页>论文发表>2013
2013

秦启伟研究团队在《Virus Research》发表文章

副标题:

时间:2013-12-26  作者:LMB  来源:文本大小:【 |  | 】  【打印

题目: Identification and characterization of a tumor necrosis factor receptor like protein encoded by Singapore grouper iridovirus 

作者: Xiaohong Huang, Youhua Huang, Jia Cai, Shina Wei, Ren Gao, Qiwei Qin* 

刊物Virus Research,IF=2.745II区)

刊号: 2013,178:340-348 

摘要: Virus encoded tumor necrosis factor receptors (TNFRs) have been demonstrated to facilitate virus to escape from apoptosis or other host immune response for viral replication. Singapore grouper iridovirus (SGIV), a large DNA virus which belongs to genus Ranavirus, is a major pathogen resulting in heavy economic losses to grouper aquaculture. Here, SGIV ORF096 (VP96) encoding a putative homolog of TNFR was identified and characterized. Multiple sequence alignment indicated that SGIV-VP96 contained two extracellular cysteine-rich domains (CRDs) with conserved four or six cysteine residues, but lacked the transmembrane domain at the C-terminus. SGIV-VP96 was identified as an early (E) gene and localized in the cytoplasm in transfected or infected cells. Overexpression of SGIV-VP96 in vitro enhanced cell proliferation, and improved cell survival against SGIV infection. Furthermore, virus infection induced apoptosis and caspase-3 activity were inhibited in SGIV-VP96 expressing FHM cells compared to the control cells. Taken together, our results suggested that SGIV might utilize virus encoded TNFR like genes to modulate the host apoptotic response for effective virus replication. 

相关附件
相关文档
Copyright    中国科学院热带海洋生物资源与生态重点实验室    版权所有
地址:广东省广州市新港西路164号  邮编:510301   粤ICP备05007992号    粤公网安备44011502001245号
电话:020-89023101  传真:86-20-84451672  Email:liujuan@scsio.ac.cn