您的位置:首页>论文发表>2014
2014

漆淑华研究团队在《marine drugs》发表两篇论文

副标题:

时间:2014-12-24  作者:LMB  来源:文本大小:【 |  | 】  【打印

No.1

题目: Cytotoxic Polyketides from the Deep-Sea-Derived Fungus Engyodontium album DFFSCS021

作者:  Qifeng Yao, Jie Wang, Xiaoyong Zhang, Xuhua Nong, Xinya Xu, Shuhua Qi*

刊物:marine drugs,(IF=3.978II区)

  :  2014,12(12):5902-5915

摘要: Eight new chromones, engyodontiumones A–H (1–8), and three new phenol derivatives (9–11) together with eight known polyketides (12–19) were isolated from the deep-sea-derived fungus Engyodontium album DFFSCS021. Their structures were identified by extensive spectroscopic analysis. Compounds 8 and 16 showed significant selective cytotoxicity against human histiocytic lymphoma U937 cell line with IC50 values of 4.9 and 8.8 μM, respectively. In addition, this is the first time to report that 8, 15 and 16 had mild antibacterial activity against Escherichia coli and Bacillus subtilis, and 15 showed potent antilarval activity against barnacle Balanus amphitrite larval settlement.

 

No.2

题目: Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus

作者:  Xuhua Nong, Yifei Wang, Xiaoyong Zhang, Muping Zhou, Xinya Xu, Shuhua Qi*

刊物:marine drugs,(IF=3.978II区)

刊号:  2014,12(12):6113-6124

摘要: Seventeen lactones including eight territrem derivatives (1–8) and nine butyrolactone derivatives (9–17) were isolated from a marine-derived fungus Aspergillus terreus SCSGAF0162 under solid-state fermentation of rice. Compounds 1–3 and 9–10 were new, and their structures were elucidated by spectroscopic analysis. The acetylcholinesterase inhibitory activity and antiviral activity of compounds 1–17 were evaluated. Among them, compounds 1 and 2 showed strong inhibitory activity against acetylcholinesterase with IC50 values of 4.2 ± 0.6, 4.5 ± 0.6 nM, respectively. This is the first time it has been reported that 3, 6, 10, 12 had evident antiviral activity towards HSV-1 with IC50 values of 16.4 ± 0.6, 6.34 ± 0.4, 21.8 ± 0.8 and 28.9 ± 0.8 μg·mL1, respectively. Antifouling bioassay tests showed that compounds 1, 11, 12, 15 had potent antifouling activity with EC50 values of 12.9 ± 0.5, 22.1 ± 0.8, 7.4 ± 0.6, 16.1 ± 0.6 μg·mL1 toward barnacle Balanus amphitrite larvae, respectively.

 

相关附件
相关文档
Copyright    中国科学院热带海洋生物资源与生态重点实验室    版权所有
地址:广东省广州市新港西路164号  邮编:510301   粤ICP备05007992号
电话:020-89023101  传真:86-20-84451672  Email:liujuan@scsio.ac.cn