题目: Cyclopentane-condensed Chromones from Marine-derived Fungus Penicillium oxalicum

作者:  Jie Bao, Xiaoyong Zhang, Jiejie Dong, Xinya Xu, Xuhua Nong, Shuhua Qi*

刊物：Bioorganic & Medicinal Chemistry Letters, (IF=2.331, III区)

刊号:  2014,43:837-839

摘要: Four dihydrothiophene-condensed chromones including two new compounds oxalicumones D–E (1–2) and known oxalicumones A–B (3–4), along with five other known chromones were isolated from a culture broth of the marine gorgonian-associated fungus Penicillium oxalicum SCSGAF 0023. The structures of 1–2 were elucidated by spectroscopic analysis. Eleven derivatives 3a–3i and 4a–4b were obtained from the acylation of 3 and 4, respectively. Compounds 1–4, 3a–3e, 3g–3h, and 4b showed significant cytotoxicity against several carcinoma cell lines with IC50 6 10 lM. And their structure–bioactivity relationship was discussed.