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张长生研究团队在《Journal of Natural Products》发表论文

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时间:2014-12-24  作者:LMB  来源:文本大小:【 |  | 】  【打印

题目: Indimicins A–E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032

作者:  Wenjun Zhang , Liang Ma(共同第一), Sumei Li, Zhong Liu, Yuchan Chen , Haibo Zhang, Guangtao Zhang, Qingbo Zhang, Xinpeng Tian , Chengshan Yuan , Si Zhang , Weimin Zhang , and Changsheng Zhang *

刊物:Journal of Natural Products, IF=3.285, III区)

 :  2014,77(8):1887-1892

摘要: Five new bisindole alkaloids, indimicins AE (15), bearing a unique 1′,3′-dimethyl-2′-hydroindole moiety, were isolated from the marine-derived Streptomyces sp. SCSIO 03032, along with two new compounds, lynamicins F and G (6 and 7). Their planar structures were elucidated by detailed interpretation of their MS and NMR spectroscopic data, and the absolute configurations were determined by X-ray crystallographic analysis (for 1), comparison of CD spectra (for 24), and quantum chemical calculations (for 5). Indimicin B (2) exhibited moderate cytotoxic activity toward the MCF-7 cell line.

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