题目: Indimicins A–E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032

作者:  Wenjun Zhang , Liang Ma(共同第一), Sumei Li, Zhong Liu, Yuchan Chen , Haibo Zhang, Guangtao Zhang, Qingbo Zhang, Xinpeng Tian , Chengshan Yuan , Si Zhang , Weimin Zhang , and Changsheng Zhang *

刊物：Journal of Natural Products, （IF=3.285, III区）

刊 号:  2014,77(8):1887-1892

摘要: Five new bisindole alkaloids, indimicins A−E (1−5), bearing a unique 1′,3′-dimethyl-2′-hydroindole moiety, were isolated from the marine-derived Streptomyces sp. SCSIO 03032, along with two new compounds, lynamicins F and G (6 and 7). Their planar structures were elucidated by detailed interpretation of their MS and NMR spectroscopic data, and the absolute configurations were determined by X-ray crystallographic analysis (for 1), comparison of CD spectra (for 2−4), and quantum chemical calculations (for 5). Indimicin B (2) exhibited moderate cytotoxic activity toward the MCF-7 cell line.