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张长生研究团队在《Organic Letters》发表论文

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时间:2014-12-24  作者:LMB  来源:文本大小:【 |  | 】  【打印

题目: Acyclic Congeners from Actinoalloteichus cyangriseus Provide Insights into Cyclic Bipyridine Glycoside Formation

作者:  Peng Fu,Yiguang Zhu(共同第一),Xiangui Mei,Yi Wang,Haijian Jia,Changsheng Zhang*and Weiming Zhu*

刊物:Organic Letters, (IF=6.142, II)

刊号:  2014,16(16),4264-4267

摘要: Inactivation of the O-methyltransferase gene crmM of Actinoalloteichus cyanogriseus WH1-2216-6 led to a mutant that produced three new acyclic bipyridine glycosides, cyanogrisides EG (13). Further chemical analysis of the wild strain yielded 1 and another new analogue, cyanogriside H (4). Compounds 14 possess a skeleton consisting of a 2,2′-bipyridine and a Dquinovose or L-rhamnose sugar moiety. Cyanogriside G (3) was considered to be a key biosynthetic intermediate of the cyclic bipyridine glycosides cyanogrisides AD. Compounds 2 and 3 showed cytotoxicities against HCT116 and HL-60 cells, and compounds 1 and 4 were cytotoxic on K562 cells.

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