题目: Acyclic Congeners from Actinoalloteichus cyangriseus Provide Insights into Cyclic Bipyridine Glycoside Formation

作者:  Peng Fu,Yiguang Zhu(共同第一),Xiangui Mei,Yi Wang,Haijian Jia,Changsheng Zhang*and Weiming Zhu*

刊物：Organic Letters, (IF=6.142, II区)

刊号:  2014,16(16),4264-4267

摘要: Inactivation of the O-methyltransferase gene crmM of Actinoalloteichus cyanogriseus WH1-2216-6 led to a mutant that produced three new acyclic bipyridine glycosides, cyanogrisides E−G (1−3). Further chemical analysis of the wild strain yielded 1 and another new analogue, cyanogriside H (4). Compounds 1−4 possess a skeleton consisting of a 2,2′-bipyridine and a Dquinovose or L-rhamnose sugar moiety. Cyanogriside G (3) was considered to be a key biosynthetic intermediate of the cyclic bipyridine glycosides cyanogrisides A−D. Compounds 2 and 3 showed cytotoxicities against HCT116 and HL-60 cells, and compounds 1 and 4 were cytotoxic on K562 cells.