漆淑华研究团队在《Tetrahedron 》发表论文
副标题:
题目: Eight linear peptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020 |
作者: Xiao Liang, Xiao-Yong Zhang, Xu-Hua Nong, Jie Wang, Zhong-Hui Huang, Shu-Hua Qi* |
刊物: Tetrahedron |
刊号:2016,72(22):3092-3097 |
摘要: Eight new linear peptides, simplicilliumtides AeH (1e8) were isolated from a culture broth of the deepsea-derived fungal strain Simplicillium obclavatum EIODSF 020. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were determined by Marfey’s method. Compounds 1e2 are linear tetrapeptides possessing a 2-aminobenzoic acid residue. Compounds 3e8 are acetylated linear tri- or di-peptides. Their antifouling, antibacterial, cytotoxic, and acetylcholinesterase inhibiting activities were evaluated. Compound 4 showed strong antifouling activity against Bugula neritina larvae settlement. And 1, 5, 7 and 8 showed weak cytotoxicity towards human leukemia HL-60 or K562 cell line. |
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