2017
鞠建华研究团队在《Organic Letters》发表论文
副标题:
时间:2017-10-20 作者:LMB 来源:文本大小:【大 | 中 | 小】 【打印】
题目: Elucidating the Sugar Tailoring Steps in the Cytorhodin Biosynthetic
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作者: Chun Gui, Xuhua Mo, Yu-Cheng Gu, Jianhua Ju*
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刊物: Organic Letters
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年卷期页: 2017,19(20):5617-5620
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摘要:Anthracycline antitumor cytorhodins X and Y feature a rare 9α-glycoside and 7-dexoy-aglycone. Characterization of the cytorhodin gene cluster from Streptomyces sp. SCSIO 1666 through gene inactivations and metabolite analyses reveals three glycosyltransferases (GTs) involved in the sugar tailoring steps. The duo of CytG1 and CytL effects C-7 glycosylation with L-rhodosamine whereas the iterative GT CytG3 and CytW similarly modifies both C-9 and C-10 positions. CytG2 also acts iteratively by incorporating the second and third sugar moiety into the trisaccharide chains at the C-7 or C-10 position
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