题目:Bifunctional Ligand Enables Efficient Gold-Catalyzed Hydroalkenylation of Propargylic Alcohol

作者: Shengrong Liao, Alessio Porta, Xinpeng Cheng, XuMa, Giuseppe Zanoni,* and Liming Zhang*

刊物: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

年卷期页:2018, 57, 8250-8254

摘要：Using the previously designed biphenyl-2-ylphosphine ligand, featuring a remote tertiary amino group, the first gold-catalyzed intermolecular hydroalkenylation of alkynes has been developed. Synthetically valuable conjugated dienyl alcohols are formed in moderate to good yields. A range of alkenyltrifluoroborates are allowed as the alkenyl donor, and no erosion of alkene geometry and/or the propargylic configuration are detected. DFT calculations confirm the critical role of the remote basic group in the ligand as a general-base catalyst for promoting this novel gold catalysis with good efficiency.