题目: Genome mining of Streptomyces atratus SCSIO ZH16: discovery of atratumycin and identification of its biosynthetic gene cluster

作者: Changli Sun, Zhijie Yang, Chunyan Zhang, Zhiyong Liu, Jianqiao He, Qing Liu, Tianyu Zhang, Jianhua Ju, Junying Ma

刊物: Organic Letters

年卷期页: 2019,21,1453-1457

摘要：Genome mining of the deep sea-derived Streptomyces atratus SCSIO ZH16 enabled the activation of a cyclodepsipeptide gene cluster and isolation of its cinnamic acid-bearing product, atratumycin (1). Atratumycin's structure was elucidated on the basis of extensive spectroscopic experiments, X-ray data, and Marfey's method; a plausible biosynthesis and tailoring modification of 1 are also proposed and investigated. Additionally, atratumycin is active against Mycobacteria tuberculosis H37Ra and H37Rv with MICs of 3.8 and 14.6 μM, respectively.