题目: Iakyricidins A‒D, antiproliferative piericidin analogs bearing carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104

作者: Cui Guo, Pei Wang, Xiuping Lin, Limbadri Salendra, Fandong Kong, Shengrong Liao,  Bin Yang, Xuefeng Zhou, Junfeng Wang and Yonghong Liu

刊物: Organic Chemistry Frontiers

年卷期页: 2019,6,3053-3059

摘要：Iakyricidins A-D (1-4), a carbonyl-containing piericidin derivative and three novel piericidin analogues bearing cyclic skeletons, were isolated from the mangrove sediment derived strain Streptomyces iakyrus SCSIO NS104. These structures were established by spectroscopic techniques, Mosher's method, and ECD calculations. Compounds 2-4 represent a novel skeleton of piericidins with branched chain C-C cyclization, and their biosynthetic pathways are proposed. Compound 1, the first natural carbonyl-containing piericidin derivate, exhibited potent antiproliferative activity against ACHN with an IC₅₀ value of 20 nM.