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鞠建华研究团队在《Organic Letters》发表论文

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时间:2020-04-20  作者:LMB  来源:文本大小:【 |  | 】  【打印

题目: On-PKS Baeyer–Villiger-type O-atom insertion catalyzed by luciferase-like monooxygenase OvmO during olimycin biosynthesis

作者: Zhang Chunyan, Zhang Huaran, Ju Jianhua

刊物: Organic Letters

年卷期页: 2020, 22: 1780-1784

摘要A silent ansamycin biosynthetic gene cluster (ovm) was activated in Streptomyces olivaceus SCSIO T05 following mutagenesis and media optimization. A new shunt product, olimycin C (1a) was produced by the ovmO-inactivated mutant strain, along with a minor product, olimycin D (1b). The production of these linear olimycin counterparts suggest that luciferase-like monooxygenase (LLM) OvmO catalyzes an on-PKS Baeyer-Villiger-type oxidation during assembly of the olimycin A (2) linear polyketide backbone.

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