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鞠建华研究团队在《ACS Catalysis》发表论文

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时间:2020-08-12  作者:LMB  来源:文本大小:【 |  | 】  【打印

题目: A luciferase-like monooxygenase and flavin reductase pair AbmE2/AbmZ catalyzes Baeyer–Villiger oxidation in neoabyssomicin biosynthesis

作者: Ji Xiaoqi, Tu Jiajia., Song Yongxiang, Zhang Chunyan, Wang Liyan,  Li Qinglian , Ju Jianhua

刊物: ACS Catalysis

年卷期页: 2020, 10: 2591-2595

摘要Baeyer–Villiger monooxygenases (BVMOs) play important roles in the biosynthesis of natural products. We describe here in vivo gene inactivation/complementation studies as well as in vitro enzyme assays that reveal the bacterial luciferase-like monooxgenase (LLM) AbmE2 and its flavin reductase partner AbmZ as a type II BVMO pair that catalyzes BV oxidation during neoabyssomicin assembly in Streptomyces koyangensis SCSIO 5802. This study provides direct biochemical evidence of an LLM that catalyzes BV oxidation.

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