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张长生研究团队在《Organic Letters》发表论文

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时间:2020-07-08  作者:LMB  来源:文本大小:【 |  | 】  【打印

题目: Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase

作者: Bin Tan,  Siqiang Chen,  Qingbo Zhang,  Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang, and Changsheng Zhang

刊物: Organic Letters

年卷期页: 2020, 22(3): 1062-1066

摘要The heterologous expression of the lobophorin biosynthetic gene cluster from marine-derived Streptomyces pactum SCSIO 02999 has led to the discovery of new analogues that carry d-kijanose (or its variants with a 3-amino or hydroxyl group) at C-9. The identification of intermediates resulting from the inactivation of lobG1 (encoding C-17 kijanosyltransferase) and lobG3 (encoding C-9 digitoxosyltransferase) demonstrates the substrate flexibility of LobG3 to also accept d-kijanose and its variants. Notably, two lobophorins with d-kijanose at C-9 show improved bioactivities.

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