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张长生研究团队在《Organic Letters》发表论文

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时间:2021-07-02  作者:LMB  来源:文本大小:【 |  | 】  【打印

题目: Dassonmycins A and B, Polycyclic Thioalkaloids from a Marine Sponge-Derived Nocardiopsis dassonvillei SCSIO 40065

作者: Xinya Zhang, Siqiang Chen, Liping Zhang, Qingbo Zhang, Wenjun Zhang, Yuchan Chen, Weimin Zhang, Haibo Zhang, and Changsheng Zhang

刊物Organic Letters

年卷期页: 2021, 23(8): 2858-2862

摘要Two polycyclic thioalkaloides dassonmycins A (1) and B (2) were isolated from Nocardiopsis dassonvillei SCSIO 40065 associated with marine sponge Petrosia sp. Structures of 1 and 2 were elucidated by comprehensive spectroscopic analysis and confirmed by single-crystal X-ray diffraction experiments, to have a 6/6/6/6-fused tetracyclic ring featuring a naphthoquinone[2,3-e]piperazine[1,2-c]thiomorpholine scaffold. Compound 2 formed a caged core through an additional ether bridge. Both compounds exhibited moderate antibacterial and cytotoxic activities.

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