张扬博士  研究员       海洋动物遗传学与分子生物学学科组学科组 E-mail：yzhang@scsio.ac.cn

职务描述

1. 中国科学院南海海洋研究所 硕士导师

研究领域

1. 贝类天然免疫

2.贝类基因组学

工作经历

2009.07-2011.10   中国科学院南海海洋研究所/助理研究员

2011.11-2016.11   中国科学院南海海洋研究所/副研究员

2016.12-至今     中国科学院南海海洋研究所/研究员

教育背景

1999.09-2003.06  河南师范大学/生物科学专业/学士

2003.09-2009.06  中山大学/生理学专业/硕博连读

2015.03-2016.03  University of California, Riverside/访问学者

获奖及荣誉

2017 中科院“南海新星”

2016 广东特支计划“科技创新青年拔尖人才”

2015 广东省自然科学基金“杰出青年”

2013中科院“青年创新促进会”

2012广州市“珠江科技新星”

学术任职

受邀担任J Immunol Res的Lead Guest Editor

代表性成果

论文发表：（第一或通讯作者）

    1. Zhang Y, Zhao B, Roy S, Saha TT, Kokoza VA, Li M, Raikhel AS. microRNA-309 targets the Homeobox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 2016;113(33):E4828-36.

    2. Li J, Zhang Y, Liu Y, Zhang Y*, Xiang Z, Qu F, Yu Z*. A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis. Dev Comp Immunol. 2016;57:1-9.

    3. Zhang Y, Sun J, Mu H, Li J, Zhang Y, Xu F, Xiang Z, Qian PY, Qiu JW*, Yu Z*. Proteomic basis of stress responses in the gills of the pacific oyster Crassostrea gigas. J Proteome Res. 2015;14(1):304-17.

    4. Xu F, Zhang Y*, Li J, Zhang Y, Xiang Z, Yu Z*. Expression and function analysis of two naturally truncated MyD88 variants in the Pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 2015;45(2):510-6.

    5. Tong Y, Zhang Y*, Huang J, Xiao S, Zhang Y, Li J, Chen J, Yu Z*. Transcriptomics Analysis of Crassostrea hongkongensis for the Discovery of Reproduction-Related Genes. PLoS One. 2015;10(8):e0134280.

    6. Xu F, Li J, Zhang Y*, Li X, Zhang Y, Xiang Z, Yu Z*. CgIκB3, the third novel inhibitor of NF-kappa B (IκB) protein, is involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2015;46(2):648-55.

    7. Yu M, Zhang Y, Tang X, Ren J, Zhang Y*. The first mollusk spätzle homolog gene in the clam, Paphia undulate. Fish Shellfish Immunol. 2015;47(2):712-6.

    8. Zhang Y, Yu F, Li J, Tong Y, Zhang Y, Yu Z*. The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 2014, 40(2): 466-471.

    9. Li J, Zhang Y(Co-first), Zhang Y, Xiang Z, Tong Y, Qu F, Yu Z*. Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2014. 40(2): 455-465.

    10. Zhang Y, Zhang Y(Co-first), Wang Z, Yan X, Yu Z*. Phenotypic trait analysis of diploid and triploid hybrids from female Crassostrea hongkongensis × male C. gigas. Aquaculture. 2014. 434: 307–314.

    11. Zhang Y, Li J, Yu F, Tong Y, Zhang Y, Xiang Z, Yu Z*. Identification and functional characterization of SIMPL in Crassostrea gigas reveals its ancient origin and involvement in the regulation of Rel/NF-κB transcription activity. Fish Shellfish Immunol. 2014; 40(1):239-44.

    12. Zhang Y, Zhang S, Lu H, Zhang L, Zhang W*. Genes encoding aromatases in teleosts: Evolution and expression regulation. Gen Comp Endocrinol. 2014. pii: S0016-6480(14)00180-4.

    13. Zhang Y, He X, Yu F, Xiang Z, Li J, Thorpe KL, Yu Z*. Characteristic and functional analysis of toll-like receptors (TLRs) in the lophotrocozoan, Crassostrea gigas, reveals ancient origin of TLR-mediated innate immunity. PLoS One. 2013;8(10):e76464.

    14. Zhang Y, Zhang S, Liu Z, Zhang L*, Zhang W*. Epigenetic modifications during sex change repress gonadotropin stimulation of cyp19a1a in a teleost ricefield eel (Monopterus albus). Endocrinology. 2013;154(8):2881-90.

    15. Zhang Y, Li J, Yu F, He X, Yu Z*. Allograft inflammatory factor-1 stimulates hemocyte immune activation by enhancing phagocytosis and expression of inflammatory cytokines in Crassostrea gigas. Fish Shellfish Immunol. 2013;34(5):1071-7.

    16. Zhang Y, Yu Z*. The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas. Fish Shellfish Immunol. 2013 ;34(5):1352-5.

    17. Zhang Y, Zhang S, Zhou W, Ye X, Ge W, Cheng CH, Lin H, Zhang W*, Zhang L*. Androgen rather than estrogen up-regulates brain-type cytochrome P450 aromatase (cyp19a1b) gene via tissue-specific promoters in the hermaphrodite teleost ricefield eel Monopterus albus. Mol Cell Endocrinol. 2012;350(1):125-35.

    18. Zhang Y, Fu D, Yu F, Liu Q, Yu Z*. Two catalase homologs are involved in host protection against bacterial infection and oxidative stress in Crassostrea hongkongensis. Fish Shellfish Immunol. 2011;31(6):894-903.

    19. Zhang Y, He X, Yu Z*. Two homologues of inhibitor of NF-kappa B (IκB) are involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2011;30(6):1354-61.

    20. Zhang Y, He X, Li X, Fu D, Chen J, Yu Z*. The second bactericidal permeability increasing protein (BPI) and its revelation of the gene duplication in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2011;30(3):954-63.

    21. Zhang Y, Zhang W, Yang H, Zhou W, Hu C, Zhang L*. Two cytochrome P450 aromatase genes in the hermaphrodite ricefield eel Monopterus albus: mRNA expression during ovarian development and sex change. J Endocrinol. 2008;199(2):317-3

授权专利：（第一发明人）

    1. 一种新型特异结合LPS的贝类模式识别受体LRRP，专利号：ZL201410075253.5；

    2. 一种新型贝类促进血淋巴细胞吞噬作用的调理素DCP，专利号：ZL201410074589.X。

培养研究生情况

    协助课题组长培养博士2名，硕士5名。