本学科组主要从事微生物功能基因组学研究。研究内容包括两个方面：不同微生物类群特有的基因组特征序列的进化分析；不同微生物类群的特有蛋白在细胞中的功能研究。针对特有蛋白的功能研究，目前正在开展的课题包括：1. 重要微生物资源类群-放线菌（Actinobacteria）特有蛋白在蛋白酶体组装中的作用机制；2. 深海环境富集的Epsilon-变形菌（Epsilon-proteobacteria）特有蛋白在趋向运动信号转导中的调控机制。通过对基因组特征序列的进化分析及特有蛋白的功能解析，我们期望能更好的理解细菌基因、基因组的进化以及特征序列在适应环境变化中发挥的作用。

研究经历

2010年2月 – 2014年8月 耶鲁大学病原微生物系 博士后

课题：功能基因组学方法研究空肠弯曲杆菌（Campylobacter jejuni）在宿主内环境的代谢适应

导师：Jorge E. Galan（病原微生物系主任，美国科学院院士）

2004年1月 – 2009年12月 加拿大麦克马斯特大学生物化学与生物医学系 博士

课题：放线菌与古生菌的比较基因组学与功能基因组学

导师：Radhey S. Gupta

教育背景

2004.1- 2009.12  加拿大麦克马斯特大学 生物化学与生物医学系 博士

1999.9- 2003.7   山东大学生命科学院    生物科学             本科

论文发表情况 

2014：

1.Gao B, Lara-Tejero M, Lefebre M, Goodman AL, Galán JE. Novel components of the flagellar system in epsilon proteobacteria. mBio. 2014 Jun 24;5(3):e01349-14.

 2.Dragoi AM, Swiss R, Gao B, Agaisse H. A functional screen for regulators of E-cadherin expression reveals novel strategies for enforcing an epithelial phenotype in mesenchymal cells. Cancer Research. accepted 2014.

2013:

1.Hannemann S, Gao B, Galán JE. Salmonella modulation of host cell gene expression promotes its intracellular growth. PLoS Pathogens. 2013, 9(10): e1003668.

2012：

1. Gao B & Gupta RS. Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria. Microbiol Mol Biol Rev. 2012, 76:66-112. 、
2. Gao B, Gupta RS. Microbial systematics in the post-genomics era. Antonie Van Leeuwenhoek. 2012, 101(1):45-54.

3. Hofreuter D, Mohr J, Wensel O, Rademacher S, Schreiber K, Schomburg D, Gao B, Galán JE. Contribution of amino acid catabolism to the tissue specific persistence of Campylobacter jejuni in a murine colonization model. PLoS One. 2012, 7(11):e50699.  

4. Liu X，Gao B, Novik V, Galán JE. Quantitative proteomics of intracellular Campylobacter jejuni reveals metabolic reprogramming. PLoS Pathogens. 2012, 8:e1002562. 

2010:

1. Gupta RS & Gao B. Recent advances in understanding microbial systematics. In Microbial Population Genetics. JP Xu, eds. Caister Academic Press, Norfolk, UK. 2010.

2009:

1. Gao B, Sugiman S, Junop MS, Gupta RS. Structural and phylogenetic analysis of a conserved Actinobacteria-Specific Protein (ASP1; SCO1997) from Streptomyces coelicolor. BMC Struct Biol. 2009, 9: 40.

2. Gao B, Mohan R, Gupta RS. Phylogenomics and protein signatures elucidating the evolutionary relationships among the Gammaproteobacteria. Int J Syst Evol Microbiol. 2009, 59: 234-47.

3. Ventura M, Turroni F, Zomer A, Foroni E, Giubellini V, Bottacini F, Canchaya C, Claesson MJ, He F, Mantzourani M, Mulas L, Ferrarini A, Gao B, Delledonne M, Henrissat B, Coutinho P, Oggioni M, Gupta RS, Zhang Z, Beighton D, Fitzgerald GF, O'Toole PW, van Sinderen D. The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity. PLoS Genet. 2009, 12:e1000785.

4. Gupta RS & Gao B. Phylogenomic analyses of clostridia and identification of novel protein signatures that are specific to the genus Clostridium sensu stricto (cluster I). Int J Syst Evol Microbiol. 2009, 59: 285-94.

2007:

1. Gao B & Gupta RS. Phylogenomic analysis of proteins that are distinctive of Archaea and its main subgroups and the origin of methanogenesis. BMC Genomics. 2007, 8: 86.

2006:

1. Gao B, Paramanathan R, Gupta RS. Signature proteins that are distinctive characteristics of Actinobacteria and their subgroups. Antonie Van Leeuwenhoek. 2006, 90: 69-91.

2005:

1. Gao B & Gupta RS. Conserved indels in protein sequences that are characteristic of the phylum Actinobacteria. Int J Syst Evol Microbiol. 2005, 55: 2401-2412.

2003：

1. Nguimbi E, Li YZ, Gao BL, Li ZF, Wang B, Wu ZH, Yan BX, Qu YB, Gao PJ. 16S-23S ribosomal DNA intergenic spacer regions in cellulolytic myxobacteria and differentiation of closely related strains. Syst Appl Microbiol. 2003, 26:262-268.

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