王晓雪博士  研究员 海洋微生物被膜学科组组长 E-mail: xxwang@scsio.ac.cn

职务描述

1. 国家杰出青年科学基金获得者

2. 中组部“青年千人计划”

2. 中国科学院南海海洋研究所研究员，博士生导师，国科大岗位教授，中国科学院特聘研究员骨干人才

研究兴趣与领域

主要从事微生物生理代谢与环境适应机制的研究。本学科组以海洋微生物和模式微生物为研究对象，关注毒素-抗毒素系统及原噬菌体等水平基因转移元件在环境适应性中的功能和调控，并系统阐释这些水平基因转移元件在环境胁迫条件下的调控通路。有望从细菌的自身代谢调控中找到新的关键调控因子作为靶点，为抗药性细菌的抑制提供有效途径。

工作经历

2011.12 至今：中国科学院南海海洋研究所，广东省海洋药物重点实验室，中国科学院热带海洋生物资源与生态重点实验室，研究员，博士生导师；

2008.03 - 2011.11：美国Texas A&M University，生物被膜实验室，博士后；

2007.01 - 2008.01：美国Rutgers University，海洋环境与海洋生物学院，博士后；

2002.05 - 2006.12：美国Texas A&M University，海洋生物遗传实验室，研究助理；

教育背景

2002.05 - 2006.12：美国Texas A&M University，遗传学专业，硕博连读，获博士学位。

1996.09 - 2000.07：中国海洋大学，食品科学专业，获学士学位。

获奖及荣誉

2016-2020    "国家杰出青年科学基金"获得者

2012-2016     "青年千人计划"入选者 

2005-2006    Tom Slick Graduate Research Fellowship, Texas A&M University, USA 

  1.Wang P, Zeng Z, Wang W, Wen Z, Li J,  Wang X*.  (2017) Dissemination and Loss of a Biofilm-related Genomic Island in Marine Pseudoalteromonas Mediated by Integrative and Conjugative Elements. Environmental Microbiology 19(11), 4620–4637

  2.Guo Y, Liu X, Li B, Yao J, Wood TK, Wang X*. (2017) Tail-Anchored Inner Membrane Protein ElaB Increases Resistance to Stress While Reducing Persistence in Escherichia coli. Journal of Bacteriology 199(9):e00057-17

  3.Zeng Z^#, Cai X^#, Wang P, Guo Y, Liu X, Li B, Wang X*. (2017) Biofilm Formation and Heat Stress Induce Pyomelanin Production in Deep-Sea Pseudoalteromonas sp. SM9913. Frontiers in Microbiology 8:(1822)

  4.Zeng Z^#, Guo X^#, Cai X, Wang P, Li B, Yang J*, Wang X*.  (2017) Pyomelanin from Pseudoalteromonas lipolytica reduces biofouling. Microbial Biotechnology 10(6):1718-1731

  5.Sun C, Guo Y, Tang K, Wen Z, Li B, Zeng Z, Wang X*.  (2017) MqsR/MqsA Toxin/Antitoxin System Regulates Persistence and Biofilm Formation in Pseudomonas putida KT2440. Frontiers in Microbiology 8:(840)

  6.Wen Z^#, Wang P^#, Sun C, Guo Y, Wang X*. (2017) Interaction of type IV toxin/antitoxin systems in cryptic prophages of Escherichia Coli K-12. Toxins 9:77

  7.郭云学，李百元，王晓雪*. (2017) 细菌的毒素-抗毒素系统：定时炸弹还是免死金牌. 微生物学报 57(11): 1708-1715

2016：

  1. Wang X*, Wood TK*. (2016). Cryptic Prophages as Targets For Drug Development. Drug Resistance Updates. doi:10.1016/j.drup.2016.06.001

  2. Zeng Z, Liu X, Yao J, Guo Y, Li B, Li Y, Jiao N, Wang X*. (2016). Cold adaptation regulated by cryptic prophage excision in Shewanella oneidensis. The ISME Journal doi:10.1038/ismej.2016.85.

  3. Guo Y*, Yao J, Sun C, Wen Z, Wang X*. (2016)Characterization of the Deep-Sea Streptomyces sp. SCSIO 02999 Derived VapC/VapB Toxin-Antitoxin System in Escherichia coli. Toxins 8, 195.

  4. Li B, Wang P, Zeng Z, Cai X, Wang G, Wang X*. (2016). Complete genome sequence of Pseudoalteromonas rubra SCSIO 6842, harboring a putative conjugative plasmid pMBL6842. Journal of biotechnology 224, 66-67.

  5. Wang P, Wen Z, Li B, Zeng Z, Wang X*. (2016). Complete genome sequence of Vibrio alginolyticus ATCC33787^T isolated from seawater with three native megaplasmids. Marine Genomics. 10.1016/j.margen.2016.05.003

2015：

  1. Zeng Z, Guo X P, Li B, Wang P, Cai X, Tian X, Zhang S, Yang J, Wang X*. (2015). Characterization of self-generated variants in Pseudoalteromonas lipolytica biofilm with increased antifouling activities. Applied microbiology and biotechnology, 99(23): 10127-10139.

  2. Liu X^#, Li Y^#, Guo Y, Zeng Z, Li B, Wood TK, Cai X, Wang X*. (2015). Physiological function of rac prophage during biofilm formation and regulation of rac excision in Escherichia coli K-12. Scientific Reports, 5:16074.

  3. Yao J, Guo Y, Zeng Z, Liu X, Shi F, Wang X*. (2015). Identification and characterization of a HEPN-MNT family type II toxin–antitoxin in Shewanella oneidensis. Microbial Biotechnology 6:961-73.

  4. Wang P, Yu Z, Li B, Cai X, Zeng Z, Chen X, Wang X*. (2015). Development of an efficient conjugation-based genetic manipulation system for Pseudoalteromonas. Microbial Cell Factories 14:11.

  5. Jiao N, Legendre L, Robinson C, Thomas H, Luo Y-W, Dang H, Liu, J, Tang K, Luo T, Li C, Wang X, Zhang C. (2015). Comment on “Dilution limits dissolved organic carbon utilization in the deep ocean”. Science 350: 6267 1483-a. 

2014： 

  1. Guo Y, Quiroga C, Chen Q, McAnulty M, Benedik MJ, Wood TK*,Wang X*. (2014) RalR (a DNase) and RalA (a small RNA) form a type I toxin-antitoxin system in Escherichia coli.  Nucleic Acids Research, 42(10):6448-6462. (*Corresponding author)  

2013: 

  1. Wang X*, Lord DM, Hong SH, Peti W, Benedik MJ, Page R, Wood TK. (2013). Type II toxin-antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS. Environmental Microbiology, 15: 1734-1744. 

2012: 

  1. Wang X*, Lord DM*, Cheng HY*, Osbourne DO, Hong SH, Sanchez-Torres V, Quiroga C, Zheng K, Herrmann T, Peti W, Benedik MJ, Page R, Wood TK. (2012). A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nature Chemical Biology, 8: 855-61. (*equal contribution)  

  2. Hong SH, Hegde M, Kim J, Wang X, Jayaraman A, Wood TK. (2012). Synthetic Quorum Sensing circuit to control consortial biofilm formation and dispersal in a microfluidic device. Nature Communications, 3: 613.

  3. Hong SH, Wang X, O’Connor H, Benedik MJ, Wood TK. (2012).Bacterial persistence increases as environmental fitness decreases. Microbial Biotechnology, 5: 509-22.  

2011： 

  1. Wang X, Kim Y, Hong SH, Ma Q, Brown BL, Pu M, Tarone AM, Benedik MJ, Peti W, Page R, Wood TK. (2011). Antitoxin MqsA helps mediate the bacterial general stress response. Nature Chemical Biology, 7: 359-366.  

  2. Wang X, Wood TK. (2011).  Toxin/antitoxin systems influence biofilm and persister cell formation and the general stress response. Applied and Environmental Microbiology, 77: 5577-5583.  

  3. Wang X, Wood TK. (2011). IS5 inserts upstream of flhDC in a quasi-Lamarckian way. The ISME Journal, 5: 1517–1525.  

2010 ： 

  1. Wang X, Kim Y, Ma Q, Hong SH, Pokusaeva K, Sturnio JM, Wood TK. (2010). Cryptic prophages help bacteria cope with adverse environments. Nature Communications , 1: 147.  

  2. Kim Y, Wang X, Zhang XS, Page R, Peti W, Wood TK. (2010). Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environmental Microbiology, 12: 1105-1121.  

  3. Hong SH, Wang X, Wood TK. (2010). Controlling biofilm formation, prophage excision, and cell death rewiring global regulator H-NS of Escherichia coli. Microbial Biotechnology, 3: 344-356  

2009： 

  1. Wang X, Kim Y, Wood TK. (2009). Control and benefits of CP4-57 prophage excision in Escherichia coli biofilms. The ISME Journal, 3: 1164-1179.  

  2. Kim Y, Wang X, Ma Q, Zhang XS, Wood TK. (2009). Toxin-antitoxin systems in Escherichia coli influence biofilm formations through YjgK (TabA) and fimbriae. Journal of Bacteriology, 191: 1258-1267. 

学科组建设

 1. Wang P, Zeng Z, Wang W, Wen Z, Li J,  Wang X*.  (2017) Dissemination and Loss of a Biofilm-related Genomic Island in Marine Pseudoalteromonas Mediated by Integrative and Conjugative Elements. Environmental Microbiology 19(11), 4620–4637

  2. Guo Y, Liu X, Li B, Yao J, Wood TK, Wang X*. (2017) Tail-Anchored Inner Membrane Protein ElaB Increases Resistance to Stress While Reducing Persistence in Escherichia coli. Journal of Bacteriology 199(9):e00057-17

  3. Zeng Z^#, Cai X^#, Wang P, Guo Y, Liu X, Li B, Wang X*. (2017) Biofilm Formation and Heat Stress Induce Pyomelanin Production in Deep-Sea Pseudoalteromonas sp. SM9913. Frontiers in Microbiology 8:(1822)

  4. Zeng Z^#, Guo X^#, Cai X, Wang P, Li B, Yang J*, Wang X*.  (2017) Pyomelanin from Pseudoalteromonas lipolytica reduces biofouling. Microbial Biotechnology 10(6):1718-1731

  5. Sun C, Guo Y, Tang K, Wen Z, Li B, Zeng Z, Wang X*.  (2017) MqsR/MqsA Toxin/Antitoxin System Regulates Persistence and Biofilm Formation in Pseudomonas putida KT2440. Frontiers in Microbiology 8:(840)

  6. Wen Z^#, Wang P^#, Sun C, Guo Y, Wang X*. (2017) Interaction of type IV toxin/antitoxin systems in cryptic prophages of Escherichia Coli K-12. Toxins 9:77

7.郭云学，李百元，王晓雪*. (2017) 细菌的毒素-抗毒素系统：定时炸弹还是免死金牌. 微生物学报 57(11): 1708-1715