张庆波博士  副研究员

（海洋微生物代谢工程与生物工程学科组  E-mail: zhangqingbo@scsio.ac.cn）

研究领域： 贝类分子免疫及遗传育种学

代表性工作简介

从海洋来源放线菌中分离鉴定化合物130多个，包括新化合物60多个，研究结果发表在Eur J Org Chem，Org Lett和J Antibiot等杂志上；首次报道xiamycin A的生物合成基因簇，并阐明了环化酶XiaI，P450氧化酶XiaM和XiaO，膜蛋白XiaH和黄素氧化酶XiaK在xiamycin A合成中的作用，研究结果发表在J Am Chem Soc，Chem Sci和Org Lett等杂志上；克隆了totopotensamides的生物合成基因簇，分离鉴定具有新颖结构的类似物30多个，研究了该化合物的调控机制，和其中两个P450氧化酶，一个糖基转移酶，一个磺酸基转移酶的功能，该结果发表在Org Let和ACS Chem Biol等期刊上。

工作经历

2008.07-2010.07：广东省微生物研究所，实习研究助理

2017.01-至今：中国科学院南海海洋研究所，副研究员

2013.07-2016.12：中国科学院南海海洋研究所，助理研究员

教育背景

2010.07-2013.07：中国科学院南海海洋研究所海洋生物学，博士

2005.09-2008.07：中山大学药学院，生药学，硕士

2001.09-2005.07：湖南中医药大学药学院，中药学， 学士

2013.05-2013.08：德国马堡大学，短期研修生

2014.09-2014.11：德国马堡大学，短期研修生

获奖及荣誉

1. 中国科学院院长优秀奖（2013）

2. 广州市“珠江科技新星”（2016） 

学术任职

1. 中国药学会海洋药物专业委员会“海洋药物博士论坛”青年委员会委员 

代表性成果

论文发表（第一或通讯作者）

1. Bin Tan^#, Qingbo Zhang^#, Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang*. Deciphering Biosynthetic Enzymes Leading to 4-Chloro-6-Methyl-5,7-Dihydroxyphenylglycine, a Non-Proteinogenic Amino Acid in Totopotensamides, ACS chemical biology. 2020, doi.org/10.1021/acschembio.9b00997

2. Bin Tan,^# Siqiang Chen,^# Qingbo Zhang,* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang, and Changsheng Zhang*. Heterologous Expression Leads to Discovery of Diversi？ed Lobophorin Analogues and a Flexible Glycosyltransferase. Org. Letts.doi.org/10.1021/acs.orglett.9b04597

3. Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang*, Changsheng Zhang*. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research. 2019, DOI: 10.1080/14786419.2019.1616729

4. Qingbo Zhang^#, Huixian Li^#, Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, Shu-Ming Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu* and Changsheng Zhang*. Characterization of the Flavoenzyme XiaK as an N-Hydroxylase and Implications in Indolosesquiterpene Diversification. Chemical Science. 2017, 8(7): 5067-5077.

5. Qingbo Zhang, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Yiguang Zhu,Si Zhang, Weimin Zhang, Changsheng Zhang*. New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039. Journal of Antibiotics. 2013, 66(1): 31-36.

6. Qingbo Zhang, Huixian Li, Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, and Changsheng Zhang*. Carboxyl Formation from Methyl via Triple Hydroxylations by XiaM in Xiamycin A Biosynthesis. Organic Letters. 2012, 14 (24): 6142–6145.

7. Huixian Li^#, Qingbo Zhang^#, Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Xinpeng Tian, Si Zhang, Jianhua Ju, Changsheng Zhang*. Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis. Journal of the American Chemical Society. 2012, 134(21): 8996-9005.

8. Qingbo Zhang, Attila Mandi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtan, Changsheng Zhang*. N-N-Coupled Indolo-sesquiterpene Atropo-Diastereomers from a Marine-Derived Actinomycete. European Journal of Organic Chemistry. 2012, 27, 5256-5262.