王俊锋博士  副研究员

（海洋天然药物化学学科组  E-mail: wangjunfeng@scsio.ac.cn）

研究领域

1.  海洋天然药物化学

2.  海洋微生物代谢产物潜能挖掘

3.  海洋微生物源药物先导化合物发现

代表性工作简介

主要聚焦于从海洋特境微生物资源中发掘药理活性成分和药物先导化合物，近年来分离鉴定海洋微生物来源天然产物500多个，其中新结构化合物285个，其中新颖骨架的6个/类，筛选发现具有抗肿瘤、抗炎、抗病毒、抗菌活性的天然产物120个。近五年主持国家自然科学基金面上和青年项目，广东省科技计划等项目，入选广州市“珠江科技新星人才”计划。研究成果在Organic Letters和Journal of Natural Products等国际知名学术刊物上。

工作经历

2012.06-2016.12：中科院南海海洋研究所，助理研究员

2016.12-至今：中科院南海海洋研究所，副研究员

2019.3-2020.3:加利福尼亚大学洛杉矶分校，访问学者

教育背景

2002.09-2006.06：青岛科技大学化学，学士

2006.09-2009.06：青岛科技大学有机化学，硕士

2009.09-2012.06：中国海洋大学药物化学，博士

获奖及荣誉

1. 广州市“珠江科技新星”（2017） 

代表性成果

论文发表（第一或通讯作者）

31. Guo C, Wang P, Lin X, Salendra L, Kong F, Liao S, Yang B, Zhou X, Wang J*, Liu      Y*. Phloroglucinol heterodimers and bis-indolyl alkaloids from the Sponge-Derived Fungus Aspergillus sp. SCSIO 41018. Org Chem Front, 2019, 6, 3053-3059  (Front Cover Article)

30. Liu N, Peng S, Yang J, Cong Z, Lin X, Liao S, Yang B, Zhou X, Zhou X, Liu Y*, Wang J*. Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301. Fitoterapia, 2019, 135, 27–32.

29. Guo C, Lin X, Liao S, Yang B, Zhou X, Yang X, Tian X, Wang J*, Liu Y.* Two new aromatic polyketides from a deep-sea fungus Penicillium sp. SCSIO 06720. Nat Prod Res, 2019, doi: 10.1080/14786419.2018.1553880.

28. Cong Z, Huang X*, Liu Y, Liu Y, Wang P, Liao S, Yang B, Zhou X, Huang D, Wang J*. Cytotoxic anthracycline and antibacterial tirandamycin analoguesfrom a marine-derived Streptomyces sp. SCSIO 41399. J Antibiot, 2019, 72: 45–49.

27. Pang X, Cai G, Lin X, Salendra L, Zhou X, Yang B, Wang J, Wang J*, Xu S*, Liu Y*. New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO 41015. Mar. Drugs, 2019, 17, 398.

26. Wang J, Qing L, Zhao B, Cai L, Zhong Z, Liu Y, Zhou X*. Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium. Org Biomol Chem, 2019, 17(1): 195–202.

25. Wang J, Cong Z, Huang X, Hou C, Chen W, Tu Z, Huang D, Liu Y*. Soliseptide A, acyclic hexapeptide possessing piperazic acid groups from Streptomyces solisilvae HNM30702. Org Lett, 2018,  20(5): 1371–1374.

24. Pang X, Lin X, Yang J, Zhou X, Yang B, Wang J*, Liu Y*. Spiro-Phthalides and isocoumarins isolated from the marine-sponge-derived fungus Setosphaeria sp. SCSIO41009. J Nat Prod, 2018, 81(8), 1860？1868. (Top 20 Most Read Articles in August, 2018)

23. Pang X, Lin X, Wang P, Zhou X, Yang B, Wang J*, Liu Y*. Perylenequione derivatives with anticancer activities isolated from the marine sponge-derived fungus, Alternaria sp. SCSIO41014. Mar. Drugs, 2018, 16(8), 280.

22. Wang J*, Zhou L, Chen S, Yang B, Liao S, Kong F, Lin X, Wang F, Zhou X, Liu Y*. New chlorinated diphenyl ethers and xanthones from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Fitoterapia, 2018, 125, 49–54.

21. Pang X, Lin X, Wang J*, Liang R, Tian Y, Salendra L, Luo X, Zhou X, Yang B, Tu Z, Liu Y*. Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007. Steroids, 2018, 129, 41–46.

20. Wang J, He W, Kong F, Tian T, Wang P, Zhou X*, Liu Y*. Ochracenes A？I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis. J Nat Prod, 2017, 80(6): 1725–1733. (Highlighted by Natural Products Reports)

19. Wang J, Liang R, Liao S, Yang B, Tu Z, Lin X, Wang B, Liu Y*. Vaccinols J–S, ten new salicyloid derivatives from the marine mangrove-derived endophytic fungus Pestalotiopsis vaccinii. Fitoterapia, 2017, 120: 164–170.

18. He W, Zhou X, Qin X, Mai Y, Lin X, Liao S, Yang B, Zhang T, Tu Z, Wang J*, Liu Y*. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derivedfungus Gliomastix sp. ZSDS1-F7. Nat Prod Res, 2017, 31(5): 604–609.

17. Wang J, Wei X, Qin X, Tian X, Liao L, Li K, Zhou X, Yang X, Wang F, Tu Z, Chen B, Liu Y*. Antiviral Merosesquiterpenoids Produced by the Antarctic Fungus Aspergillus ochraceopetaliformis SCSIO 05702, J Nat Prod, 2016, 79(1): 59–65. (Highlighted by Natural Products Reports)

16. Wang J, He W, Huang X, Tian X, Liao S, Yang B, Wang F, Zhou X, Liu Y*. Antifungal New Oxepine-Containing Alkaloids and Xanthones from the Deep-Sea-Derived Fungus Aspergillus versicolor SCSIO 05879, J Agric Food Chem, 2016, 64(16): 2910–2916.

15. Wang J, Qin X, Chen Z, Ju Z, He W, Tan Y, Zhou X, Tu Z, Lu F*, Liu Y*. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni), Phytochem Lett, 2016, 15: 13–15.

14. Zhao B^#, Peng S^#, He W, Liu Y, Wang J*, Zhou X*. Antitubercular and cytotoxic tigliane-type diterpenoidsfrom Croton tiglium, Bioorg Med Chem Lett, 2016, 26(20): 4996–4999.

13. Xu G^#, Wang Z^#, Zhao B, Liu N, Yang S, Liu Y, Wang J*, Zhou X*. Saniculamins A and B, two new flavonoids from Sanicula lamelligera Hance inhibiting LPS-inducednitric oxide release, Phytochem Lett, 2016, 18: 35–38.

12. Wang J, Wei X, Qin X, Lin X, Zhou X, Liao S, Yang B, Liu J, Tu Z, Liu Y*. Arthpyrones A–C, pyridine alkaloids from a sponge-derivied fungus Arthrinium arundinis ZSDS1-F3. Org Lett, 2015, 17(3): 656–659. (ACS Editors' Choice, Highlighted by Natural Products Reports)

11. Wang J, He W, Qin X, Wei X, Tian X, Liao L, Liao S, Yang B, Tu Z, Chen B, Wang F, Zhou X*, Liu Y*. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp. SCSIO 05705, RSC Adv, 2015, 5(84): 68736–68742.

10. Wang J, Wang Z, Ju Z, Wan J, Liao S, Lin X, Zhang T, Zhou X, Chen H, Tu Z*, Liu Y*. Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinis. Planta Med, 2015, 81(2): 160–166.

9. Wang J, He W, Zhang X, Zhao B, Liu Y, Zhou X*. Dicarabrol, a new dimer icsesquiterpene from Carpesium abrotaoides L. Bioorg Med Chem Lett, 2015, 25(19): 4082–4084.

8. Wang J^#, Yang S^#, Liu Y, Li D, He W, Zhang X, Liu Y*, Zhou X*. Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium. Bioorg Med Chem Lett, 2015, 25(9): 1986–1989.

7. Yang S^#, Liu Y^#, Wang J*, Wang Y, Pan W, Sheng W, Cai R, Zhou X*. Isoquinoline alkaloids from Zanthoxylum simulans and their biological evaluation, J Antibiot, 2015, 68(4): 289–292.

6. Wang J, Wei X, Qin X, Chen H, Lin X, Zhang T, Yang X, Liao S, Yang B, Liu J, Zhou X, Tu Z*, Liu Y*. Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce. Phytochem Lett, 2015, 12: 59–62.

5. Wang J^#, Qin X^#, Xu F, Zhang T, Liao S, Lin X, Yang B, Liu J, Wang L, Tu Z*, Liu Y*. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation. Nat Prod Res, 2015, 29(18): 1761–1765.

4. Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z, Liu Y*. Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel(L.) Druce. Tetrahedron, 2014, 70(51): 9695–9701.

3. Wang J, Deng Y, Yang S, Liu Y, Wang Y, Pan W, Zhou X*. Characterization and biological evaluation of six new dimericlignans with an unusual α,β-unsaturated ketone motif from Zanthoxylum simulans, Bioorg Med Chem Lett, 2014, 24(19): 4667–4671.

2. Wang J, Xu F, Wang Z, Lu X, Wan J, Yang B, Zhou X, Zhang T, Tu Z, Liu Y*. A new naphthalene glycoside from the sponge-derived fungus Arthrinium sp. ZSDS1-F3. Nat Prod Res, 2014, 28(14): 1070–1074.

1. Wang J^#, Lin X^#, Qin C, Liao S, Wan J, Zhang T, Liu J, Fredimoses M, Chen H, Yang B, Zhou X, Yang X, Tu Z*, Liu Y*. Antimicrobial and antiviral sesquiterpenoids from sponge-associated fungus, Aspergillus sydowii ZSDS1-F6. J Antibiot, 2014, 67(8): 581–583.

授权发明专利

1. 王俊锋, 刘永宏, 周雪峰, 廖升荣, 杨献文, 杨斌, 林秀萍, 刘娟。吡啶酮生物碱类化合物及其制备方法和在制备抗肿瘤药物中的应用。专利号:：ZL201410021280.4.

2. 王俊锋, 刘永宏, 周雪峰, 廖升荣, 杨献文, 杨斌, 林秀萍, 刘娟。生物碱类化合物在制抗肠道病毒及乙酰胆碱酯酶抑制剂药物中的应用。专利号：ZL201410021315.4.

3. 王俊锋, 贺卫军, 田新朋, 刘永宏。一种α-吡喃酮混源萜及其制备方法和应用。专利号：ZL201510244085.2.

4. 王俊锋, 贺卫军, 黄小龙, 田新朋, 刘永宏。抗生素Versicoloids A 和B及其制备方法和在制备抗植物病原菌药物中的应用。专利号：ZL201610046509.9.

5. 王俊锋，贺卫军，黄小龙，田新朋，刘永宏。海洋曲霉SCSIO 05879制备Versicoloids A和B及在抗胶孢炭疽菌药物中的应用. 专利号：ZL 201710505896.2.

6. 王俊锋，孔凡栋，田新朋，周小江，刘永宏。一类新颖结构倍半萜化合物及其在制备抗炎药物中的应用。专利号:ZL201610578329.5