李军博士  项目副研究员

（海洋动物遗传学与分子生物学学科组   E-mail：jun.li@scsio.ac.cn）

研究领域

 贝类分子免疫及遗传育种学

代表性工作简介

1）香港牡蛎温度胁迫适应机制的分子基础,针对牡蛎具有异常出色对抗高温和急性热激的能力。首次采用数字基因表达谱对香港牡蛎温度胁迫机制进行解析，揭示了牡蛎温度适应的分子基础，为牡蛎耐高温新品系的培育提供应用指导。

2）砗磲性别决定机制及性腺人工促熟,全面系统的阐明了鳞砗磲性腺发育规律及其繁殖周期，构建了鳞砗磲性腺发育周期文库，初步解析了鳞砗磲的雌雄性腺的同步化发育机理，为砗磲的性别决定、分化和性腺发育的遗传机理以及良种选育和繁殖调控提供理论基础。依据鳞砗磲性腺发育机理，开发了一套砗磲陆基暂养促熟方法，解决了配子发生同步性差的难题，为砗磲人工繁育提供亲本来源及应用基础。

工作经历

2020.1-至今：中国科学院南海海洋研究所，项目聘用副研究员

2014.07-2019.12：中国科学院南海海洋研究所，助理研究员

2020.01-至今：中国科学院南海海洋研究所，项目副研究员

教育背景

2004.09-2008.06：西南民族大学/生物技术，学士

2008.09-2014.06：中国科学院南海海洋研究所海洋生物学，博士

获奖及荣誉

1. 2017年 广东省海洋科技与渔业十大进展（砗磲人工繁育技术）

2. 2018年 广州市珠江科技新星

代表性成果

论文发表（第一或通讯作者）

1. Yuehuan Zhang, Yanping Qin, Haitao Ma, Zihua Zhou, Shu Xiao, Ying Pan, Jun Li*., Ziniu Yu*. Gametogenesis from the early history life stages of the Kumamoto oyster Crassostrea sikamea and their breeding potential evaluation. 2019, 10: 524. Frontiers in Physiology

2. Jun Li#, Yuehuan Zhang#, Fan Mao, Yue Lin, Shu Xiao, Zhiming Xiang, Haitao Ma, YangZhang*, ZiniuYu*. The first morphologic and functional characterization of hemocytes in Hong Kong oyster, Crassostrea hongkongensis. Fish & Shellfish Immunology. 2018,81:423-429

3. Li Jun, Zhang Yang, Zhang Yuehuan, Mao Fan, Xiao Shu, Xiang Zhiming, Ma Haitao, Yu Ziniu*. A Lysin motif (LysM)-containing protein from Hong Kong oyster, Crassostrea hongkongensis functions as a pattern recognition protein. Gene. 2018,674:134-142

4. J Li, et al. The first invertebrate NFIL3 transcription factor with role in immune defense identified from, Crassostrea hongkongensis. Developmental and Comparative Immunology. 2017, 76: 1-8

5. J Li, et al. Characterization and Identification of Differentially Expressed Genes Involved in Thermal Adaptation of the Hong Kong Oyster Crassostrea hongkongensis by Digital Gene Expression Profiling. Frontiers in Marine Science. 2017, doi:10.3389/fmars.2017.00112

6. J Li, et al. Co-expression of heat shock protein (HSP) 40 and HSP70 in Pinctada martensii response to thermal, low salinity and bacterial challenges. Fish Shellfish Immunology. 2016, (48), 239-243 (I区TOP, IF=3.148)

7. J Li, et al. A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis. Developmental and Comparative Immunology. 2016, (57), 1-9

8. J Li, et al. Cloning and characterization of three suppressors of cytokine signaling (SOCS) genes from the Pacific oyster, Crassostrea gigas Fish Shellfish Immunology. 2015, 44(2): 525-532 (I区TOP, IF=3.148)

9. Y Zhang , J Li(共同第1作者), et al. Performance evaluation of reciprocal hybrids derived from the two brackish oysters, C. hongkongensis and C. sikamea in southern China. Aquaculture. 2017, 473: 310-316 (II区TOP, IF=2.570)

10. J Li, et al. Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunology. 2014, 40: 455-465. (I区TOP, IF=3.148)

11. Y Zhang, J Li(共同第1作者), et al. A comparative study of the survival, growth and gonad development of the diploid and triploid Hong Kong oyster, Crassostrea hongkongensis (Lam & Morton 2003). Aquaculture Research. 2016, DOI: 10.1111/are.13081.

12. J Li, et al. High mobility group box 1 can enhance NF-kB activation and act as a pro-inflammatory molecule in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunology. 2013, 35(1):63-70 (I区TOP, IF=3.148

13. J Li, et al. Expression of allograft inflammatory factor-1 (AIF-1) in response to bacterial challenge and tissue injury in the pearl oyster, Pinctada martensii. Fish Shellfish Immunology. 2013, 34: 365-371 (I区TOP, IF=3.148

14. M Yu, J Chen, Y Bao, J Li*.Genomic analysis of NF-κB signaling pathway reveals its complexity in Crassostrea gigas Fish Shellfish Immunology.2018, 72: 510-518.

授权专利（第一发明人）

1. 李军、张扬、喻子牛、张跃环 一种淋巴因子TAL及其编码基因和应用 ZL201610024181.0

2. 李军、张跃环、肖述、向志明、喻子牛 一种砗磲陆基暂养促熟方法 ZL201610454164.0

3. 李军、张跃环、喻子牛 一种利用牡蛎体腔液中淋巴细胞检测牡蛎倍性的方法 ZL201510194867.X

4. 李军、喻子牛、张跃环、张扬 一种以右壳颜色为标记的熊本牡蛎制种方法 ZL201510671206.1

5. 李军，张扬，张跃环，喻子牛，一种利用牡蛎体腔液中淋巴细胞检测牡蛎倍性的方法，ZL201510194867.X

6. 李军，喻子牛，张跃环，张扬，刘映，一种以右壳颜色为标记的熊本牡蛎制种方法，ZL2015106712061

7. 李军、张跃环、肖述、向志明、喻子牛，一种砗磲陆基暂养促熟方法，ZL2016104541640

8. 李军; 张扬; 喻子牛; 刘映; 张跃环，一种淋巴因子TAL及其编码基因和应用，ZL2016100241810