张扬博士  研究员

（海洋动物遗传学与分子生物学学科组学科组  yzhang@scsio.ac.cn）

研究领域

1. 贝类天然免疫

2. 贝类基因组学

代表性工作简介

主要学术贡献1）勾勒了牡蛎胁迫适应性形成的分子基础，为深入了解贝类抗逆机制提供了基础和框架；2）解析了牡蛎体液免疫的分子基础：首次利用shotgun蛋白组技术和功能性实验对牡蛎血浆蛋白进行了大规模鉴定和功能解析，为揭示贝类体液免疫的分子机制提供了基础；3）鉴定了牡蛎模式识别受体的演化特征和功能：首次在贝类分析了模式识别受体TLR的结构和功能，结构显示牡蛎TLR家族成员分化程度较低，阻断TLR信号可以有效的抑制感染依赖的血淋巴激活，揭示了TLR介导的天然免疫在低等原口动物中已经形成。

工作经历

2009.07-2011.10：中国科学院南海海洋研究所，助理研究员

2011.11-2016.11：中国科学院南海海洋研究所，副研究员

2016.12-至今：中国科学院南海海洋研究所，研究员

教育背景

1999.09-2003.06：河南师范大学/生物科学专业，学士

2003.09-2009.06：中山大学/生理学专业，硕博连读

2015.03-2016.03：University of California，Riverside，访问学者

获奖及荣誉

1. 广州市“珠江科技新星”（2012）

2. 中科院青年创新促进会会员（2013）

3. 广东省自然科学基金“杰出青年”（2015）

4. 广东特支计划“科技创新青年拔尖人才”（2016） 

学术任职

1. Journal of Immunology Research特约编辑（Editorial Board）（2015-至今）

代表性成果

论文发表（第一或通讯作者）

27. Gametogenesis from the early history life stages of the Kumamoto oyster Crassostrea sikamea and their breeding potential evaluation，Yuehuan Zhang, Yanping Qin, Haitao Ma, Zihua Zhou, Shu Xiao, Ying Pan, Jun Li*., Ziniu Yu*，Frontiers in Physiology，2019, 10: 524

26. Jun Li#, Yuehuan Zhang#, Fan Mao, Yue Lin, Shu Xiao, Zhiming Xiang, Haitao Ma, YangZhang*, ZiniuYu*. The first morphologic and functional characterization of hemocytes in Hong Kong oyster, Crassostrea hongkongensis. Fish & Shellfish Immunology. 2018,81:423-429

25. Mao, F., Lin, Y., He, Z., Li, J., Xiang, Z., Zhang, Y*., Yu, Z*. Dual roles of cystatin A in the immune defense of the pacific oyster, Crassostrea gigas. Fish & Shellfish Immunology. 2018,75:190-197

24. Xiao, S., Wong, N. K., Li, J., Lin, Y., Zhang, Y., Ma, H., Zhang Y*., Yu, Z*. Analysis of in situ transcriptomes reveals divergent adaptive response to hyper-and hypo-salinity in the Hong Kong Oyster, Crassostrea hongkongensis. Frontiers in physiology. 2018,9:1491

23. Zhou, Y., Mao, F., He, Z., Li, J., Zhang, Y., Xiang, Z., Zhang Y*., Yu, Z*. The molecular mechanism underlying pro-apoptotic role of hemocytes specific transcriptional factor Lhx9 in Crassostrea hongkongensis. Frontiers in physiology. 2018,9:612

22. Mao, F., Lin, Y., Zhou, Y., He, Z., Li, J., Zhang, Y*., Yu, Z*. Structural and functional analysis of interferon regulatory factors (IRFs) reveals a novel regulatory model in an invertebrate, Crassostrea gigas. Developmental and  Comparative Immunology. 2018,89:14-22

21. Zhang Y, Zhao B, Roy S, Saha TT, Kokoza VA, Li M, Raikhel AS. microRNA-309 targets the Homeobox gene SIX4 and controls ovarian development in the mosquito Aedes aegypti. Proc Natl Acad Sci U S A. 2016;113(33):E4828-36.

20. Li J, Zhang Y, Liu Y, Zhang Y*, Xiang Z, Qu F, Yu Z*. A thymosin beta-4 is involved in production of hemocytes and immune defense of Hong Kong oyster, Crassostrea hongkongensis. Dev Comp Immunol. 2016;57:1-9.

19. Zhang Y, Sun J, Mu H, Li J, Zhang Y, Xu F, Xiang Z, Qian PY, Qiu JW*, Yu Z*. Proteomic basis of stress responses in the gills of the pacific oyster Crassostrea gigas. J Proteome Res. 2015;14(1):304-17.

18. Xu F, Zhang Y*, Li J, Zhang Y, Xiang Z, Yu Z*. Expression and function analysis of two naturally truncated MyD88 variants in the Pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 2015;45(2):510-6.

17. Tong Y, Zhang Y*, Huang J, Xiao S, Zhang Y, Li J, Chen J, Yu Z*. Transcriptomics Analysis of Crassostrea hongkongensis for the Discovery of Reproduction-Related Genes. PLoS One. 2015;10(8):e0134280.

16. Xu F, Li J, Zhang Y*, Li X, Zhang Y, Xiang Z, Yu Z*. CgIκB3, the third novel inhibitor of NF-kappa B (IκB) protein, is involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2015;46(2):648-55.

15. Yu M, Zhang Y, Tang X, Ren J, Zhang Y*. The first mollusk sp？tzle homolog gene in the clam, Paphia undulate. Fish Shellfish Immunol. 2015;47(2):712-6.

14. Zhang Y, Yu F, Li J, Tong Y, Zhang Y, Yu Z*. The first invertebrate RIG-I-like receptor (RLR) homolog gene in the pacific oyster Crassostrea gigas. Fish Shellfish Immunol. 2014, 40(2): 466-471.

13. Li J, Zhang Y(Co-first), Zhang Y, Xiang Z, Tong Y, Qu F, Yu Z*. Genomic characterization and expression analysis of five novel IL-17 genes in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2014. 40(2): 455-465.

12. Zhang Y, Zhang Y(Co-first), Wang Z, Yan X, Yu Z*. Phenotypic trait analysis of diploid and triploid hybrids from female Crassostrea hongkongensis × male C. gigas. Aquaculture. 2014. 434: 307–314.

11. Zhang Y, Li J, Yu F, Tong Y, Zhang Y, Xiang Z, Yu Z*. Identification and functional characterization of SIMPL in Crassostrea gigas reveals its ancient origin and involvement in the regulation of Rel/NF-κB transcription activity. Fish Shellfish Immunol. 2014; 40(1):239-44.

10. Zhang Y, Zhang S, Lu H, Zhang L, Zhang W*. Genes encoding aromatases in teleosts: Evolution and expression regulation. Gen Comp Endocrinol. 2014. pii: S0016-6480(14)00180-4.

9.  Zhang Y, He X, Yu F, Xiang Z, Li J, Thorpe KL, Yu Z*. Characteristic and functional analysis of toll-like receptors (TLRs) in the lophotrocozoan, Crassostrea gigas, reveals ancient origin of TLR-mediated innate immunity. PLoS One. 2013;8(10):e76464.

8.  Zhang Y, Zhang S, Liu Z, Zhang L*, Zhang W*. Epigenetic modifications during sex change repress gonadotropin stimulation of cyp19a1a in a teleost ricefield eel (Monopterus albus). Endocrinology. 2013;154(8):2881-90.

7.  Zhang Y, Li J, Yu F, He X, Yu Z*. Allograft inflammatory factor-1 stimulates hemocyte immune activation by enhancing phagocytosis and expression of inflammatory cytokines in Crassostrea gigas. Fish Shellfish Immunol. 2013;34(5):1071-7.

6.  Zhang Y, Yu Z*. The first evidence of positive selection in peptidoglycan recognition protein (PGRP) genes of Crassostrea gigas. Fish Shellfish Immunol. 2013 ;34(5):1352-5.

5.  Zhang Y, Zhang S, Zhou W, Ye X, Ge W, Cheng CH, Lin H, Zhang W*, Zhang L*. Androgen rather than estrogen up-regulates brain-type cytochrome P450 aromatase (cyp19a1b) gene via tissue-specific promoters in the hermaphrodite teleost ricefield eel Monopterus albus. Mol Cell Endocrinol. 2012;350(1):125-35.

4.  Zhang Y, Fu D, Yu F, Liu Q, Yu Z*. Two catalase homologs are involved in host protection against bacterial infection and oxidative stress in Crassostrea hongkongensis. Fish Shellfish Immunol. 2011;31(6):894-903.

3.  Zhang Y, He X, Yu Z*. Two homologues of inhibitor of NF-kappa B (IκB) are involved in the immune defense of the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2011;30(6):1354-61.

2.  Zhang Y, He X, Li X, Fu D, Chen J, Yu Z*. The second bactericidal permeability increasing protein (BPI) and its revelation of the gene duplication in the Pacific oyster, Crassostrea gigas. Fish Shellfish Immunol. 2011;30(3):954-63.

1. Zhang Y, Zhang W, Yang H, Zhou W, Hu C, Zhang L*. Two cytochrome P450 aromatase genes in the hermaphrodite ricefield eel Monopterus albus: mRNA expression during ovarian development and sex change. J Endocrinol. 2008;199(2):317-3

授权专利（第一发明人）

1. 一种新型特异结合LPS的贝类模式识别受体LRRP，专利号：ZL201410075253.5

2. 一种新型贝类促进血淋巴细胞吞噬作用的调理素DCP，专利号：ZL201410074589.X。

培养研究生情况

硕士研究生：何志营（2016级），张翔宇（2017级），刘坤娜（2018级），杨倬（2019级）