周雪峰博士 项目研究员

（海洋天然药物化学学科组  E-mail：xfzhou@scsio.ac.cn）

研究领域  

(1) 海洋微生物活性天然产物的发现

(2) 海洋药物先导化合物的优化和药理机制研究

代表性工作简介

重点研究热带海洋微生物药物先导化合物。主要学术贡献：1)海洋药用微生物资源的挖掘：建立化学排重和活性筛选结合的活性化合物高效挖掘体系，从海洋微生物中筛选发现新结构的活性化合物百余个；2)海洋药物先导物的发现：筛选优化4个药效显著、靶标清晰、具有开发价值的药物先导物；3)海洋候选药物成药性评价：对具有抗肾癌药物开发潜力的粉蝶霉素进行成药性评价。

工作经历

2008.07-2010.12：中国科学院南海海洋研究所，助理研究员

2014.06-2015.06：美国加州大学圣地亚哥分校Scripps海洋研究所公派访问学者

2010.12-2019.12：中国科学院南海海洋研究所，副研究员

2020.01-至今：中国科学院南海海洋研究所，项目研究员

教育背景 

1999.09-2003.06：华中科技大学同济医学院，理学学士

2003.07-2008.06：华中科技大学同济医学院，理学博士 

获奖及荣誉

1. 广东省特支计划“百千万工程青年拔尖人才”（2014）

2. 广州市“珠江科技新星”（2015）

3. 广东省自然科学杰出青年基金（2019） 

学术任职

1. 中国药学会海洋药物专业委员会委员（2019-2024）

2. 中国药学会海洋药物专业委员会青年委员会委员（2018-2022）

3. 《中国医院药学杂志》通讯编委（2017-至今）

4. Chinese Chemical Letters 青年编委（2019-至今）

代表性成果

论文发表（近三年第一或通讯作者）

20.  Zhou Xuefeng^#,*; Liang Zhi^#; Li Kunlong; Fang Wei; Tian Yuanxin; Luo Xiaowei; Chen Yulian; Zhan Zhikun; Zhang Tao; Liao Shengrong; Liu Shuwen; Liu Yonghong; Fenical William; Tang Lan*. Exploring the natural piericidins as anti-renal cell carcinoma agents targeting peroxiredoxin 1. Journal of Medicinal Chemistry, 2019. DOI: 10.1021/acs.jmedchem.9b00598.

19. Li Kunlong, Liang Zhi, Chen Weihao, Luo Xiaowei, Fang Wei, Liao Shengrong, Lin Xiuping, Yang Bin, Wang Junfeng, Tang Lan,* Liu Yonghong,* and Zhou Xuefeng*. Iakyricidins A？D, antiproliferative piericidin analogs bearing carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. The Journal of Organic Chemistry, 2019. DOI: 10.1021/acs.joc.9b01270.

18. Luo Xiaowei; Chen Chunmei; Tao Huaming; Lin Xiuping; Yang Bin; Zhou Xuefeng*; Liu Yonghong*. Structurally diverse diketopiperazine alkaloids from the marine-derived fungus Aspergillus versicolor SCSIO 41016. Organic Chemistry Frontiers, 2019, 6: 736~740.

17. Luo Xiao-Wei; Lin Yun; Lu Yong-Jun; Zhou Xue-feng*; Liu Yong-hong*. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chinese Journal of Natural Medicines, 2019, 17(2): 149~154.

16. Lin Xiuping^#; Li Kunlong^#; Yang Lilin; Peng Xiaoying; Fang Wei; Tian Xinpeng*; Liu Yonghong; Zhou Xuefeng*. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field. Natural Product Research, 2019, 33(4): 494–499.

15. Tan Suiyi^#; Yang Bin^#; Liu Juan; Xun Tianrong; Liu Yonghong; Zhou Xuefeng*. Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent. Natural Product Research, 2019, 33(10): 1467-1471.

14. Wang Jianjiao^#; Chen Feimin^#; Liu Yunhao; Liu Yuxuan; Li Kunlong; Yang Xiliang; Liu Shuwen*; Yang Jie*, Zhou Xuefeng*. Spirostaphylotrichin X from a marine-derived fungus as an anti-influenza agent targeting RNA polymerase PB2. Journal of Natural Products, 2018, 81(12): 2722~2730.

13. Fang Wei; Wang Jianjiao; Wang Junfeng; Shi Liqiao; Li Kunlong; Lin Xiuping; Min Yong; Yang Bin; Tang Lan; Liu Yonghong; Zhou Xuefeng*. Cytotoxic and antibacterial eremophilane sesquiterpenes from the marine-derived fungus Cochliobolus lunatus SCSIO41401. Journal of Natural Products, 2018, 81(6): 1405~1410.

12. Luo Xiaowei; Lin Xiuping; Tao Huaming; Wang Junfeng; Li Jiayi; Yang Bin; Zhou Xuefeng*; Liu Yonghong*. Isochromophilones A-F, cytotoxic chloroazaphilones from the marine mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Journal of Natural Products, 2018, 81(4): 934~941.

11. Tan Yanhui^#; Yang Bin^#; Lin Xiuping; Luo Xiaowei; Pang Xiaoyan; Tang Lan; Liu Yonghong; Li Xiaojuan*; Zhou Xuefeng*. Nitrobenzoyl sesquiterpenoids with cytotoxic activities from a marine-derived Aspergillus ochraceus fungus. Journal of Natural Products, 2018, 81(1): 92~97.

10. Tian Yongqi; Lin Xiuping; Zhou Xuefeng*; Liu Yonghong*. Phenol derivatives from the sponge-derived fungus Didymellaceae sp. SCSIO F46. Frontiers in Chemistry, 2018, 6: 536.

9. Luo Xiaowei^#; Yang Jie^#; Chen Feimin; Lin Xiuping; Chen Chunmei; Zhou Xuefeng*; Liu Shuwen*; Liu Yonghong*. Structurally diverse polyketides from the mangrove-derived fungus Diaporthe sp. SCSIO 41011 with their anti-influenza A virus activities. Frontiers in Chemistry, 2018, 6: 282.

8. Yang Bin; Tao Huaming; Lin Xiuping; Wang Junfeng; Liao Shengrong; Dong Junde; Zhou Xuefeng*; Liu Yonghong*. Prenylated indole alkaloids and chromone derivatives from the fungus Penicillium sp SCSI0041218. Tetrahedron, 2018, 74(1): 77~82.

7. Luo Xiaowei; Zhou Xuefeng*; Liu Yonghong*. Nitrogenous compounds produced by the deep sea derived fungus Leptosphaeria sp SCSIO 41005. Natural Product Communications, 2018, 13(6): 677~678.

6. Lin Xiuping^#; Wu Qinyu^#; Yu Yuying; Liang Zhi; Liu Yonghong; Zhou Lili*; Tang Lan*; Zhou Xuefeng*. Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities. Scientific Reports, 2017, 7: 10757.

5. Luo Xiaowei; Lin Xiuping; Salendra Limbadri; Pang Xiaoyan; Dai Yu; Yang Bin; Liu Juan; Wang Junfeng; Zhou Xuefeng*; Liu Yonghong*. Isobenzofuranones and isochromenones from the deep-sea derived fungus Leptosphaeria sp SCSIO 41005. Marine Drugs, 2017, 15(7): 204.

4. Yang Xiliang*; Peng Qingyun; Liu Qian; Hu Jie; Tang Zhipeng; Cui Lianjie; Lin Zonghao; Xu Bing; Lu Kuojian; Yang Fang; Sheng Zhizheng; Yuan Qiong; Liu Song; Zhang Jiuliang; Zhou Xuefeng*. Antioxidant activity against H2O2-induced cytotoxicity of the ethanol extract and compounds from Pyrola decorate leaves. Pharmaceutical Biology, 2017, 55(1): 1843~1848.

3. Zhou Xuefeng^#; Fang Wei^#; Tan Suiyi^#; Lin Xiuping; Xun Tianrong; Yang Bingjie; Liu Shuwen*; Liu Yonghong*. Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. Bioorganic & Medicinal Chemistry Letters, 2016, 26(2): 361~365.

2. Zhou Xuefeng; Fenical William*. The unique chemistry and biology of the piericidins. Journal of Antibiotics. 2016, 69(8): 582~593.

1. Fang Wei^#; Lin Xiuping^#; Wang Jianjiao; Liu Yonghong; Tao Huaming*; Zhou Xuefeng*. Asperpyrone-type bis-naphtho-pyrones with COX-2-inhibitory activities from marine-derived fungus Aspergillus niger. Molecules, 2016, 21: 941.

申请和授权专利（第一发明人）

1. 周雪峰，等。两个粉蝶霉素葡萄糖苷及其在抗肾癌药物中的应用。申请号：201811340841.1。

2. 周雪峰，等。三个粉蝶霉素类天然产物及其在制备抗肾癌药物中的应用。申请号：201811340842.6。

3. 周雪峰，等。一类硝基苯酯倍半萜类化合物及其在制备抗肾癌药物中的应用。申请号：201710861987.X。

4. 周雪峰，等。一种链霉菌及其代谢产物粉蝶霉素类化合物在抗肾癌中的应用。申请号：201710344174.3。

5. 周雪峰，等。粉蝶霉素类化合物Piericidin A在制备抗肾癌药物中的应用。申请号：201610965145.4

6. 周雪峰，等。倍半萜硝基苯酯类化合物及其制备方法和在制备抗肿瘤药物中的应用。专利号：ZL201310464296.8（授权）

7. 周雪峰，等。一种来源于海绵的甾醇及其制备方法和应用。专利号：ZL200910193049.2（授权）

培养研究生情况

硕士研究生：王健娇（2017级）、彭清云（2018级）、蔡健（2019级）