鞠建华研究员

中国科学院南海海洋研究所 所长助理

中国科学院热带海洋生物资源与生态重点实验室 主任

广东省海洋药物重点实验室 主任

（海洋微生物天然产物及其生物合成学科组责任研究员 jju@scsio.ac.cn）

研究兴趣与领域

以海洋微生物为研究对象，以海洋微生物活性次级代谢产物的生物学功能及其形成机制为拟解决的关键科学问题。主要从特殊海洋环境中（深海沉积物、珊瑚礁生态系统、不同深度的海水层、特色海洋生物等）分离、培养、鉴定海洋放线菌、真菌和细菌；综合运用微生物学、天然产物化学、细菌遗传学、分子生物学、生物信息学、生物化学和药理学等多学科专业技能，从海洋微生物中筛选发现新的生物活性物质，发掘新的生物合成途径、新型酶催化反应机理，利用代谢工程、组合生物合成和合成生物学技术手段构建新结构衍生物，并对具有自主产权、有前景的化合物进行成药性评价和药物开发，具体包括以下内容：

(1) 海洋微生物活性次级代谢产物的发现（Marine Bioactive Natural Products Discovery）。利用化学生态学原理和多种发酵培养技术，从海洋微生物中筛选、分离和鉴定结构新颖、活性显著的生物活性物质。研究海洋微生物产生的活性物质在特定海洋生态系统中的化学防御机理，发现生理活性显著药效活性物质，为开发具有我国独立知识产权的创新药物提供先导化合物。

(2) 海洋微生物复杂活性天然产物的代谢工程和组合生物合成(Metabolic Engineering and Combinatorial Biosynthesis of Complex Bioactive Natural Products)。包括：抗生素生物合成基因簇的克隆、序列测定和生物信息学分析；重要活性化合物产生菌全基因组的序列测定及其功能基因研究；新的生物合成途径的发现及其调控机制；基因阻断、置换、重组或异源表达构建工程菌，产生“非天然”的天然产物或提高目标天然产物的产量；利用基因克隆、蛋白表达、纯化手段，对酶促反应机理和动力学进行表征，发掘新型酶促反应催化剂；重要活性天然产物的体外全生物合成(in vitro total biosynthesis)，体外构建重要天然产物的生物合成途径，用生物酶快速合成天然产物衍生物库。

(3) 抗感染、抗肿瘤海洋药物的成药性评价和药物研发(Anti-infective and Anti-tumor Drug Development)。对通过发现和生物合成技术改造获得的化合物进行构效关系研究，筛选出结构新颖、活性显著、具有自主知识产权的化合物进行体内药效、安全性、质量标准、药代和药剂学等临床前研究，开发抗感染、抗肿瘤海洋药物。

代表性工作简介

主要从事热带海洋微生物来源活性物质的发现和代谢机制研究工作。从热带海洋微生物中筛选发现了具有抗感染、抗肿瘤等活性小分子800余个，开发了海洋微生物的组合生物合成和异源表达技术，阐明了18种特征活性代谢产物的生物合成和代谢机制，揭示了26种新颖生物合成酶的催化功能，筛选出3个自主产权的抗结核杆菌感染、抗胶质瘤和抗白血病候选海洋药物，其中1个正在进行系统临床前研究。在PNAS, Nature Communications, Journal of the American Chemical Society, Angewandte Chemie International Edition, Nature Chemical Biology, Organic Leters.等学术刊物发表SCI论文110篇，论文被SCI引用超过3300次，多篇论文被Nature Chemical Biology, Faculty of 1000和Science-Perspectives等作为研究亮点评述，被自然指数中国增刊评为2014年广州个体科研产出领先者，成果入选 “中国海洋与湖沼学会” 2017年十大科技进展，获授权专利19项。

学习经历

1995.09-2000.07：北京协和医学院/中国医学科学院，理学博士

1991.09-1995.07： 山东大学药学院，理学学士，药学专业

工作经历

2008.03-至今： 中国科学院南海海洋研究所，责任研究员

2003.03-2008.02：美国威斯康星麦迪逊大学药学院，研究助理/助理研究员

2003.03： 中国医学科学院/北京协和医学院药用植物所，副研究员

获奖与荣誉

1. 第五届施维雅青年药物化学奖(2002)、

2. 第七届药明康德生命化学研究奖（2013）

3. 国家杰出青年基金获得者（2014）

4. 中科院特聘研究员骨干人才（2015）

5. 广东省特支计划“百千万工程领军人才”（2016）

6. 广东省特支计划“杰出人才”（南粤百杰）（2017）

学术兼职

1. 农工党广东省第十三届委员会医药卫生工作委员会委员（2017-至今）

2. 中国微生物学会海洋微生物学专业委员会副主任委员（2016-2021）

3. 广东省药学会药物化学专业委员会副主任委员（2019-至今）

4. 中国药学会海洋药物专业委员会委员（2019-至今）

5.《热带海洋学报》副主编（2014-至今）

6.《中国海洋药物》编委（2013-至今）

7. Journal of Natural Products编委（2019-至今）

代表性学术成果

论文发表

85. Changli Sun;+ Zhijie Yang; Chunyan Zhang; Zhiyong Liu; Jianqiao He; Qing Liu; Tianyu Zhang; Jianhua Ju;* Junying Ma.* Genome mining of Streptomyces atratus SCSIO ZH16: discovery of atratumycin and identification of its biosynthetic gene cluster. Organic Letters. 2019, 21, 1453-1457

84. Yunchang Xie;+ Qinglian Li; Xiangjing Qin; Jianhua Ju;* Junying Ma.* Enhancement of himastatin bioproduction via inactivation of atypical repressors in Streptomyces hygroscopicus. Metabolic Engineering Communications 2019, 17: 561

83. Mingwei Shao;+ Junying Ma; Qinglian Li; Jianhua Ju* Identification of the anti-infective aborycin biosynthetic gene cluster from deep sea-derived Streptomyces sp. SCSIO ZS0098 enables production in a heterologous host. Marine Drugs 2019, 17: 127

82. Mengchan Liu;+ Yanxi Jian;+ Yunchang Xie; Junying Ma; Jianhua Ju*. Identification of the actinomycin D biosynthetic pathway from marine-derived Streptomyces costaricanus SCSIO ZS0073. Marine Drugs 2019, 17: 140

81. Chunyan Zhang;+ Wenjuan DIng; Xiangjing Qin; Jianhua Ju* Genome sequencing of Streptomyces olivaceus SCSIO T05 and activated production of lobophorin CR4 via metabolic engineering and genome mining. Marine Drugs. 2019, 17: 593

80. Zhijie Yang;+ Xin Wei; Jianqiao He; Jianhua Ju.*Junying Ma.* Characterization of the noncanonical regulatory and transporter genes in atratumycin biosynthesis and production in a heterologous host. Marine Drugs. 2019, 17: 560

79. Shanwen Zhang;+ Qing Xie; Changli Sun; Xinpeng Tian; Chun Gui; Xiangjing Qin; Hua Zhang;* Jianhua Ju.* Cytotoxic kendomycins containing the carbacylic ansa scaffold from marine-derived Verrucosispora sp. SCSIO 07399. Journal of Natural Products 2019,82,3366-3371

78. Minghe Luo+; Ruochen Zang; Xin Wang; Ziming Chen; Yongxiang Song; Jianhua Ju;* Hongbo Huang.* Natural hydroxamate-containing siderophore acremonpeptides A-D  and an aluminum complex of acremonpeptide D from Marine-derived Acremoniumpersicinum SCSIO 115. Journal of Natural Products 2019, 82, 2594-2600

77. Qinghua Zhu;+ Yongxiang Song; Hongbo Huang; Qinglian Li;* Jianhua Ju* Characterization of MtdV as a chorismate lyase essential to A201A biosynthesis and precursor-directed biosynthesis of new analogs. Organic & Biomolecular Chemistry 2019, 17, 3760-3764

76. Qing Liu;+ Zhiyong Liu; Changli Sun; Mingwei Shao; Junying Ma; Xiaoyi Wei; Tianyu Zhang;* Wenjun Li;* Jianhua Ju.* Discovery and biosynthesis of atrovimycin, an antitubercular and antifungal cyclodepsipeptide featuring vicinal-dihydroxylated cinnamic acyl chain. Organic Letters 2019, 21, 2634-2638

75. Huaqi Pan;+ Xin-Peng Tian; Mingwei Shao; Yunchang Xie; Hongbo Huang; Jiangchun Hu; Jianhua Ju.* Genome mining and metabolic profiling illuminate the chemistry driving diverse biological activities of Bacillus siamensis SCSIO 05746 Applied Microbiology and Biotechnology 2019, 103, 4153-4165

74. Li Qinglian+*, Ding Wenjuan, Yao Ziwei, Tu Jiajia, Wang  Liyan, Huang Hongbo, Li Shengying, Ju Jianhua*. AbmV catalyzes tandem ether installation and hydroxylation during neoabyssomicin/abyssomicin biosynthesis. organic letters. 2018, 20,4854-4857

73. Qin Xiangjing, Xie Yunchnag, Huang Hongbo, Chen Qi, Ma Junying, Li Qinglian, Ju Jianhua*. Enzymatic synthesis of GDP-b-L-fucofuranose by MtdL and Hyg20. organic letters. 2018, 20,1015-1018

72. Zhang Chunyan, Yang Zhijie, Qin Xiangjing, Ma Junying, Sun Changli, Huang Hongbo, Li Qinglian, Ju Jianhua*. Genome mining for mycemycin: discovery and elucidation of related methylation and chlorination biosynthetic chemistries. organic letters. 2018, 20,7633-7636

71. Li Yan, Zhang Chunyan, Liu Chengxiong, Ju Jianhua,* Ma Junying.* Genome sequencing of Streptomyces atratus SCSIO ZH16 and activation production of nocardamine via metabolic engineering. Frontiers in Micrbiology. 2018,9,1269-1278

70. Huang Hongbo., Song Yongxiang, Li Xin, Wang, Xin, Ling Chunyao, Qin Xiangjing, Zhou Zhenbin, Li Qinglian, Wei Xiaoyi, Ju Jianhua*. Abyssomicin monomers and dimers from the marine-derived Streptomyces koyangensis SCSIO 5802. Journal of natural products. 2018, 81,1892-1898

69. Zhang Chunyan, Sun Changli, Gui Chun, Wang Liyan, Huang Hongbo, Li Qinglian, Ju Jianhua.* Biosynthetic Baeyer–Villiger chemistry enables access to two anthracene scaffolds from a single gene cluster in deep sea-derived Streptomyces olivaceus SCSIO T05. Journal of natural products. 2018, 81,1570-1577

68. Gui Chun., Yuan, J., Mo Xuhua, Huang Hongbo, Zhang Shanwen, Gu Yucheng, Ju Jianhua.*. Cytotoxic anthracycline metabolites from a recombinant Streptomyces. Journal of natural products. 2018, 81,1278-1289

67. Sun Jianbin, Shao  Junli, Song Yongxiang, Sun  Changli, Li Qinglian, Lu Laichun, Hu Yunfeng, Zhang Hua,* Ju Jianhua.*  Borrelidins F–I, cytotoxic and cell migration inhibiting agents from mangrove-derived Streptomyces rochei SCSIO ZJ89. Bioorganic & Medicinal Chemistry 2018,26,1488-1494

66. Sun Changli, Zhang Chunyan., Qin Xiangjing., Wei Xiaoyi, Liu Qing, Li Qinglian, Ju Jianhua*. Genome mining of Streptomyces olivaceus SCSIO T05: discovery of olimycins A and B and assignment of absolute configurations. Tetrahedron 2018, 74,199-203

65. Zhang Shanwen, Gui Chun, Shao Mingwei., Kumar, Saravana, Huang Hongbo,* Ju Jianhua.* Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077. Natural Product Research doi:10,1080/14786419,2018,1493736

64. Zhu, Q.; Chen, Q.; Song, Y.; Huang, H.; Li, J.; Ma, J.; Li, Q.; Ju, J.* Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-L-galactose mutase. Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 4948-4953.

63. Ma, J.;* Huang, H.; Xie, Y.; Liu, Z.; Zhao, J.; Zhang, C.; Jia, Y.; Zhang, Y.; Zhang, H.; Zhang, T.; Ju, J.* Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents. Nat. Commun. 2017, 8(1), 391(doi: 10.1038/s41467-017-00419-5).

62. Gui, C.; Mo, X.; Gu, Y.-C.; Ju, J.* Elucidating the sugar tailoring steps in the cytorhodin biosynthetic pathway. Org. Lett. 2017, 19, 5617-5620.

61. Gui, C.; Zhang, S.; Zhu, X.; Ding, W.; Huang, H.; Gu, Y.C.; Duan, Y.; Ju, J.* Antimicrobial spirotetronate metabolites from marine-derived Micromonospora harpali SCSIO GJ089. J. Nat. Prod. 2017, 80, 1594-1603.

60. Luo, M.; Cui, Z.; Huang, H.; Song, X.; Sun, A.; Dang, Y.; Lu, L*; Ju, J.* Amino Acid Conjugated Anthraquinones from the Marine-derived Fungus Penicillium sp. SCSIO sof101. J. Nat. Prod. 2017, 80, 1668-1673.

59. Xie, Y.; Ma, J.; Qin, X.; Li, Q.; Ju, J.* Identification and utilization of two important transporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis. Microb. Cell Fact. 2017, 16(1):177 (doi:10.1186/s12934-017-0792-8).

58. Song, Y.; Li, Q.; Qin, F.; Sun, C.; Liang, H.; Wei, X.; Wong, N.-K.; Ye, L.; Zhang, Y.; Shao, M.; Ju, J.* Neoabyssomicins A–C, polycyclic macrolactones from the deep-sea derived Streptomyces koyangensis SCSIO 5802. Tetrohedron, 2017, 73, 5366-5372.

57. Chen. E; Chen, Q.; Chen, S.; Xu, B.; Ju, J.*; Wang, H.* Discovery and biosynthesis of mathermycin from marine-derived Marinactinospora thermotolerans SCSIO 00652. Appl. Environ. Microbiol. 2017, 83(15), pii: e00926-17 (doi: 10.1128/AEM.00926-17).

56. Li, H.; Huang, H.; Hou, L.; Ju, J.; Li, W.* Discovery of antimycin-type depsipeptides from a wbl gene mutant strain of deep sea-derived Streptomyces somaliensis SCSIO ZH66 and their effects on pro-inflammatory cytokine production. Front Microbiol. 2017, 8, 678.

55. Zhu, X.; Duan, Y.; Cui, Z.; Wang, Z.; Li, Z.; Zhang, Y.; Ju, J.; Huang, H.* Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32. J. Antibiot. 2017, 70, 819-822.

54. Mo, X.*; Shi, C.; Gui, C.; Zhang, Y.; Ju, J.; Wang, Q.* Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster. Microb. Cell Fact. 2017, 16(1):100.

53. Lai, Z.; Yu, J.; Ling, H.; Song, Y.; Yuan, J.; Ju, J.; Tao, Y.;* Huang, H.* Grincamycins I？-？K, cytotoxic angucycline glycosides derived from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. Planta Med. 2017, doi: 10.1055/s-0043-119888.

52. Li, X.; Xia, Z.; Tang, J.; Wu, J.; Tong, J.; Li, M.; Ju, J.; Chen, H.; Wang, L.* Identification and biological evaluation of secondary metabolites from marine derived fungi-Aspergillus sp. SCSIOW3, cultivated in the presence of epigenetic modifying agents. Molecules, 2017, 22(8), pii: E1302 (doi: 10.3390/molecules22081302).

51. Li, Q.; Qin, X.; Liu, J.; Gui, C.; Wang, B.; Li, J.; Ju, J.* Deciphering the biosynthetic origin of L-allo-isoleucine. J. Am. Chem. Soc. 2016, 138, 408-415 (Highlighted in JACS Spotlights, 2016, 138, 461; Hot off the Press in Natural Products Reports, 2016, 33, 530).

50. Luo, M.; Tang, G.; Ju, J.; Lu, L.; Huang, H.* A new diketopiperazine derivative from a deep sea-derived Streptomyces sp. SCSIO 04496. Nat. Prod. Res. 2016, 30, 138-143.

49. Liu, J.; Wang, B.; Li, H.; Xie, Y.; Li, Q.; Qin, X.; Zhang, X.; Ju, J.* Biosynthesis of the anti-infective marformycins featuring pre-NRPS assembly line N-formylation and O-methylation and post-assembly line C-hydroxylation chemistries. Org. Lett. 2015, 17, 1509-1512 (Hot off the Press in Natural Product Reports).

48. Gui, C.; Li, Q.; Mo, X.; Qin, X.; Ma, J; Ju, J.* Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis. Org. Lett. 2015, 17, 628-631.

47. Li, Q,; Song, X.; Qin, X,; Zhang, X.; Sun, A.; Ju, J.^* Identification of the biosynthetic gene cluster for the anti-infective desotamides and production of a new analogue in a heterologous host. 2015, J. Nat. Prod. 2015, 78, 944-948

46. Song, Y.; Liu, G.; Li, J.; Huang, H.; Zhang, X.; Zhang, H.,* Ju, J.* Cytotoxic and antibacterial angucycline- and prodigiosin- analogues from the deep-sea derived Streptomyces sp. SCSIO 11594. Mar. Drugs, 2015, 13, 1304-1316.

45. Medema, M.H.; et al; Xie, Y.; et al; Ju, J.; et al, Gl？ckner, F.O.* Minimum Information about a Biosynthetic Gene cluste. Nat. Chem. Biol. 2015, 11, 625-631.

44. Huang SX, Yun BS, Ma M, Basu HS, Church DR, Ingenhorst G, Huang Y, Yang D, Lohman JR, Tang GL, Ju J, Liu T, Wilding G, Shen B.* Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species. Proc. Natl. Acad. Sci. USA. 2015, 112, 8278-8283.

43. Zhang, Y.; Huang, H.; Xu, S.; Wang, B.; Ju, J; Tan, H.; Li, W.* Activation and enhancement of fredericamycin A production in deepsea-derived Streptomyces somaliensis SCSIO ZH66 by using ribosome engineering and response surface methodology. Microb. Cell Fact. 2015, 14, 64.

42. Song,Y.; Li, Q.; Liu, X.; Chen, Y.; Zhang, Y.; Sun, A.; Zhang, W.; Zhang, J.; Ju, J.* Cyclic hexapeptides from the deep South China Sea-derived Streptomyces scopuliridis SCSIO ZJ46 active against pathogenic Gram-positive bacteria. . Nat. Prod. 2014,77, 1937-1941.

41. Xie, Y.; Li, Q.; Song, Y.; Ma, J.; Ju, J* Involvement of SgvP in carbon–sulfur bond formation during griseoviridin biosynthesis. ChemBioChem, 2014, 15, 1183-1189 (commented by Faculty of 1000).

40. Ji C., Chen Q., Li Q.,Huang H., Song Y., Ma J, Ju J.^* Chemoenzymatic synthesis of new β-carboline derivatives using McbA, an ATP-dependent amide synthetase. Tetrahedron Lett. 2014, 55, 4901-4904.

39. Mo X., Li Q., Ju J.* Naturally occurring tetramic acid products: isolation, structure elucidation and biological activity. RSC Advances. 2014, 4, 50566-50593.

38. Zhou X., Huang H., Li J., Song Y., Jiang R., Liu J., Zhang S., Hua Y.,* Ju J.* New anti-infective cycloheptadepsipeptide congeners and absolute stereo-chemistry from the deep sea-derived Streptomyces drozdowiczii SCSIO 10141. Tetrehedron, 2014, 70, 7795-7801.

37. Seo, J.W.; Ma, M.; Kwong, T.; Ju, J.; Lim, S.K.; Jiang, H.; Lohman, J.R.; Yang, C.; Cleveland, J.; Zazopoulos, E.; Farnet, C.M.; Shen, B.* Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. Biochemistry. 2014, 53(49):7854-7865.

36. Wang, H.; Zhang, H.; Mi, Y.; Ju, J.; Chen, Q.; Zhang, H.* Expression, crystallization and preliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis. Acta Crystallogr F Struct Biol Commun. 2014, 70(Pt 10), 1402-145.

35. Chen, Q.; Ji, C.; Song, Y.; Huang, H.; Ma, J.; Tian, Xi.; Ju, J* Discovery of McbB, a novel enzyme catalyzing the β-Carboline skeleton construction in the marinacarboline biosynthetic pathway. Angew. Chem. Int. Ed., 2013, 52, 9980-9984 (commented by Faculty of 1000). 

34. Zhang, Y.; Huang, H.; Chen, Q.; Luo, M.; Sun, A.; Song, Y.; Ma, J.; Ju, J.* Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety. Org. Lett. 2013, 15, 3254-3257.

33. Wang, B.; Song, Y.; Luo, M.; Chen, Q.; Ma, J.; Huang, H.; Ju, J.* Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation. Org. Lett. 2013, 15, 1278-1281.

32. Song, Y.; Huang, H.; Chen, Y.; Ding, J.; Zhang, Y.; Sun, A.; Zhang, W.; Ju, J.* Cytotoxic and antibacterial marfuraquinocins from the deep South China Sea-derived Streptomyces niveus SCSIO 3406. J. Nat. Prod. 2013, 76, 2263-2268.

31. Zhang, Y.; Zhou, X.; Huang, H.; Tian, X.; Song, Y.; Zhang, S.; Ju, J.* 03219A, a new Δ8,9-pregnene isolated from Streptomyces sp. SCSIO 03219 obtained from a South China Sea sediment. J. Antibiot. 2013, 66, 327-331.

30. Zhang, H.; Chen, J.; Wang, H.; Xie, Y.; Ju, J.; Yan, Y.; Zhang, H.* Structural analysis of HmtT and HmtN involved in the tailoring steps of himastatin biosynthesis. FEBS Lett. 2013, 587, 1675-1680.

29. Ma, M.; Kwong, T.; Lim, S.-K.; Ju, J.; Lohman, J. R.; Shen, B.* Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate speci？city. J. Am. Chem. Soc., 2013, 135, 2489-2492.

28. Mo, X.; Ma, J.; Huang, H.; Wang, B.; Song, Y.; Zhang, S.; Zhang, C.; Ju, J.* ？^11,12-double bond formation in tirandamycin biosynthesis is atypically catalyzed by TrdE, a glycoside hydrolase family enzyme. J. Am. Chem. Soc. 2012, 134, 2844-2847(highlighted in Nat. Chem. Biol. 2012, 8, 320).

27. Zhu,Q.; Li, J.; Ma, J.;Luo, M.;Wang, B.; Huang, H.; Tian, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* Discovery and engineered overproduction of antimicrobial nucleoside antibiotic A201A from deep sea marine actinomycete Marinactinospora thermotolerans SCSIO 00652. Antimicrob. Agents. Chemother. 2012, 56, 110-114.

26. Xie, Y.; Wang, B.; Liu, J.; Zhou, J.; Ma, J.; Huang, H.; Ju, J.* Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis. ChemBioChem, 2012, 13, 2745-2757 (highlighted as an an inside cover).

25. Ma, J.; Zuo, D.; Song, Y.; Huang, H.; Yao, Y.; Li, W.; Zhang, C.; Ju, J.* Characterization of a single gene cluster that is responsible for methylpendolmycin and pendolmycin biosynthesis in the deep sea bacterium Marinactinospora thermotolerans. ChemBioChem, 2012, 13, 547-552.

24. Huang, H.; Yang, T.; Ren, X.; Liu, J.; Song,Y.; Sun, A.; Ma, J.; Zhang, Y.; Huang, C.; Zhang, C.; Ju, J.* Cytotoxic angucycline class glycosides from the deep sea actinomycete Streptomyces lusitanus SCSIO LR32. J. Nat. Prod. 2012, 75, 202-208

23. Chen, Z.; Song, Y.; Chen, Y.; Huang, H.; Zhang, W.; Ju, J.* Cyclic heptapeptides, codyheptapeptides C–E, from marine-derived fungus Acremonium persicinum SCSIO 115. J. Nat. Prod., 2012, 75, 1215-1219. 

22. Huang, H.; Wang, F.; Luo, M.; Chen, Y.; Song, Y.; Wang, B.; Ma, J.; Zhang, W.; Zhang, S.; Ju, J.* Halogenated anthranquinones from the deep sea-derived fungus Aspergillus sp. SCSIO F063.  2012, J. Nat Prod. 75, 1346-1352.

21. Zhou, X.; Huang, H.; Chen, Y.; Tan, J.; Song, Y.; Zou, J.; Tian, X.; Hua, Y.; Ju, J.* Marthiapeptide A, an anti-infective and cytotoxic polythiazole cyclopeptide from a 60-L scale fermentation of the deep sea-derived marinactinospora thermotolerans SCSIO 00652. J. Nat Prod. 2012, 75, 2251-2255.

20. Chen, Z.; Zheng, Z.; Huang, H.; Song, Y.; Zhang, X.; Ma, J.; Wang, B.; Zhang C.; Ju, J.* Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07. Bioorg. Med. Chem. Lett., 2012, 22, 3332-3335.

19. Ma, J.; Wang, Z.; Huang, H.; Zuo, D.; Luo, M.; Wang, B.; Sun, A.; Cheng, Y.; Zhang, C.; Ju, J.* Biosynthesis of himastatin: Assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative steps. Angew. Chem. Int. Ed. 2011, 50, 7797-7802 (commented by Faculty of 1000).

18. Mo, X.; Huang, H.; Ma, J.; Wang, Z.; Wang, B.; Zhang, S.; Zhang, C.; Ju J.* Characterization of TrdL as a 10-hydroxy dehydrogenase and generation of new analogues from a tirandamycin biosynthetic pathway. Org. Lett., 2011, 13, 2212-2215.

17. Huang, H.; Yao, Y.; He, Z.; Yang, T.; Ma, J.; Tian, X.; Li, Y.; Huang, C.; Chen, X.; Li, W.; Zhang, S.; Zhang, C.; Ju, J.* Antimalarial ？-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate. J. Nat. Prod. 2011, 74, 2122-2127 (highlighted by Global Medical Discovery).

16. Mo, X.; Wang, Z.; Wang, B.; Ma, J.; Huang, H.; Tian, X.; Zhang, S.; Zhang, C.; Ju, J.* Cloning and characterization of the biosynthetic gene cluster of the bacterial RNA polymerase inhibitor tirandamycin from marine-derived Streptomyces sp. SCSIO1666. Biochem. Biophy. Res. Commun., 2011, 406, 341-347. 

15. Chen, Z.; Huang, H; Chen, Y.; Wang, Z.; Ma, J.; Wang, B.; Zhang, W.; Zhang, C.; Ju, J.*  New cytochalasins from the marine-derived fungus Xylaria sp. SCSIO 156. Helv. Chim. Acta. 2011, 94, 1671-1676.

14. Huang, Y.; Huang, S. X.; Ju, J.; Tang, G.; Liu, T.; Shen, B.* Characterization of the lnmKLM genes unveiling key intermediates for ？-alkylation in leinamycin biosynthesis. Org. Lett., 2011, 13, 498-501.

Other representative publications：

13. Schneider-Poetsch, T.; Ju, J.; Eyler, D. E.; Dang, Y.; Bhat, S.; Merrick, W. C.; Green, R.; Shen, B.; Liu, J. O*. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nat. Chem. Biol. 2010, 6, 209-217.

12. Ju, J.; Rajski, S.R.; Lim S.K.; Seo, J.W.; Peters, N.R.; Hoffmann, F.M., Shen, B.* Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration. J. Am. Chem. Soc. 2009, 131, 1370-1371.

11. Ju, J.;^# Li, W.;^# (co-first-author) Yuan, Q.; Peters, N.R.; Hoffmann, F.M., Rajski, S.R.; Osada, H.; Shen, B.* Functional characterization of ttmM unveils new tautomycin analogs and insight into tautomycin biosynthesis and activity. Org. Lett., 2009, 11, 1639-1642.

10. Ju, J.; Rajski, S.R.; Lim, S.K.; Seo, J.W.; Peters, N.R.; Hoffmann, F.M., Shen, B*. Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency. Bioorg. Med. Chem. Lett. 2008, 18, 5951-5954.

9. Kennedy, D.R.; Ju, J.; Shen, B.; Beerman, T.A.* Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses. Proc. Natl. Acad. Sci. U.S.A., 2007, 104, 17632-17637.

8. Ju, J.; Seo, J.-W.; Her, Y.; Lim, S.-K; Shen, B*. New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus. Org. Lett., 2007, 9, 5183-5186.

7. Ju, J.; Lim, S.-K; Jiang, H.; Seo, J.-W.; Her, Y.; Shen, B*. Thermolysis of isomigrastatin and its congeners via [3,3]-sigmatropic rearrangement: a new route to the synthesis of migrastatin and its analogues. Org. Lett., 2006, 8, 5865-5868.

6. Ju, J.; Lim, S.K.; Jiang, H.; Seo, J.W.; Shen, B.* Isomigrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds. J. Am. Chem Soc. 2005, 127, 11930-11931.

5. Ju, J.; Lim, S.K.; Jiang, H.; Shen, B.* Migrastatin and dorrigocins are shunt metabolites of iso-migrastatin. J. Am. Chem. Soc. 2005, 127:1622-1623.

4. Ju, J.; Ozanick, S.G.; Shen, B.; Thomas, M.G.* Conversion of (2S)-arginine to (2S, 3R)-capreomycidine by VioC and VioD from the viomycin biosynthetic pathway of Streptomyces sp. strain ATCC11861. ChemBioChem, 2004, 5:1281-1285.

3. Ju, J.*; Liu, D.; Lin, G.; Xu, X.; Han, B.; Yang, J*. Tu, G.; Ma, L.; Beesiosides A-F, Six new cycloartane triterpene glycosides from Beesia calthaefolia.  J. Nat. Prod., 2002, 65, 42-47.

2. Ju, J.*; Liu, D.; Lin, G.; Zhang, Y.; Yang, J.*; Lu, Y.; Gong N.; Zheng, Q. Beesiosides G, H, and J-N, Seven new cycloartane triterpene glycosides from Beesia calthifolia.  J. Nat. Prod., 2002, 65, 147-152.

1. Ju, J.; Yang, J.; Li, J.; Xiao, P. Cypripediquinone A, a new phenanthraquinone from Cypripedium macranthum (Orchidaceae ). Chin. Chem. Lett. 2000, 11(1), 37-38.

授权专利

1. 鞠建华 李青连。氨基转移酶和异构酶在催化形成L-allo-Ile中的应用（日本专利：6565839）

2. 鞠建华，姚月良，田新朋，等。 一种海洋链霉菌以及利用该菌制备替达霉素A和B的方法(授权专利号：ZL 201010565028.1)。

3. 鞠建华，黄洪波，姚月良，等。 β-咔啉生物碱及其在制备抗疟疾药物中的应用(授权专利号：ZL 201110132680.9)。

4. 鞠建华，周俊勇，黄洪波，等。一种海洋链霉菌及利用其制备星形孢菌素和K-252d的方法(授权专利号：ZL 201110065140.3)。

5. 鞠建华, 陈子明, 黄洪波，等。霉酚酸衍生物A、B、C及其在制备免疫抑制药物中的应用(授权专利号：ZL 201110404515.4)。

6. 鞠建华, 朱清华, 李军，等。一种核苷类抗生素A201A高产菌株及其构建方法(授权专利号： ZL 201110340905.X)。

7. 鞠建华, 黄洪波, 任香梅，等。一类角环素类化合物及其在制备抗肿瘤药物中的应用(授权专利号：ZL 201110421665.6)。

8. 鞠建华，谢运昌。绿灰霉素和绿灰霉素的生物合成基因簇及其应用(授权专利号：ZL201210284937.7)。

9. 鞠建华，周潇，黄洪波，等。抗生素Tetrathiazomycin A及其制备方法和在制备抗肿瘤药物中的应用(授权专利号：ZL 201210230665.3)。

10. 鞠建华，张云，黄洪波，等。一种格瑞克霉素和P-1894B的生物合成基因簇及其应用(授权专利号：ZL 201310118576.3)。

11. 鞠建华,陈奇,纪昌涛。一种海洋咔啉生物碱的生物合成基因簇及其应用（PCT专利申请号：201310224447.2）。

12. 鞠建华,宋永相,黄洪波，等。一类吩嗪化合物及其在制备抗肿瘤药物中的应用（授权专利：ZL201310304568.8）

13. 鞠建华,宋永相,黄洪波，等。一类萘醌倍半萜化合物及其在制备抗肿瘤或抗菌药物中的应用（授权专利：ZL 201310304510.3）

14. 鞠建华,丁杰,宋永相。一种生物碱类化合物的制备方法及其在制备抑制钙离子通道药物中的应用（授权专利：ZL 201310367331.4）

15. 张幸，罗明和，鞠建华。一种吲哚-3-甲醛类化合物的制备方法和应用（授权专利号：ZL 201410641080.9）

16. 鞠建华 马俊英 张云 李青连 黄洪波 宋永相 王博 谢运昌。环酯肽类抗生素黑莫他丁的高产菌株及其构建方法（ZL 201410372728.7）

17. 鞠建华，宋永相， 李洁， 黄洪波。一类角环素化合物及其在制备抗肿瘤或抗菌药物中的应用（授权专利：ZL 201510053130.6）

18. 鞠建华，张幸，桂春。一种海洋链霉菌及其应用（授权专利：ZL 201510073450.8）

19. 鞠建华 李青连 秦湘静 刘静。氨基转移酶和异构酶在催化形成L-allo-Ile中的应用（ZL 201510651516.7）

20. 鞠建华，宋永相，许芳，等。一类环六肽化合物及其在制备抗良性前列腺增生药物中的应用（ZL 201510725256.3）

21. 鞠建华，朱清华，黄洪波，宋永相，马俊英，李青连。一类核苷类抗生素及其在制备抗菌药物中的应用（ZL 201510460273.9）

22. 鞠建华，马俊英, 黄洪波、贾艳玺、张春燕。环肽类化合物在制备抗肿瘤药物中的应用（ZL 2016108055497）

23. 鞠建华 马俊英 黄洪波 张春燕 贾艳玺 李岩。一种定向生产抗结核活性和抗肿瘤活性化合物的基因工程菌株及其应用（ZL 2016108851044）

24. 鞠建华，张天宇，马俊英，刘志永（中国科学院南海海洋研究所; 中国科学院广州生物医药与健康研究院）。一种海洋链霉菌、及其环肽化合物在制备抗结核分枝杆菌药物中的应用（ZL 2016108067371）

25. 鞠建华; 桂春; 李青连; 程伟鸽。一种海洋链霉菌及其在制备那西肽中的应用（ZL 2016104805901）

26. 鞠建华; 宋永相; 谢运昌; 秦湘静。一种利用深海链霉菌SCSIO 5604制备抗生素dihydrotetrodecamycin的方法（ZL 2016102729532）

学科组建设

责任研究员：鞠建华

研究员：马俊英

副研究员：宋永相、李青连、孙长利（项目，特别研究助理）

助理研究员：秦湘静

特别研究助理：李骏

行政人员：赵红梅

博士后：Saravana kumar、Ganesan Govindarajan、刘晴、张雪佳、邵明伟

博士研究生：丁文娟（2016直博生）、陈姜（2017直博生）、周镇槟（2018直博生)、张华然（2019）

硕士研究生：纪晓奇（2017）、姚紫薇（2018）、吴巧玲（2019）

已培养博士研究生9名；硕士研究生14名