刘永宏研究员

广东省海洋药物重点实验室 副主任

（海洋天然药物化学学科组责任研究员 yonghongliu@scsio.ac.cn）

研究兴趣与领域

1. 海洋微生物来源的药用和生态活性成分研究

2. 海洋活性天然产物的结构修饰与合成

代表性工作简介

主要研究领域为海洋特殊环境微生物来源的活性物质和药物先导物研究。近5年从海洋微生物中分离发现活性小分子化合物500多个，其中新化合物300多个；筛选发现具有药用活性的先导化合物50多个；对发现的重要活性先导化合物进行系统的结构修饰或合成研究，探讨相关衍生物的构效关系，优化先导化合物，发现5个/类结构新颖、高效低毒的新药研究目标分子，为海洋微生物资源的高效利用和我国海洋药物研发作出贡献。

学习经历

1992-1996：长春中医药大学，中药学学士

1996-1999：长春中医药大学，天然药物化学硕士

1999-2002：韩国釜山大学，海洋天然药物化学博士

工作经历

2002-2003：韩国釜山大学药学大学，博士后

2003-2004：日本大阪大学药学大学，博士后

2004-2005：葡萄牙里斯本新大学科技学院化学系，博士后

2006-至今：中国科学院南海海洋研究所 研究员 博士生导师

获奖与荣誉

1. 国家科技进步二等奖（第十二，2007）

2. 海南省科技进步一等奖（第十四，2010）

3. 吉林省科学技术进步二等奖（第三，2011）

4. 广东省科协系统先进工作者（2013）

5. 广州科技创新联盟南山奖（2014）

6. 全国优秀科技工作者（2014）

7. 中国科学院广州分院优秀研究生导师（2014）

8. 吉林省科学技术进步二等奖（第二，2014）

9. 吉林省科学技术进步二等奖（第五，2015）

10.广东省特支计划“百千万工程领军人才”（2017）

学术兼职

1. 广东省腐蚀防护与表面工程学会副理事长（2018-2022）

2. 广州市腐蚀与防护学会副理事长（2018-2022）

3. 广东省保健协会中草药分会副主任委员（2017-2021）

4. 中国药理学会海洋药物药理专业委员会常务委员（2018-2021）

5. 中国药学会海洋药物专业委员会委员（2016-2020）

6. 广东省药学会药物化学专业委员会委员（2018-2020）

7. 《中国海洋药物》编委（2013-至今）

8. 《天然产物研究与开发》编委（2016-至今）

9. 《药学学报》编委（2017-至今）

10.Journal of Chemical Science and Technology 编委（Editorial Board/Reivewers）（2012-至今）

11.Medicinal Chemistry 编委（Editorial Board）（2012-至今

12.Natural Product Research 编委（Editorial Board）（2013-至今）

13.Chemistry & Biodiversity 编委（Editorial Advisory Board Member）（2017-至今）

代表性学术成果

论文发表

Cui Guo, Pei Wang, Xiuping Lin, Limbadri Salendra, Fandong Kong, Shengrong Liao,  Bin Yang, Xuefeng Zhou, Junfeng Wang* and Yonghong Liu*. Phloroglucinol heterodimers and bis-indolyl alkaloids from the sponge-derived fungus Aspergillus sp. SCSIO 41018？. Organic Chemistry Frontiers. 2019, 6, 3053-3059

Luo Xiaowei; Chen Chunmei; Tao Huaming; Lin Xiuping; Yang Bin; Zhou Xuefeng*; Liu Yonghong*. Structurally diverse diketopiperazine alkaloids from the marine-derived fungus Aspergillus versicolor SCSIO 41016. Organic Chemistry Frontiers. 2019, 6: 736-740

Li Kunlong, Liang Zhi, Chen Weihao, Luo Xiaowei, Fang Wei, Liao Shengrong, Lin Xiuping, Yang Bin, Wang Junfeng, Tang Lan,* Liu Yonghong,* and Zhou Xuefeng*. Iakyricidins A？D, antiproliferative piericidin analogs bearing carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. The Journal of Organic Chemistry. 2019, 84 (19): 12626-12631

Salendra L+, Luo Xiaowei+, Lin Xiuping, Wang Junfeng, Yang Bin, Zhou Xuefeng, Liu Yonghong*. Versispiroketal A, an unusual tetracyclic bridged spiroketal from the sponge-associated fungus Aspergillus versicolor SCSIO 41013. Organic & Biomolecular Chemistry. 2019, 17, 2182–2186

Nianzhen Liu+, Shuai Peng+, Jie Yang, Ziwen Cong, Xiuping Lin, Shengrong Liao, Bin Yang, Xuefeng Zhou, Xiaojiang Zhou？, Yonghong Liu*, Junfeng Wang*. Structurally diverse sesquiterpenoids and polyketides from a spongeassociated fungus Aspergillus sydowii SCSIO41301. Fitoterapia. 2019, 135, 27-32

Luo Xiao-Wei; Lin Yun; Lu Yong-Jun; Zhou Xue-feng*; Liu Yong-hong*. Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chinese Journal of Natural Medicines. 2019, 17(2): 149-154

Mangaladoss Fredimoses, Xuefeng Zhou, Wen Ai, Xinpeng Tian, Bin Yang, Xiuping Lin, Juan Liu, Yonghong Liu*. Emerixanthone E, a new xanthone derivative from deep sea fungus Emericella sp SCSIO 05240. Natural Product Research. 2019, 33:14, 2088-2094

Xiaoyan Pang, Guodi Cai, Xiuping Lin, Limbadri Salendra, Xuefeng Zhou, Bin Yang , Junjian Wang, JunfengWang*, Shihai Xu* and Yonghong Liu*. New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015. Marine Drugs. 2019, 17, 398

Huayan Xu, Liang Xu, Xiaowei Luo, Junfeng Wang, Xuefeng Zhou, Bin Yang, Ding Li*, Zaigang Luo*, Yonghong Liu*, Shengrong Liao*. Transition-metal-free insertion of benzyl bromides into 2-(1H-benzo[d]imidazol-1-yl) benzaldehyde: One-pot switchable syntheses of benzo[4,5]imidazo[1,2-a]quinolin-5(7H)-ones and 3-arylquinolin-4-ones mediated by base. Tetrahedron. 2019, 75, 2785-2796

Hui Lei+ , Jing Lei+, Xuefeng Zhou, Mei Hu, Hong Niu, Can Song, Siwei Chen, Yonghong Liu* and Dan Zhang*. Cytotoxic Polyketides from the Marine Sponge-Derived Fungus Pestalotiopsis heterocornis. Molecules. 2019, 24, 2655

Xiao-Wei Luo, Cheng-Hai Gao, Fang-Hai Han, Xian-Qiang Chen, Xiu-Ping Lin, Xue-Feng Zhou, Jun-Jian Wang*, Yong-Hong Liu*. A new naphthopyranone from the sponge-associated fungus Penicillium sp. XWS02F62. Magnetic Resonance in Chemistry. 2019; 57: 982-986

Xiaoyan Pang, Xiuping Lin, Pei Wang, Xuefeng Zhou, Bin Yang, Junfeng Wang*, Yonghong Liu* Perylenequione derivatives with anticancer activities isolated from the marine sponge-derived fungus, Alternaria sp. SCSIO41014. Marine Drugs. Marine Drugs 2018,16,280-292

Xiaowei Luo+, Jie Yang+, Feimin Chen, Xiuping Lin, Chunmei Chen, Xuefeng Zhou*, Shuwen Liu*, Yonghong Liu* Structurally diverse polyketides from the mangrove-derived fungus Diaporthe sp. SCSIO 41011 with their anti-influenza A virus activities. Frontiers in Chemistry 2018,6:282

Xiaoyan Pang, Xiuping Lin, Jie Yang, Xuefeng Zhou, Bin Yang, Junfeng Wang*, Yonghong Liu*. Spiro-Phthalides and isocoumarins isolated from the marine sponge-derived fungus Setosphaeria sp. SCSIO41009. Journal of Natural Products 2018,81,1860-1868

Xiaowei Luo, Xiuping Lin, Huaming Tao, Junfeng Wang, Jiayi Li, Bin Yang, Xuefeng Zhou*, Yonghong Liu* Isochromophilones A–F, cytotoxic chloroazaphilones from the marine mangrove endophytic fungus Diaporthe sp. SCSIO 41011. Journal of Natural Products 2018,81(4):934-941

Yongqi Tian, Xiuping Lin, Xuefeng Zhou*, Yonghong Liu*. Phenol derivatives from the sponge-derived fungus Didymellaceae sp. SCSIO F46. Frontiers in Chemistry 2018,6:536

Lishu Wang, Jungfeng Wang, Juan Liu, and Yonghong Liu* Antitubercular Marine Natural Products. Current Medicinal Chemistry 2018,25,2304-2328

Dai, Yu, Lin, Yun, Pang, Xiaoyan, Luo, Xiaowei, Salendra, Limbadri, Wang, Junfeng, Zhou, Xuefeng, Lu, Yongjun, Yang, Bin*, Liu, Yonghong* Peptides from the Soft Coral-associated Fungus Simplicillium sp. SCSIO41209. Phytochemistry 2018,154,56-62

Limbadri, Salendra, Luo, Xiaowei, Lin, Xiuping, Liao, Shengrong, Wang, Junfeng, Zhou, Xuefeng, Yang, Bin*, Liu, Yonghong* Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012. Molecules 2018,23,2379

Jun-Feng Wang,* Li-Man Zhou, Sheng-Tian Chen, Bin Yang, Sheng-Rong Liao, Fan-Dong Kong, Xiu-Ping Lin, Fa-Zuo Wang, Xue-Feng Zhou, Yong-Hong Liu* New chlorinated diphenyl ethers and xanthones from a deep-sea-derived fungus Penicillium chrysogenum SCSIO 41001. Fitoterapia 2018,125,49-54

Xiaoyan Pang, Xiuping Lin, Junfeng Wang*, Rui Liang, Yongqi Tian, Limbadri Salendra, Xiaowei Luo, Xuefeng Zhou, Bin Yang, Zhengchao Tu, Yonghong Liu* Three new highly oxygenated sterols and one new dihydroisocoumarin from the marine sponge-derived fungus Cladosporium sp. SCSIO41007. Steroids. 2018,129,41-46

Yang, Bin, Tao, Huaming, Lin, Xiuping, Wang, Junfeng, Liao, Shengrong, Dong, Junde, Zhou, Xuefeng, Liu, Yonghong*. Prenylated indole alkaloids and chromone derivatives from the fungus Penicillium sp. SCSIO041218. Tetrahedron 2018,74,77-82

Yaping Chen, Ruyan Chen, Jinhuai Xu, Yongqi Tian,*, Jiangping Xu,* and Yonghong Liu*. Two New Altenusin/Thiazole Hybrids and a New Benzothiazole Derivative from the Marine Sponge-Derived Fungus Alternaria sp. SCSIOS02F49. Molecules 2018,23,2844

Xiaoyan Pang, Xiuping Lin, Yongqi Tian, Rui Liang, Junfeng Wang, Bin Yang, Xuefeng Zhou, Kumaravel Kaliyaperumal, Xiaowei Luo, Zhengchao Tu, Yonghong Liu* Three new polyketides from the marine sponge-derived fungus Trichoderma sp. SCSIO41004. Natural Product Research 2018,32,105-111

Xiaowei Luo, Xuefeng Zhou*, Yonghong Liu* Nitrogenous compounds produced by the deep sea derived fungus Leptosphaeria sp. SCSIO 41005. Natural Product Communications 2018,13:677-678

Yong-Qi Tian, Sheng-Nan Lin, Hong Zhou, Shu-Ting Lin, Shao-Yun Wang & Yong-Hong Liu* Protuboxepin C and protuboxepin D from the sponge-derived fungus Aspergillus sp SCSIO XWS02F40. Natural Product Research 2018,32:2510-2515

Yong-Qi Tian, Shu-Ting Lin, Kaliaperumal Kumaravel, Hong Zhou, Shao-Yun Wang, Yong-Hong Liu* Polyketide-derived metabolites from the sponge-derived fungus Aspergillus sp. F40. Phytochemistry Letters 2018,27:74-77

Cui Guo, Pei Wang, Xiuping Lin, Limbadri Salendra, Fandong Kong, Shengrong Liao,  Bin Yang, Xuefeng Zhou, Junfeng Wang* and Yonghong Liu*. Phloroglucinol heterodimers and bis-indolyl alkaloids from the sponge-derived fungus Aspergillus sp. SCSIO 41018？. Organic Chemistry Frontiers 2019, 6, 3053-3059

Luo Xiaowei; Chen Chunmei; Tao Huaming; Lin Xiuping; Yang Bin; Zhou Xuefeng*; Liu Yonghong* Structurally diverse diketopiperazine alkaloids from the marine-derived fungus Aspergillus versicolor SCSIO 41016. Organic Chemistry Frontiers 2019, 6: 736~740.

Li Kunlong, Liang Zhi, Chen Weihao, Luo Xiaowei, Fang Wei, Liao Shengrong, Lin Xiuping, Yang Bin, Wang Junfeng, Tang Lan,* Liu Yonghong,* and Zhou Xuefeng*. Iakyricidins A？D, antiproliferative piericidin analogs bearing carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104. The Journal of Organic Chemistry 2019, 84 (19): 12626？12631

Salendra L+, Luo Xiaowei+, Lin Xiuping, Wang Junfeng, Yang Bin, Zhou Xuefeng, Liu Yonghong* Versispiroketal A, an unusual tetracyclic bridged spiroketal from the sponge-associated fungus Aspergillus versicolor SCSIO 41013. Organic & Biomolecular Chemistry 2019, 17, 2182–2186.

Wang Jianjiao, Li Kunlong, Luo Xiaowei, Wu Zhaoyuan, Gu Tanwei, Liao Shengrong, Lin Xiuping, Yang Bin, Liu Yonghong, Fang Wei*, Zhou Xuefeng*. Sorbicillfurans A and B, two novel sorbicillinoid adducts from the fungus Penicillium citrinum SCSIO41402. Organic & Biomolecular Chemistry 2019, 17: 8721？8725.

Nianzhen Liu+, Shuai Peng+, Jie Yang, Ziwen Cong, Xiuping Lin, Shengrong Liao, Bin Yang, Xuefeng Zhou, Xiaojiang Zhou？, Yonghong Liu*, Junfeng Wang* Structurally diverse sesquiterpenoids and polyketides from a spongeassociated fungus Aspergillus sydowii SCSIO41301. Fitoterapia 2019, 135, 27-32

Luo Xiao-Wei; Lin Yun; Lu Yong-Jun; Zhou Xue-feng*; Liu Yong-hong* Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. Chinese Journal of Natural Medicines 2019, 17(2): 149~154

Ziwen Cong, Xiaolong Huang*, Yunhao Liu, Yuxuan Liu, Pei Wang, Shengrong Liao, Bin Yang, Xuefeng Zhou, Dongyi Huang, Junfeng Wang* Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399. The Journal of Antibiotics 2019, 72:45–49

Lin Xiuping+; Li Kunlong+; Yang Lilin; Peng Xiaoying; Fang Wei; Tian Xinpeng*; Liu Yonghong; Zhou Xuefeng*. Dereplication and targeted isolation of bioactive sulphur compound from bacteria isolated from a hydrothermal field. Natural Product Research 2019, 33(4): 494–499.

Mangaladoss Fredimoses, Xuefeng Zhou, Wen Ai, Xinpeng Tian, Bin Yang, Xiuping Lin, Juan Liu, Yonghong Liu* Emerixanthone E, a new xanthone derivative from deep sea fungus Emericella sp SCSIO 05240. Natural Product Research 2019, 33:14, 2088-2094

Xiaoyan Pang, Guodi Cai, Xiuping Lin, Limbadri Salendra, Xuefeng Zhou, Bin Yang , Junjian Wang, JunfengWang*, Shihai Xu* and Yonghong Liu* New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015. Marine Drugs 2019, 17, 398.

Huayan Xu, Liang Xu, Xiaowei Luo, Junfeng Wang, Xuefeng Zhou, Bin Yang, Ding Li*, Zaigang Luo*, Yonghong Liu*, Shengrong Liao*.  Transition-metal-free insertion of benzyl bromides into 2-(1H-benzo[d]imidazol-1-yl) benzaldehyde: One-pot switchable syntheses of benzo[4,5]imidazo[1,2-a]quinolin-5(7H)-ones. Tetrahedron 2019, 75, 2785-2796.

Hui Lei+ , Jing Lei+, Xuefeng Zhou, Mei Hu, Hong Niu, Can Song, Siwei Chen, Yonghong Liu* and Dan Zhang* Cytotoxic Polyketides from the Marine Sponge-Derived Fungus Pestalotiopsis heterocornis XWS03F09. Molecules 2019, 24, 2655

Xiao-Wei Luo, Cheng-Hai Gao, Fang-Hai Han, Xian-Qiang Chen, Xiu-Ping Lin, Xue-Feng Zhou, Jun-Jian Wang*, Yong-Hong Liu* A new naphthopyranone from the sponge-associated fungus Penicillium sp. XWS02F62. Magnetic Resonance in Chemistry 2019; 57: 982-986

Junfeng Wang, Ziwen Cong, Xiaolong Huang,* Chenxi Hou, Weihao Chen, Zhengchao Tu,Dongyi Huang, and Yonghong Liu* Soliseptide A, A Cyclic Hexapeptide Possessing Piperazic Acid Groups from Streptomyces solisilvae HNM30702. Organic Letters 2018,20,1371？1374

Junfeng Wang, Weijun He, Fandong Kong, Xinpeng Tian, Pei Wang, Xiaojiang Zhou, *
and Yonghong Liu*. Ochracenes A？I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis. Journal of Natural Products. 2017,80(6):1725-1733

Lishu Wang, Jungfeng Wang, Juan Liu, Yonghong Liu*. Antitubercular Marine Natural Products.  Current Medicinal Chemistry. 2017,24:1-25

Xiuping Lin+, Qinyu Wu+, Yuying Yu, Zhi Liang, Yonghong Liu, Lili Zhou*, Lan Tang* & Xuefeng Zhou*.  Penicilliumin B, a novel sesquiterpene methylcyclopentenedione from a deep sea-derived Penicillium strain with renoprotective activities.  Scientific Reports. 2017,7:10757

Xiaowei Luo, Xiuping Lin, Limbadri Salendra, Xiaoyan Pang, Yu Dai, Bin Yang, Juan Liu, Junfeng Wang, Xuefeng Zhou*; Yonghong, Liu*. Isobenzofuranones and isochromenones from the deep-sea derived fungus Leptosphaeria sp. SCSIO 41005.  Marine Drugs. 2017,15(7):204

Jun-Feng Wang, Rui Liang, Sheng-Rong Liao, Bin Yang, Zheng-Chao Tu, Xiu-Ping Lin,
Bin-Gui Wang, Yonghong Liu*.  Vaccinols J–S, ten new salicyloid derivatives from the marine mangrovederived endophytic fungus Pestalotiopsis vaccinii.  Fitoterapia. 2017,120:164-170

Sheng-Rong Liao+, Yong Tang+, Liang Xu, Xue-Feng Zhou, Jun-Feng Wang, Bin Yang,
Yong-Hong Liu*.  Ring-contraction from benzo[b][1,4]thiazines to benzo[d]thiazolines induced by oxygen. Tetrahedron. 2017,73:98-107

Bin Yang+, Huaming Tao+, Xiao-Chu Qin, Zhen Wang, Junde Dong, Xiuping Lin, Xuefeng Zhou, Jian-Lin Li, Zheng-Chao Tu & Yonghong Liu*. Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample. Journal of Antibiotics. 2017,70:788-790.

Wei-Jun He+, Xiao-Jiang Zhou+, Xiao-Chu Qin, Yong-Xin Mai, Xiu-Ping Lin, Sheng-Rong Liao, Bin Yang, Tianyu Zhang, Zheng-Chao Tu, Jun-Feng Wang* and Yonghong Liu*. Quinone/hydroquinone meroterpenoids with antitubercular and cytotoxic activities produced by the sponge-derived fungus Gliomastix sp. ZSDS1-F7. Natural Product Research. 2017,31(5):604-609.

Xiaowei Luo, Xuefeng Zhou, Xiuping Lin, Xiaochu Qin, Tianyu Zhang, Junfeng Wang, Zhengchao Tu, Bin Yang, Shengrong Liao, Yongqi Tian, Xiaoyan Pang, Kumaravel Kaliyaperumal, Jianlin Li, Huaming Tao*, Yonghong Liu. Antituberculosis compounds from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. Natural Product Research. 2017,31(16):1958-1962.

Zhi-Ran Ju, Xiu-Ping Li, Minke Li, Ying Wang, Yong-Qi Tian, Jun-Feng Wang, Juan Liu, Zhengchao Tu, Shi-Hai Xu,* and Yonghong Liu*. Chaetochromones A – C, Three New Polyketides from Mangrove Plant Derived Endophytic Fungus Phomopsis sp. SCSIO 41006. Chemistry & Biodiversity. 2017,14(11), e1700266

Yinglei Li, Junfeng Wang, Weijun He, Xiuping Lin, Xiaojiang Zhou, Yonghong Liu*. One Strain-Many Compounds Method for Production of Polyketide Metabolites Using the Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3. Chemistry of Natural Compounds. 2017,53(2),373–374

Wang JF, He W, Huang X, Tian X, Liao S, Yang B, Wang F, Zhou XJ, Liu Y*. Antifungal new oxepine-containing alkaloids and xanthones from the deep-sea-derived fungus Aspergillus versicolor SCSIO 05879. Journal of Agricultural and Food Chemistry, 2016, on line.

Wang JF, Qin XC, Chen Z, Ju Z, He W, Tan Y, Zhou XJ, Tu ZC, Lu F*, Liu Y*. Two new anthraquinones with antiviral activities from the barks of Morinda citrifolia (Noni). Phytochemistry Letters, 2016, 15, 13-15.

Wang J, Wei X, Qin X, Tian X, Liao L, Zhou X, Yang X, Wang F, Tu Z, Chen B, Liu Y.* Antiviral merosesquiterpenoids produced by an antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702. Journal of Natural Products, 2016, 79(1), 59-65.

Zhou X, Fang W, Tan S, Lin X, Xun T, Yang B, Liu S, Liu Y.* Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. Bioorganic & Medicinal Chemistry Letters, 2016, 26, 361-365.

Tian Y, Lin X, Wang Z, Zhou X, Qin X, Kaliyaperumal K, Zhang T, Tu Z, Liu Y.* Asteltoxins with antiviral activities from the marine sponge-derived fungus Aspergillus sp. SCSIO XWS02F40. Molecules, 2016, 21(1), 34, doi:10.3390/molecules21010034

Liao S , Du L, Qin X, Xu L, Wang J, Zhou X, Tu Z, Li J*, Liu Y*. Site selective synthesis of cytotoxic 1,3,6-trisubstituted 3,6-diunsaturated (3Z,6Z)-2,5-diketopiperazines via a one-pot multicomponent method. Tetrahedron, 2016, 72(8), 1051-1057.

New phenyl derivatives from endophytic fungus Botryosphaeria sp SCSIO KcF6 derived of mangrove plant Kandelia candel. Ju ZR, Qin XC, Lin XP, Wang JF, Kaliyaperumal K, Tian YQ, Liu J, Liu F, Tu ZC, Xu SH, Liu Y*. Natural Product Research, 2016, 30(2), 192-198.

Yang B, Huang J, Lin X, Zhang Y, Tao H, Liu Y*. A new diketopiperazine from the marine sponge Callyspongia species. Records of Natural Products, 2016, 10 (1), 117-121.

Wang J, Wei X, Qin X, Lin X, Zhou X, Liao S, Yang B, Liu J, Tu Z, Liu Y*. Arthpyrones A–C, Pyridone alkaloids from a sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Organic Letters, 2015, 17, 656？659.

Liao S, Xu Y, Tang Y, Wang J, Zhou X, Xu L, Liu Y*. Design, synthesis and biological evaluation of soluble 2,5-diketopiperazines derivatives as potential antifouling agents. RSC Advances 2015, 5, 5, 51020–51026

Wang JF, He WJ, Qin XC, Wei XY, Tian XP, Liao L, Liao SR, Yang B, Tu ZC, Chen B, Wang FZ, Zhou XJ, Liu Y*. Three new indolyl diketopiperazine metabolites from the antarctic soil-derived fungus Penicillium sp SCSIO 05705. RSC Advances, 2015, 5(84), 68736-68742.

Zhang J, Lin X, Li L, Zhong B, Liao X, Liu Y*, Xu S* Gliomasolides A–E, unusual macrolides from a sponge-derived fungus Gliomastix sp. ZSDS1-F7-2？ RSC Advances 2015, 5, 54645–54648

Bai Z, Lin X, Wang J, Zhou X, Liu J, Yang Y, Yang X, Liao S, Wang L, Liu Y.* New meroterpenoids from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius. Marine Drugs, 2015, 13, 237-248.

Liu J, Wei X, Kim E, Lin X, Yang X, Zhou X, Yang B, Jung J, Liu Y.* New glucosidated pyrazinoquinazoline indole alkaloids from fungus Aspergillus fumigatus derived of a jellyfish. Tetrahedron, 2015, 71, 271-275.

Wang J, Wang Z, Ju Z, Wan J, Liao S,  Lin X, Zhang T, Zhou X, Chen H, Yang B, Tu Z, Liu Y.* Cytotoxic cytochalasins from marine-derived fungus Arthrinium arundinis ZSDS1-F3. Planta Medica, 2015, 81, 160-166.

Li J, Huang L, Liu J, Song Y, Gao J, Jung J, Liu Y*, Chen G*. Acetylcholinesterase inhibitory dimeric indole derivatives from the marine actinomycetes Rubrobacter radiotolerans, Fitoterapia 2015, 102, 203-207.

Wang JF, Yang SH, Liu YQ, Li DX, He WJ, Zhang XX, Liu Y*, Zhou XJ*. Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium. Bioorganic & Medicinal Chemistry Letters, 2015, 25(9), 1986-1989.

Wang L, Wang J, Wang L, Ma S, Liu Y.* Anti-enterovirus 71 agents of natural products. Molecules 2015, 20(9), 16320-16333.

Qin C, Lin X, Lu X, Wan J, Zhou X, Liao S, Tu Z, Xu S, Liu Y.* Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2. The Journal of Antibiotics 2015, 68， 121-125

Ai W, Lin L, Wang Z, Lu X, Mangaladoss F, Yang X, Zhou X, Tu Z, Liu Y.* Cladosporone A, a new dimeric tetralone from fungus Cladosporium sp. KcFL6’ derived of mangrove plant Kandelia candel. The Journal of Antibiotics 2015, 68, 213-215.

Tian Y, Qin X, Lin X, Kumaravel K, Zhou X, Liu J, Ju Z, Tu Z, Liu Y.* Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The Journal of Antibiotics 2015, 68, 703-706.

Ju ZR, Lin XP, Lu X, Tu ZC, Wang JF, Kaliyaperumal K, Liu J, Tian YQ, Xu SH  Liu Y.* Botryoisocoumarin A, a new COX-2 inhibitor from the mangrove Kandelia candel endophytic fungus Botryosphaeria sp KcF6. The Journal of Antibiotics 2015, 68, 653-656.

Ai W, Lin X, Tu Z, Tian X, Lu X, Mangaladoss M, Zhong J, Liu Y.* Axinelline A, a new COX-2 inhibitor from Streptomyces axinellae SCSIO02208. Natural Product Research 2015, 68, 213-215.

Tian Y, Lin X, Liu J, Kaliyaperumal K, Ai W, Ju J, Yang Y, Wang J, Yang X, Liu Y.* Ascomycotin A, a new citromycetin analogue produced by Ascomycota sp. Ind19F07 isolated from deep sea sediment. Natural Product Research 2015, 29(9), 820-826.

Sun J, Yang B, Zhou X, Yang X, Wang L, Liu Y.* A new briarane-type diterpenoid from the South China Sea Gorgonian Dichotella gemmacea. Natural Product Research 2015, 29(9), 807-812.

Fredimoses M, Zhou X, Ai W, Tian X, Yang B, Lin X, Xian J, Liu Y.* Westerdijkin A, a new hydroxyphenylacetic acid derivative from deep sea fungus Aspergillus westerdijkiae SCSIO 05233. Natural Product Research 2015, 29(2), 158-162.

Wang J, Qin X, Xu F, Zhang T, Liao S, Lin X, Yang B, Liu J, Wang L, Tu Z, Liu Y*. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation. Natural Product Research 2015, 29(18), 1761-1765.

Yang B, Huang JX, Lin XP, Liao SR, Zhou XF, Liu J, Wang JF, Wang LS, Liu Y*. New casbane diterpenoids from the Hainan soft coral Sinularia species. Helvetica Chimica Acta, 2015, 98(6), 834-841.

Wang, JF, Wei XY, Qin XC, Chen H, Lin XP, Zhang TY, Yang XW, Liao SR, Yang B, Liu J, Zhou XF, Tu ZC, Liu Y*. Two new prenylated phenols from endogenous fungus Pestalotiopsis vaccinii of mangrove plant Kandelia candel (L.) Druce. Phytochemistry Letters, 2015, 12, 59-62.

Huang, RM, Chen, YN, Zhou, XF, Yang, XW, Liu, Y*. A new N-Acyl taurine from the South China Sea marine sponge Callyspongia sp. Chemistry of Natural Compounds, 2015, 51(3), 540-541.

Sun J, Wu Y, Yang B, Liu Y.* Chemical constituents of marine sponge Halichondria sp. from South China Sea. Chemistry of Natural Compounds 2015, 51(5), 975-977.

Wang H, Hong J, Yin J, Moon H, Liu Y, Wei X, Oh D, Jung JH. Dimeric Octaketide spiroketals from the jellyfish-derived fungus Paecilomyces variotii J08NF-1, Journal of Natural Products, 2015, 78(11), 2832-2836.

Yang X, Miao Z, Ma X, Zhang G, Steinmetz A, Yang B, Wang J, Liu J, Liu Y, Wang N. Asterolloside, a novel enolic saccharide from the sea star Asterias rollestoni Bell. Tetrahedron Letters, 2015, 56, 6174-6176.

Wang J, He W, Zhang X, Zhao B, Liu Y, Zhou X*. Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L. Bioorganic & Medicinal Chemistry Letters, 2015, 25, 4082-4084.

Wang B, Wang L, Li Y, Liu Y*. Heterocyclic terpenes: linear furano-and pyrroloterpenoids. RSC Advances 2014, 4, 12216-12234.

Lei H, Sun S, Han Z, Zhou X, Yang B, Liu Y*. Fragilisinins A-L, new briarane-type diterpenoids from gorgonian Junceella fragilis. RSC Advances 2014, 4(10), 5261-5271.

Wang L, Zhou X, Fredimoses M, Liao S, Liu Y*. Naturally occurring organoiodines, RSC Advances 2014, 4 (101), 57350- 57376.

Fredimoses M, Zhou X, Lin X, Tian X, Ai W, Wang W, Liao S, Liu J, Yang B, Yang X, Liu Y.* New prenylxanthones from the deep-sea derived fungus Emericella sp. SCSIO 05240. Marine Drugs 2014, 12(6), 3190-3202.

Yang B, Wei X, Huang J, Lin X, Liu J, Liao S, Wang J, Zhou X, Wang L, Liu Y*. Sinulolides A-H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp. Marine Drugs, 2014, 12(10), 5316-5327.

Liao S, Qin X, Li D, Tu Z, Li J, Zhou X, Wang J, Yang B, Lin X, Liu J, Yang X, Liu Y*. Design and synthesis of novel soluble 2,5-diketopiperazine derivatives as potential anticancer agents. European Journal of Medicinal Chemistry, 2014, 83, 236-244.

Yang B, Dong J, Lin X, Zhou X, Zhang Y, Liu Y*. New prenylated indole alkaloids from fungus Penicillium sp. derived of mangrove soil sample. Tetrahedron, 2014, 70(25), 3859–3863.

Ai W, Wei X, Lin X, Sheng L, Wang Z, Tu Z, Yang X, Zhou X, Li J, Liu Y.* Guignardins A-F, spirodioxynaphthalenes from the endophytic fungus Guignardia sp KcF8 as a new class of PTP1B and SIRT1 inhibitors. Tetrahedron, 2014, 70(35), 5806-5814.

Wang J, Wei X, Lu X, Xu F, Wan J, Lin X, Zhou X, Liao S, Yang B, Tu Z, Liu Y.* Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel (L.) Druce. Tetrahedron, 2014, 70, 9695-9701.

Fang W, Lin X, Zhou X, Ai W, Lin J. Yang B, Tu C, Liu Y.* Cytotoxic and antiviral sesquiterpenoid nitrobenzoyl esters from the marine-derived fungus Aspergillus sp. Jcma1F17. MedChemComm 2014, 5, 701-705.

Bai Z, Lin X, Wang Y, Wang J, Zhou X, Yang B, Liu J, Yang X, Wang Y, Liu Y* New phenyl derivatives from endophytic fungus Aspergillus flavipes AIL8 derived of mangrove plant Acanthus ilicifolius. Fitoterapia, 2014, 95, 194-202.

Sun J, Lin X, Zhou X, Wan J, Zhang T, Yang B, Yang X, Tu Z, Liu Y*. Pestalols A-E, New Alkenyl Phenol and Benzaldehyde Derivatives from Endophytic Fungus Pestalotiopsis sp. Acbc2 Isolated from the Chinese Mangrove Plant Aegiceras corniculatum. The Journal of Antibiotics 2014, 67(6), 451-457.

Wang J, Lin X, Qin Z, Liao S, Wan J, Zhang T, Liu J, Fredimoses M, Chen H, Yang Y, Zhou X, Yang X, Tu Z, Liu Y*. Antimicrobial and Antiviral Sesquiterpenoids from Sponge-Associated Fungus, Aspergillus sydowii ZSDS1-F6. The Journal of Antibiotics 2014, 67(8), 581-583.

Liao S, Qin C, Yao P, Li J, Zhou X, Wang J, Huang Z, Liu Y.* A One-Pot Synthesis of Unsaturated, Polysubstituted 3-Aminoazepan-2-ones. Synthesis 2014, 46(5), 621-628.

Yang X, Li S, Li Y, Feng L, Shen Y, Lin S, Tian J, Zeng H, Wang N, Steinmetz A, Liu Y, Zhang W. Chemical constituents of Abies delavayi. Phytochemistry, 2014, 105, 164-170. 

Peng Y, Huang R, Hu J, Zhou X, Yang B, Liu L, Yang X, Liu Y*. Bioactive chemical constituents of the South China Sea starfish Stellaster equestris. Chemistry of Natural Compounds, 2014, 50(1), 184-185.

Huang R, Yan T, Peng Y, Zhou X, Yang X, Liu Y. Diketopiperazines from the marine sponge Axinella sp. Chemistry of Natural Compounds, 2014, 50(1), 191-193.

Wang J, Xu F, Wang Z, Lu X, Wan J, Yang B, Zhou X, Zhang T, Tu Z, Liu Y* A new naphthalene glycoside from the sponge-derived fungus Arthrinium arundinis ZSDS1-F3. Natural Product Research 2014, 28(14), 1070-1074.

Yang B, Dong J, Lin X, Tao H, Zhou Z Liu Y. Xylaolide A, a new lactone from the fungus Xylariaceae sp. DPZ-SY43. Natural Product Research 2014，28(13), 967-970.

Zhou X, Sun J, Ma W, Fang W, Chen Z, Yang B, Liu Y*. A new aromatic amine from fungus Pestalotiopsis vaccinii. Phytochemistry Letters 2014, 7, 35-37.

Zhou X, Sun J, Ma W, Fang W, Chen Z, Yang B, Liu Y*. Bioactivities of six sterols isolated from marine invertebrates. Pharmaceutical Biology 2014, 52(2), 187-190.

Yang B, Tao H, Zhou X, Lin X, Liu Y*. Two new alkaloids from marine sponge Callyspongia sp. Natural Product Research 2013, 27(4-5), 433-437.

Wang L, Yang B, Lin X, Zhou X, Liu Y*. Sesterterpenoids, Natural Product Report 2013, 30, 455-473.

Yang B, Liao S, Lin X, Wang J, Liu J, Zhou X, Yang X, Liu Y*. New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp. Marine Drugs, 2013, 11, 4747-4750.

Strepsesquitriol, a Rearranged Zizaane-Type Sesquiterpenoid from the Deep-Sea-Derived Actinomycete Streptomyces sp. SCSIO 10355. Yang X, Peng K, Liu Z, Zhang G, Li J, Wang N, Steinmetz A, Liu Y. Journal of Natural Product 2013, 76, 2360-2363.

Sun J, Han Z, Zhou X, Yang Y, Lin X, Liu J, Peng Y, Yang X, Liu Y*. Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea, Tetrahedron 2013, 69, 971-880.

Zhou X, Liu J, Yang B, Lin X, Yang X, Liu Y*. Marine Natural Products with Anti-HIV Activities in the Last Decade, Current Medicinal Chemistry 2013, 20(7), 953-973.

Yang X, Zhang G, Ying J, Yang B, Zhou X, Steinmetz A, Liu Y*. Wang N. Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl) methyl)-1H-indole, a new alkaloid from a deep-sea-derivated actinomycete Serinicoccus profundi sp. nov. Marine Drugs 2013, 11, 33-39.

Huang RM, Peng Y, Zhou XF, Yang X, Liu Y*. A new taurine derivative from South China Sea marine sponge Axinella sp. Natural Product Research 2013, 27(17), 1537-1541.

Huang RM, Peng Y, Zhou XF, Fu MQ, Tian S, Liu Y*. A new pyrimidinedione derivative from the gorgonian coral Verrucella umbraculum. Natural Product Research 2013, 27(4-5), 319-322.

Zhou X, Lin X, Guo X, Yang Y, Yang X, Liu Y*. Chemical Constituents of the Sponge Mycale Species from South China Sea, Records of Natural Products 2013, 7, 119-123.

Yang B, Zhou X, Huang H, Yang X, Liu J, Lin X, Li X, Peng Y, Liu Y*. New cembrane diterpenoids from a Hainan soft coral Sinularia sp. Marine Drugs 2012, 10, 2023-2032.

Yang B, Zhou X, Lin X, Liu J, Peng Y, Yang X, Liu Y*. Cembrane diterpenes chemistry and biological properties. Current Organic Chemistry 2012, 16(12), 1512-1539.

Chen J, Lan X, Liu Y*, Jia A. In vitro effects of natural diketopiperazines on release of cytokines and chemokines in J774A.1 macrophages. Bioorganic Medicinal Chemistry Letter 2012, 16, 3177-3180.

Lin X, Zhou X, Wang F, Liu K, Yang B, Yang X, Peng P, Liu L, Ren Z, Liu Y*. A new cytotoxic sesquiterpene quinone produced by Penicillium sp. F00120 isolated from a deep sea sediment sample. Marine Drugs 2012, 10, 106-115.

Kim E, Li J, Dang H, Hong J, Lee C, Kim D, Yoon W, Kim E, Liu Y, Jung J. Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai. Bioorganic & Medicinal Chemistry Letters 2012, 22, 3126–3129.

Li W, Wang L, Zhao D, Liu Y*. Steroidal alkaloids from Veratrum nigrum L. Chemistry of Natural Compounds 2012, 48(5), 919-920.

He WH, Lin L, Xu T, Jung JH, Yin H, Yang B, Liu Y*. A new norsesterterpenoid from the sponge species Sarcotragus. Chemistry of Natural Compounds 2012, 48(2), 208-210.

Peng Y, Xie E, Zheng K, Fredimoses M, Yang Y, Zhou X, Wang Y, Yang B, Lin X, Liu J, Liu Y*. Nutritional and Chemical Composition and Antiviral Activity of Cultivated Seaweed Sargassum naozhouense Tseng et Lu. Marine Drugs 2013, 11, 20-32.

Huang R, Wang B, Liu Y*. Briarane-type diterpenoids from the gorgonian coral Verrucella umbraculum. Chemistry of Natural Compounds 2012, 48(3), 516-517.

Yang B, Hu J, Lei H, Chen XC, Zhou XF, Liu Y*. Chemical constituents of marine sponge Callyspongia sp. from the South China Sea. Chemistry of Natural Compounds 2012, 48(2), 350-351.

Liao X, Tang L, Liang Y, Jian S, Xu S, Liu Y*. New pentahydroxylated steroids from the South China Sea gorgonian Subergorgia suberosa Chemistry & Biodiversity 2012, 9, 370-375.

Liu Y*. Renaissance of marine natural product drug discovery and development.  Journal of Marine Science Research & Development 2012, 2, 1000e106.

Sun J, Huang H, Chai X, Yang X, Meng L, Huang C, Zhou X, Yang B, Hu J, Chen X, Lei H, Wang L, Liu Y*. Dichotellides A-E, five new iodine-containing briarane type diterpenoids from Dichotella gemmacea. Tetrahedron 2011, 67, 1245-1250.

Wang L, Zhao D, Di L, Xu T, Lin X, Yang B, Zhou X, Yang X, Liu Y*. The analgesic and anti-rheumatic effects of Thladiantha dubia fruit crude polysaccharide fraction in mice and rats. Journal of Ethnopharmacology 2011, 137, 1381-1387.

Zhou X, Lu Y, Lin X, Yang Y, Yang X, Liu Y. Brominated aliphatic hydrocarbons and sterols from the sponge Xestospongia testudinaria with their bioactivities Chemistry and Physics of lipids 2011, 164, 703-706.

Yang X, Li Y, Li S, Shen Y, Tian J, Zhu Z, Feng L, Wu, L, Lin, S, Wang, N, Liu Y, Zhang W. Mono- and sesquiterpenoids, flavonoids, lignans, and other miscellaneous compounds of Abies georgei. Planta Medica 2011, 77(7), 742-748.

Wang L, Zhao D, Di L, Cheng D, Zhou X, Yang X, Liu Y*. The anti-hyperplasia of mammary gland effect of Thladiantha dubia root ethanol extract in rats reduced by estrogen and progestogen. Journal of Ethnopharmacology 2011, 134, 136-140.

Yang X, Dong G, Zhou X, Chai X, Li Y, Yang B, Zhang W, Liu Y*. Isolation and structural characterisation of five new and 14 known metabolites from the commercial starfish Archaster typicus Food Chemistry 2011, 124, 1634-1638.

Liu Y*, Yan H, Wen K, Zhang J, Xu T, Wang L, Zhou X, Yang X. Identification of epidioxysterol from South China Sea urchin Tripneustes gratilla Linnaeus and its cytotoxic activity. Journal of Food Biochemistry 2011, 35, 932-938.

Hu J, Yang B, Lin X, Zhou X, Yang X, Long L, Liu Y*. Chemical and Biological Studies of Soft Corals Nephtheidae Family. Chemistry & Biodiversity 2011, 8, 1011-1032.

Dong G, Yang X, Zhou X. Liu Y*. Chemical constituents and bioactivities of starfish. Chemistry & Biodiversity 2011, 8(5), 740-791.

Huang R, Zhou X, Peng Y, Yang X, Xu T, Liu Y*. Nucleosides from the marine sponge Callyspongia sp. Chemistry of Natural Compounds 2011, 46, 1010-1011.

Liu Y*, Jung J, Xu T, Long LJ, Lin XP, Yin H., Yang B, Zhou XF, Yang XW. New cyclitol derivative from a sponge Sarcotragus species. Natural Products Research 2011, 25(6), 648-652.

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学科组建设

责任研究员：刘永宏

研究员：周雪峰

副研究员：王俊锋、杨斌、廖升荣（项目）、林秀萍（项目）

博士后：徐亮

科研助理：许华炎

博士研究生：陈伟豪（2017直博生）、李坤龙（2018）、龙洁怡（2019）

硕士研究生：陈春梅（2018）、宋莹莹（2019）

已培养博士研究生10名；硕士研究生12名