实验室研究员
王发左研究员
副标题：
王发左博士 研究员
中国科学院南海海洋研究所仪器设备公共服务中心主任
（海洋生物活性物质及其化学生态学学科组 E-mail：wangfazuo@scsio.ac.cn)
研究兴趣
海洋特殊环境微生物资源、化学及功能研究。
代表性成果简介
主要从事海洋特殊环境微生物资源、化学及功能方面的研究工作，取得了一系列创新性研究成果，包括分离鉴定150多个新化合物，发现具有生物活性的单体化合物60多个。近年先后主持国家基金项目2项，主持广东省-中科院全面战略合作项目（第二负责人）和国家863子课题各1项，参加973计划项目、国家基金重点项目、广东海洋经济创新发展区域示范等多项课题的研究；在Org. Lett.、Org. Chem. Front.、J. Org. Chem.等期刊发表学术论文65篇（含SCI论文50篇），参与出版专著1册，获授权发明专利3项；获广东省等科技成果奖2项；指导和协助指导研究生9名。J Agric Food Chem、Molecules、Nat Prod Res等杂志审稿人。
工作经历
2023.03-至今，中国科学院南海海洋所，仪器设备公共服务中心主任
2018.07-2023.03，中国科学院南海海洋所，人事教育处处长
2017.12-至今，中国科学院南海海洋所，研究员
2012.07-2018.07，中国科学院南海海洋所，人事教育处副处长
2010.12-2017.12，中国科学院南海海洋所，副研究员
2008.07-2010.12，中国科学院南海海洋所，助理研究员
2003.08-2005.07，中国科学院海洋所，研究助理
教育经历
2005.09-2008.06，中国海洋大学，药物化学，博士
1996.09-2003.07，安徽农业大学，农学学士、硕士
获奖及荣誉
1. 2011年度广东省科技发明一等奖（排名第十一）
2. 2007年度海洋创新成果二等奖（排名第十）
代表性成果
论文发表（第一或通讯作者）
1. Zeng, Q.; Chen, Y.; Wang, J.; Shi, X.; Che, Y.; Chen, X.; Zhong, W.; Zhang, W.; Wei, X.; Wang, F.*; Zhang, S.* Diverse Secondary Metabolites from the Coral-Derived Fungus Aspergillus hiratsukae SCSIO 5Bn1003. Mar Drugs 2022, 20 (2).
2. Chen, X. Y.; Zeng, Q.; Chen, Y. C.; Zhong, W. M.; Xiang, Y.; Wang, J. F.; Shi, X. F.; Zhang, W. M.; Zhang, S.; Wang, F. Z.*Chevalones H-M: Six New alpha-Pyrone Meroterpenoids from the Gorgonian Coral-Derived Fungus Aspergillus hiratsukae SCSIO 7S2001. Mar Drugs 2022, 20 (1).
3. Zhong, W. M.; Wei, X. Y.; Chen, Y. C.; Zeng, Q.; Wang, J. F.; Shi, X. F.; Tian, X. P.; Zhang, W. M.; Wang, F. Z.*; Zhang, S.* Structurally Diverse Polycyclic Salicylaldehyde Derivative Enantiomers from a Marine-Derived Fungus Eurotium sp. SCSIO F452. Mar Drugs 2021, 19 (10).
4. Zhong, W. M.; Chen, Y. C.; Wei, X. Y.; Wang, J. F.; Zeng, Q.; Tian, X. P.; Zhang, W. M.; Wang, F. Z.*; Zhang, S.* Euroticins C-E, three pairs of polycyclic salicylaldehyde derivative enantiomers from a marine-derived fungus Eurotium sp. SCSIO F452. Organic Chemistry Frontiers 2021, 8 (7), 1466-1473.
5. Zhong, W.; Chen, Y.; Wei, X.; Wang, J.; Zhang, W.; Wang, F.*; Zhang, S.* Salicylaldehyde derivatives from a marine-derived fungus Eurotium sp. SCSIO F452. J Antibiot (Tokyo) 2021, 74 (4), 273-279.
6. Xiang, Y.; Zeng, Q.; Mai, Z. M.; Chen, Y. C.; Shi, X. F.; Chen, X. Y.; Zhong, W. M.; Wei, X. Y.; Zhang, W. M.; Zhang, S.; Wang, F.*Asperorydines N-P, three new cyclopiazonic acid alkaloids from the marine-derived fungus Aspergillus flavus SCSIO F025. Fitoterapia 2021, 150, 104839.
7. Zhong, W.; Chen, Y.; Mai, Z.; Wei, X.; Wang, J.; Zeng, Q.; Chen, X.; Tian, X.; Zhang, W.; Wang, F.*; Zhang, S.* Euroticins A and B, Two Pairs of Highly Constructed Salicylaldehyde Derivative Enantiomers from a Marine-Derived Fungus Eurotium sp. SCSIO F452. J. Org. Chem. 2020, 85 (19), 12754-12759.
8. Zeng, Q.; Zhong, W. M.; Chen, Y. C.; Xiang, Y.; Chen, X. Y.; Tian, X. P.; Zhang, W. M.; Zhang, S.; Wang, F. Z.* A new butenolide derivative from the deep-sea fungus Aspergillus terreus SCSIO FZQ028. Nat. Prod. Res. 2020, 34 (14), 1984-1991.
9. Zhong, W.-M.; Wang, J.-F.; Wei, X.-Y.; Zeng, Q.; Chen, X.-Y.; Xiang, Y.; Tian, X.-P.; Zhang, S.; Long, L.-J.*; Wang, F.-Z.*, (+)- and (−)-Eurotone A: A pair of enantiomeric polyketide dimers from a marine-derived fungus Eurotium sp. SCSIO F452. Tetrahedron Lett. 2019,60 (24), 1600-1603.
10. Zhong, W. M.; Wang, J. F.; Wei, X. Y.; Fu, T. D.; Chen, Y. C.; Zeng, Q.; Huang, Z. H.; Huang, X. N.; Zhang, W. M.; Zhang, S.; Long, L. J.*; Wang, F. Z.*, Three Pairs of New Spirocyclic Alkaloid Enantiomers From the Marine-Derived Fungus Eurotium sp. SCSIO F452. Frontiers in Chemistry 2019, 7, 350.
11. Zeng, Q.; Zhong, W. M.; Chen, Y. C.; Xiang, Y.; Chen, X. Y.; Tian, X. P.; Zhang, W. M.; Zhang, S.; Wang, F. Z.*, A new butenolide derivative from the deep-sea fungus Aspergillus terreus SCSIO FZQ028. Nat Prod Res 2019, 1-8.
12. Zhong, W.; Wang, J.; Wei, X.; Chen, Y.; Fu, T.; Xiang, Y.; Huang, X.; Tian, X.; Xiao, Z.; Zhang, W.; Zhang, S.; Long, L*.; Wang, F.*, Variecolortins A-C, Three Pairs of Spirocyclic Diketopiperazine Enantiomers from the Marine-Derived Fungus Eurotium sp. SCSIO F452. Org. Lett.2018, 20 (15), 4593-4596.
13. Zhong, W. M.; Wang, J. F.; Shi, X. F.; Wei, X. Y.; Chen, Y. C.; Zeng, Q.; Xiang, Y.; Chen, X. Y.; Tian, X. P.; Xiao, Z. H.; Zhang, W. M.; Wang, F. Z.*; Zhang, S.*, Eurotiumins A-E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp SCSIO F452. Marine Drugs2018, 16 (4), 136.
14. Wang, F. Z.; Li R.; Long L.J.; Tian X.P.; Xiao Z.H.; Zhang S.; Yin H., A three-phase solvent system in high-speed counter-current chromatographic for the separation and purification of bioactive constituents from Acanthus ilicifolius. Chromatographia 2015, 78(21), 1401-1407
15. Wang, F. Z.; Huang，Z; Shi, X. F.; Chen, Y. C.; Zhang, W. M.; Tian, X. P.; Li, j.; Zhang, S., Cytotoxic indole diketopiperazines from the deep sea-derived fungus Acrostalagmusluteoalbus SCSIO F457, Bioorg. Med. Chem. Lett. 2012, 22 (23), 7265-7267.
16. Huang, H. B.; Wang, F. Z. （并列第一）; Luo, M. H.; Chen, Y. H.; Song, Y. X.; Wang, B.; Ma, J. Y.; Zhang, W. M.; Zhang, C. S.; Zhang, S.; Ju, J. H., Halogenated Anthraquinones from the Marine-derived Fungus Aspergillus sp. SCSIO F063. J. Nat. Prod. 2012, 75 (7), 1346-1352.
17. Wang, F. Z.; Li, D. H.; Zhu, T. J.; Zhang, M.; Gu, Q. Q., Pseurotin A(1) and A(2), two new 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-diones from the holothurian-derived fungus Aspergillus fumigatus WFZ-25. Can. J. Chem., 2011, 89(1): 72-76.
18. Wang, F. Z.; Tian, X. P.; Huang, C. G.; Li, Q. X.; Zhang, S., Marinactinones A-C, new gamma-pyrones from marine actinomycete Marinactinosporathermotolerans SCSIO 00606. J. Antibiot. 2011, 64 (2), 189-192.
19. Wang, F. Z.; Wei, H. J.; Zhu, T. J.; Li, D. H.; Lin, Z. J.; Gu, Q. Q., Three New Cytochalasins from the Marine-Derived Fungus Spicaria elegans KLA03 by Supplementing the Cultures with L- and D-Tryptophan. Chem Biodivers 2011, 8 (5), 887-94.
20. Wang, F. Z.; Zhu, T. J.; Zhang, M.; Lin, A. Q.; Zhu, W. M.; Gu, Q. Q., Structural determination of aspericins A-C, new furan and pyran derivates from the marine-derived fungus Rhizopus sp 2-PDA-61, by 1D and 2D NMR spectroscopy. Magn. Reson. Chem. 2010, 48 (2), 155-158.
21. Wang, F. Z.; Fang, Y. C.; Zhu, T. J.; Zhang, M.; Lin, A. Q.; Gu, Q. Q.; Zhu, W. M., Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus. Tetrahedron 2008, 64(34), 7986-7991.
22. Wang, F.; Fang, Y.; Zhang, M.; Lin, A.; Zhu, A.; Gu, Q.; Zhu, W., Six new ergosterols from the marine-derived fungus Rhizopus sp. Steroids 2008, 73 (1), 19-26.
23. Wang, F. Z.; Zhang, M.; Sun, W.; Gu, Q. Q.; Zhu, W. M., 5a-hydroxy-9-methoxy-11-(3- methyl-2-butenyl)-12-(2-methyl-1-propenyl)-2, 3,11,12-tetrahydro-1H,5H-pyrrolo 1 '',2 '': 4 ',5 ' pyrazino 1 ',2 ': 1,6 pyrido 3,4-b indole-5,6,14(5aH, 14aH)-trione. Acta Crystallographica Section E-Structure Reports Online 2007,63, O1859-O1860.
授权专利（第一发明人）
1. 王发左, 张偲, 黄智, 田新朋, 李洁. 含硫双吲哚二酮哌嗪类化合物及其在制备抗肿瘤药物中的应用. 公开号CN102911188B（2015.01.07），专利号：ZL201210301553.1
培养研究生情况
指导和协助指导博士生4名，硕士生5名
电话：020-89023101 传真：86-20-84451672 Email：liujuan@scsio.ac.cn