研究领域

海洋来源微生物天然产物的发现与生物合成研究。

（1）海洋新药源分子的发现：采用随机筛选和基因组挖掘相结合的方法发现海洋微生物来源新药源分子，并提高其产量。

（2）海洋新功能酶的发现：揭示海洋微生物合成天然产物的新机制，发掘具有绿色催化功能的酶。

代表性工作简介

主要从事海洋微生物来源新药源分子和新功能酶的发现研究，代表性工作包括：1）分离鉴定天然产物200多个，包括新化合物80多个；2）鉴定了厦霉素、TPMs、CYAs、nenestatins和kongjuemycins等多类化合物的生物合成基因簇，阐明了十余种生物合成酶的功能。发表SC1论文近70篇，包括第一/通讯作者论文20篇，其中部分发表在J Am Chem Soc、Angew Chem Int Ed、Chem Sci和Org Lett等期刊上；参与编写专著1部，授权发明专利14项。主持项目6项，包括国家自然科学基金面上/青年基金项目、广州市科技计划项目“珠江新星”专项和海南省自然科学基金面上项目。

工作经历

2017.01-至今：中国科学院南海海洋研究所，副研究员，项目研究员

2013.05-08和2014.09-11：德国马堡大学，短期研修生

2013.07-2016.12：中国科学院南海海洋研究所，助理研究员

2008.07-2010.07：广东省微生物研究所，研究助理

教育背景

2010.07-2013.07：中国科学院大学（南海海洋研究所）海洋生物学，博士

2005.09-2008.07：中山大学药学院，生药学，硕士

2001.09-2005.07：湖南中医药大学药学院，中药学，学士

获奖及荣誉

1. 中国科学院院长优秀奖（2013）

2. 广州市“珠江科技新星”（2016）

3. 中国科学院南海海洋研究所“南海新星”（2018）

代表性成果

1、已发表文章66篇（第一作者或通讯作者20篇），授权专利14件。

^# (第一作者)，^* (通讯作者)

1. Zhuangjie Fang, Qingbo Zhang^,* Weiliang Xiong, Lili Sun, Bin Tan, Mengyi Zhu, Liang Ma, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of Tetronate-containing Kongjuemycins from a Coral-associated Actinomycete and Elucidation of Their Biosynthetic Origin. Organic Letters, 2023, 25 (34): 6346-6351.

2. Bin Tan,^# Liping Zhang,^# Qingbo Zhang,^# Siqiang Chen, Weiliang Xiong, Yiguang Zhu^*, Changsheng Zhang^*. A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angewandte Chemie International Edition, 2023, 62 (27): e202302043.

3. Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang,^* Qingbo Zhang^*. Aromatic polyketides from the mangrove-derived Streptomyces sp. SCSIO 40069. Journal of Natural Products, 2023, 86 (4): 979-985.

4. Ziqian Cheng,^# Qingbo Zhang,^# Jing Peng,^# Xiaoyang Zhao, Liang Ma, Changsheng Zhang^*, Yiguang Zhu^*. Genomics-Driven discovery of benzoxazole alkaloids from the marine-derived Micromonospora sp. SCSIO 07395. Molecules, 2023, 28 (2): 821.

5. Bin Tan,^# Qingbo Zhang,^# Ji Xiao, Chengshan Yuan, Yuchan Chen, Siqiang Chen, Weimin Zhang, Yiguang Zhu^*, and Changsheng Zhang^*. Characterization of the P450 monooxygenase LobP1 as C-32 hydroxylase in lobophorin biosynthesis. Chinese Journal of Chemistry, 2023, (12): 1478–1484.

6. Bin Tan, Qingbo Zhang,^* Jieyi Li, Yiguang Zhu, Liping Zhang, Wenjun Zhang, Haibo Zhang, Yang Chen, Changsheng Zhang^*. Totopotensamide congeners from a halogenase-inactivated mutant. Journal of Natural Products, 2023, 86 (1): 76–84.

7. Bin Tan, Qingbo Zhang,^* Liping Zhang, Yiguang Zhu, Changsheng Zhang^*. Functional characterization of the sulfotransferase TotS in totopotensamide biosynthesis. Tetrahedron, 2022, 127: 133103.

8. Zhuangjie Fang, Qingbo Zhang,^* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang Yiguang Zhu, Changsheng Zhang^*. Antifungal macrolides kongjuemycins from coral-associated rare actinomycete Pseudonocardia kongjuensis SCSIO 11457. Organic Letters, 2022, 24 (19): 3482–3487.

9. Xiaodong Jiang,^# Zhuangjie Fang,^# Qingbo Zhang,^* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang*. Discovery of a new asymmetric dimer nenestatin B and implications of dimerizing enzyme in a deep sea Actinomycete. Organic & Biomolecular Chemistry, 2021, 19 (19): 4243-4247.

10. Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang^*, and Changsheng Zhang^*. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457. Natural Product Research, 2021, 35(2):188-194.

11. Yiguang Zhu,^# Qingbo Zhang,^# Chunyan Fang, Yingli Zhang, Liang Ma, Zhiwen Liu, Shilan Zhai, Jing Peng, Liping Zhang, Weiming Zhu,^* and Changsheng Zhang^*. Refactoring the concise biosynthetic pathway of cyanogramide unveils spirooxindole formation catalyzed by a P450 enzyme. Angewandte Chemie International Edition, 2020, 59 (33): 14065-14069.

12 Zhuangjie Fang,^# Xiaodong Jiang,^# Qingbo Zhang,^* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang^*. S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derived Micromonospora echinospora SCSIO 04089. Journal of Natural Products, 2020, 83 (10): 3122–3130.

13. Bin Tan,^# Qingbo Zhang,^# Yiguang Zhu, Hongbo Jin, Liping Zhang, Siqiang Chen, and Changsheng Zhang*. Deciphering biosynthetic enzymes leading to 4-chloro-6-methyl-5,7-dihydroxyphenylglycine, a non-proteinogenic amino acid in totopotensamides. ACS Chemical Biology, 2020, 15 (3): 766-773.

14. Bin Tan,^# Siqiang Chen,^# Qingbo Zhang,^* Yuchan Chen, Yiguang Zhu, Imran Khan, Weimin Zhang and Changsheng Zhang^*. Heterologous expression leads to discovery of diversified lobophorin analogues and a flexible glycosyltransferase. Organic Letters, 2020, 22 (3): 1062-1066.

15. Ruidong Chen,^# Qingbo Zhang,^# Bin Tan, Liujuan Zheng, Huixian Li, Yiguang Zhu, Changsheng Zhang^*. Genome mining and activation of a silent PKS/NRPS gene cluster direct the production of totopotensamides. Organic Letters, 2017, 19(20): 5697-5700.

16. Qingbo Zhang,^# Huixian Li,^# Lu Yu, Yu Sun, Yiguang Zhu, Hanning Zhu, Liping Zhang, ShuMing Li, Yuemao Shen, Changlin Tian, Ang Li, Hung-wen Liu,^* and Changsheng Zhang^*. Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification. Chemical Science, 2017, 8(7): 5067-5077.

17. Qingbo Zhang, Sumei Li, Yuchan Chen, Xinpeng Tian, Haibo Zhang, Guangtao Zhang, Yiguang Zhu, Si Zhang, Weimin Zhang & Changsheng Zhang^*. New diketopiperazine derivatives from a deep-sea-derived Nocardiopsis alba SCSIO 03039. The Journal of Antibiotics, 2013, 66 (1): 31-36.

18. Qingbo Zhang,^# Huixian Li,^# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Wenjun Zhang, Rong Shi, and Changsheng Zhang^*. Carboxyl formation from methyl via triple hydroxylations by XiaM in xiamycin A biosynthesis. Organic Letters, 2012, 14 (24): 6142–6145.

19. Qingbo Zhang, Attila Mándi, Sumei Li, Yuchan Chen, Wenjun Zhang, Xinpeng Tian, Haibo Zhang, Huixian Li, Weimin Zhang, Si Zhang, Jianhua Ju, Tibor Kurtán,^* Changsheng Zhang^*. N–N-coupled indolosesquiterpene atropo-diastereomers from a marine-derived actinomycete. European Journal of Organic Chemistry, 2012, 2012 (27): 5256-5262.

20. Huixian Li,^# Qingbo Zhang,^# Sumei Li, Yiguang Zhu, Guangtao Zhang, Haibo Zhang, Xinpeng Tian, Si Zhang, Jianhua Ju, and Changsheng Zhang^*. Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis. Journal of the American Chemical Society, 2012, 134 (21): 8996-9005.

培养研究生情况

在读研究生2名

2023级硕士：杨紫怡

2024级硕士：陈玄皓