张偲院士

（海洋生物活性物质及其化学生态学学科组责任研究员）

研究兴趣与领域

主要从事.海洋生物活性物质及其化学生态学和海洋微生物多样性的研究。

代表性工作简介

担任国家重点研发计划项目“南海典型海岛生态建设与生态物联网监测技术研究与示范”首席科学家，聚焦“南海生态安全及其可持续发展”等核心科技问题，牵头负责南海生态物联网建设示范工程。围绕“热带海洋微生物多样性的时空分布特征及其功能”关键生态工程科技问题，开展微生物多样性的观测、认知和利用研究，发展热带海洋生态工程理论，发明微生物促生态修复等关键技术，促进热带海洋生态保护和生物资源利用的工程化，积极推进我国海洋战略性新兴产业发展与海洋生态建设。

学习经历

1981.09-1985.07：中国海洋大学，理学学士

1985.09-1988.07：中国科学院南海海洋研究所，理学硕士

1995.09-1998.07：中国科学院南海海洋研究所，理学博士

工作经历

1998.08-至今：中国科学院南海海洋研究所，责任研究员

2006.10-2009.06：中国科学院南海海洋研究所，副所长(主持工作)

2009.07-至今：中国科学院南海海洋研究所，所长

2013.12-至今：中国工程院院士

获奖与荣誉

1. 国家技术发明奖二等奖（第一，2004）

2. 获国务院特殊津贴（2004）

3. 国家科技进步奖二等奖（第一，2007）

4. “973”项目首席科学家（2010）

5. 何梁何利基金科技创新奖（2011）

6. 中国工程院院士（2013）

7. 第十五届中国专利优秀奖（第一，2013）

8. 中科院特聘核心骨干研究员（2015）

9. 首届全国创新争先奖（2017）

学术兼职

1. 中国海洋学会热带海洋分会主任委员（2012-2022）

2. 中国海洋学会常务理事（2010-2020）

3. 中国海洋与湖沼学会常务理事（2007-2022）

4. 《热带海洋学报》主编（2014-至今）

5. 《中国海洋药物》编委（2013-至今）

代表性学术成果

论文发表

35. ZHONG Weimao, WANG Junfeng, SHI Xuefeng, WEI Xiaoyi, CHEN Yuchan, ZENG Qi, XIANG Yao, CHEN Xiayu, TIAN Xinpeng, XIAO Zhihui, ZHANG Weimin, WANG Fazuo*, ZHANG Si*. Eurotiumins A–E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp. SCSIO F452. Marine Drugs. 2018,16,4,1-10

34. ZHONG Weimao, WANG Junfeng, SHI Xuefeng, WEI Xiaoyi, CHEN Yuchan, ZENG Qi, XIANG Yao, CHEN Xiayu, TIAN Xinpeng, XIAO Zhihui, ZHANG Weimin, WANG Fazuo*, ZHANG Si*. Eurotiumins A–E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp. SCSIO F452. Marine Drugs. 2018,16,4,1-10

33. Jie Li*, Weiqi kuang, Lijuan Long, Si Zhang. Production of quorum sensing signals by bacteria in the coral mucus layer. Coral Reefs, 2017, 36: 1235-1241.

32. Yin, H*, Wei, Y, Chen, R, Zhang, S*, Long, L, Yin, H, Tian, X, He, W. Identifying Natural syNergist from Pongamia pinnata Using High-Speed Counter-Current Chromatography Combined with Isobolographic Analysis. Molecules 2017, 22 (3), 397.

31. Jie Li*, Farooq Azam, Si Zhang. Outer membrane vesicles containing signalling molecules and active hydrolytic enzymes released by a coral pathogen Vibrio shilonii AK1. Environmental Microbiology, 2016, 18: 3850-3866.

30. Zhimao Mai, Hongfei Su, Si Zhang*. Characterization of a metagenome-derived beta-glucosidase and its application in conversion of polydatin to resveratrol, Catalysts, 2016.3.01, 6(3).

29. Lizhen Li#, Jian Yang#, Jie Li, Lijuan Long, Yunzhu Xiao, Xinpeng Tian, Fazuo Wang, Si Zhang*. Role of two amino acid residues’ insertion on thermal stability of thermophilic a-amylase AMY121 from a deep sea bacterium Bacillus sp. SCSIO 15121. Bioprocess and Biosystems Engineering. 2015,38(5):871-879

28. Jian Yang#, Jie Li, Yunfeng Hu, Lizhen Li, Lijuan Long, Fazuo Wang, Si Zhang*. Characterization of a thermophilic hemoglobin-degrading protease from Streptomyces rutgersensis SCSIO 11720 and its application in antibacterial peptides production. Bioprocess and Biosystems Engineering. 2015,20(1):79-90

27. Jie Li, Qi Chen, Li-Juan Long, Jun-De Dong, Jian Yang, Si Zhang*. Bacterial dynamics within the mucus, tissue and skeleton of the coral Porites lutea during different seasons. Scientific Reports. 2014,4:7320  

26. Li, L.; Yang, J.; Li, J.; Long, L.; Xiao, Y.; Tian, X.; Wang, F.; Zhang, S*. Role of two amino acid residues’ insertion on thermal stability of thermophilic α-amylase AMY121 from a deep sea bacterium Bacillus sp. SCSIO 15121. Bioprocess and Biosystems Engineering. 2014,1-9  

25. Jie Li, Jun-De Dong, Jian Yang, Xiong-Ming Luo, Si Zhang*. Detection of polyketide synthase and nonribosomal peptide synthetase biosynthetic genes from antimicrobial coral-associated actinomycetes. Antonie van Leeuwenhoek. 2014,106:623-635  

24. Xiongming Luo*, Yongzhong Huang, Si Zhang*, Hao Yin, Chuanrong Li, Qingxin Li. Five new phenethyl cinnamides from the mangrove associates Micromelum falcatum. Biochemical Systematics and Ecology. 2014,(56):191-195  

23. Jian Yang, Jie Li, Zhimao Mai, Xinpeng Tian, Si Zhang*. Purification, characterization, and gene cloning of a cold-adapted thermolysin-like protease from Halobacillus sp SCSIO 20089. Journal of Bioscience and Bioengineering. 2013,115(6):628-632  

22. YuJuan Liu, LiJuan Long, Xiaofang Huang, Zhiing You, Fazuo Wang, Jie Li, Changjin Kim, Xinpeng Tian, Si Zhang*. Bacillus oceani sp. nov., a new slightly halophilic bacterium, isolated from a deep sea sediment environment. Antonie van Leeuwenhoek. 2013,104(5):829-836  

21. Zhiqing You, Jie Li, Sheng Qin Xinpeng Tian, Fazuo Wang, Si Zhang*. Bacillus abyssalis sp. nov., isolated from a sediment of the South China Sea. Antonie van Leeuwenhoek. 2013,103(5):963-969  

20. Xinpeng Tian, Lijuan Long, Sumei Li, Jing Zhang, Ying Xu, Jie He, Jie Li,1 Fazuo Wang, Wenjun Li, ChangSheng Zhang, Si Zhang*. Pseudonocardia antitumoralis sp. nov., a deoxynyboquinone-producing actinom ycete isolated from a deep-sea sediment. International journal of systematic and evolutionary microbiology. 2013,63:893-899  

19. Ying Xu, Xinpeng Tian(并列第一), YuJuan Liu,1 Jie Li, Changjin Kim,Hao Yin, Wenjun Li*, and Si Zhang*. Sinomicrobium oceani gen. nov., sp. nov., a member of the family Flavoba cteriaceae isolated frommarinesediment. International journal of systematic and evolutionary microbiology. 2013,63:1045-1050  

18. Zhiqing You, Jie Li, Sheng Qin, Xin-Peng Tian, Fazuo Wang, Si Zhang*. Georgenia sediminis sp. nov., a moderate thermophilic actinobacterium isolated from sediment of south china sea. International journal of systematic and evolutionary microbiology 2013,63:4243-4247  

17. Jie Li, Sheng Qin, Zhiqing You, Lijuan Long, Xinpeng Tian, Fazuo Wang, Si Zhang*. Melghirimyces profundicolus sp. nov., isolated from a deep sea sedimentprofundicolus sp. nov., isolated from a deep sea sediment. International journal of systematic and evolutionary microbiology 2013,63(12):4552-4556  

16. Hao Yin*, Si Zhang*,  Lijuan Long, Hang Yin, Xinpeng Tian,  Xiongming Luo, Haihan Nan, Sha He. The separation of flavonoids from Pongamia pinnata using combination columns in high-speed counter-current chromatography with a three-phase solvent system. Journal of Chromatography A. 2013,1315(0):80-85  

15. Li, J., Long, L.-J., Yang, L.-L., Xu, Y., Wang, F.-Z., Li, Q.-X., Zhang, S*, Li, W.-J*. Janibacter alkaliphilus sp. nov., isolated from coral Anthogorgia sp. Antonie Van Leeuwenhoek International Journal of General and Molecular Microbiology. 2012, 102, (1), 157-162  

14. Tian, X.-P., Xu, Y., Zhang, J., Li, J., Chen, Z., Kim, C.-J., Li, W.-J., Zhang, C.-S., Zhang, S.* Streptomyces oceani sp nov., a new obligate marine actinomycete isolated from a deep-sea sample of seep authigenic carbonate nodule in South China Sea. Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology. 2012, 102, (2), 335-343.  

13. Tian, X.-P., Long, L.-J., Wang, F.-Z., Xu, Y., Li, J., Zhang, J., Zhang, C.-S., Zhang, S.*, Li, W.-J.* Streptomyces nanhaiensis sp nov., a marine streptomycete isolated from a deep-sea sediment. International Journal of Systematic and Evolutionary Microbiology. 2012, 62, 864-868  

12. Luo, X., He, W., Yin, H., Li, Q., Liu, Q., Huang, Y., Zhang, S.,* Two New Coumarins from Micromelum falcatum with Cytotoxicity and Brine Shrimp Larvae Toxicity. Molecules. 2012, 17, (6), 6944-6952  

11. Xiao, Z.-H., Wang, F.-Z., Sun, A.-J., Li, C.-R., Huang, C.-G., Zhang, S.* A New Triterpenoid Saponin from Abrus precatorius Linn. Molecules. 2012, 17, (1), 295-302  

10. Li, J., Yang, J., Zhu, W.-Y., He, J., Tian, X.-P., Xie, Q., Zhang, S.*, Li, W.-J.* Nocardiopsis coralliicola sp. nov., isolated from the gorgonian coral, Menella praelonga. International journal of systematic and evolutionary microbiology. 2012, 62, (Pt 7), 1653-8  

9.  Li, J., Zhang, G.-T., Yang, J., Tian, X.-P., Wang, F.-Z., Zhang, C. S., Zhang, S.*, Li, W.-J.*. Marininema mesophilum gen. nov., sp nov., a thermoactinomycete isolated from deep sea sediment, and emended description of the family Thermoactinomycetaceae. International journal of systematic and evolutionary microbiology. 2012, 62, 1383-1388  

8.  Jie Li, Jian Yang, Wen-Yong Zhu, Jie He, Xin-Peng Tian, Qiong Xie, Si Zhang*, Wen-Jun Li. Nocardiopsis coralliicola sp. nov., isolated from the gorgonian coral, Menella praelonga. International journal of systematic and evolutionary microbiology. 2012, 62, 2517-2521.  

7.  Zhihui Xiao, Fazuo Wang, Hao Yin, Aijun Sun,Chuanrong Li, Qingxin Li,and Si Zhang*. A NEW FLAVANONE FROM Abrus precatorius. Chemistry of Natural Compounds. 2012, 48(4): 565-567  

6.  Wang, F.; Tian, X.; Huang, C.; Li, Q.; Zhang, S.*，Marinactinones A-C, new gamma-pyrones from marine actinomycete Marinactinospora thermotolerans SCSIO 00606.，J. Antibiot.，2011, 64 (2):189-92.  

5.  Si Zhang*，Lijuan Long，Effects of glycopeptides on development, growth and non-specific immunity of pearl oyster Pinctada fucata (Gould)，2010，Aquaculture Nutrition, 16: 520-527

4.  Xin-Peng Tian, Shu-Kun Tang, Jun-Ded Dong, Yu-Qin Zhang, Li-Hua Xu, Si Zhang* and Wen-Jun Li*. Marinactinospora thermotolerans gen. nov., sp. nov., a novel marine actinomycete isolated from a sediment in the northern South China Sea. Int J Syst Evol Microbiol. 2009, 59: 948 - 952.  

3.  Xin-Peng Tian, Yu-Qin Zhang, Qing-Xin Li, Xiao-Yang Zhi,Shu-Kun Tang, Si Zhang* and Wen-Jun Li*. Streptomyces nanshensis sp. nov., isolated from Nansha Islands of South China Sea. Int J Syst Evol Microbiol. 2009,59:745-749.  

2.  Xin-Peng Tian, Xiao-Yang Zhi, Yun-Qi Qiu, Yu-Qin Zhang, Shu-Kun Tang, Li-Hua Xu, Si Zhang* and Wen-Jun Li.Sciscionella marina gen. nov., sp. nov., a novel marine actinomycete isolated from a sediment in the northern south China Sea. Int J Syst Evol Microbiol. 2009,59:222-228.  

1. Hao Yin, Si. Zhang*, et al. Preparative isolation and purification of two benzoxazinoid glucosides from Acanthus ilicifolius L. by high-speed counter-current chromatography. Journal of Chromatography A. 2008,1205(1-2):177-18.   

撰写专著

1. 《三亚湾生态环境与生物资源》(2007)，主编：黄良民、张偲，科学出版社

2. 《中国海洋微生物多样性》（2013） ，主编：张偲，出版社: 科学出版社

授权专利

1. 一种海洋放线菌发酵提取物及其组合物和在抗生物污损的应用，ZL200810220427.7  张偲，罗雄明，尹 浩，漆淑华，田新朋

2. 一种鱿鱼内脏提取的小肽及其制备方法、组合物和作为海洋水产饲料蛋白源的用途，ZL201010272510.6  张偲，罗雄明，尹浩，齐振雄，李庆欣

3. 一种海洋来源Bacillus barbaricus SCSIO 02429以及用它制备鱿鱼小肽的方法，香港专利授权：CN101974460B；日本专利授权号：特願2012-535620  张偲，尹浩，罗雄明，齐振雄，田新朋

4. 一种海洋细菌适冷蛋白酶及其编码基因和应用，ZL201210180260.2  张偲，杨键，李洁，麦志茂，田新朋，尹浩

5. 一种假诺卡氏菌及利用其制备deoxynyboquinone的方法，ZL201110231994.4  张偲，张长生，田新朋，李苏梅，张文军，张海波，张光涛，尹浩，鞠建华

6. 一种新颖的糖苷水解酶家族44的纤维素酶及其编码基因和应用，ZL201310124139.2  张偲，麦志茂，杨键，李洁，钱雪桥，尹团，张士忠

7. 一种丙酸杆菌及其在生产叶酸和烟酸中的应用，ZL 2017113052614张偲，李洁，陈志豪，尹团，钱雪桥

8. 一株产胞外多糖可固沙的溶杆菌SCSIO 17111及其应用，ZL 2018106095003，张偲，王琳，李洁

学科组建设

责任研究员：张偲

研究员：尹浩、王发左、李洁

助理研究员：麦志茂

博士后：陈煜

行政人员：李庆欣、郑怡聪

博士研究生：王琳（2016）、曾奇（2018）、邹易阳（2018）、李琦琦（2019）、丁文平（2019）

硕士研究生：琚慧敏（2017）

已培养博士研究生18名；硕士研究生6名