副研究员
-
姓名：吴华莲
-
性别：女
-
学历：博士
-
电子邮箱：hlwu@scsio.ac.cn
-
职称：
-
通讯地址：广州市海珠区新港西路164号
研究内容
藻种资源的分离与筛选、海藻天然产物生物活性评价及海藻资源的高值化开发与利用
教育经历
2007-09至2012-06，暨南大学，生物化学与分子生物学，博士
2003-09至2006-07，中国科学院南海海洋研究所，海洋生物学，硕士
1999-09至2003-07，东北师范大学，生物科学，学士
2003-09至2006-07，中国科学院南海海洋研究所，海洋生物学，硕士
1999-09至2003-07，东北师范大学，生物科学，学士
工作经历
2018-12-至今，中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室，项目副研究员
2012-07至2018-12，中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室，助理研究员
2012-07至2018-12，中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室，助理研究员
主持项目
1.蓝菌藻抗肿瘤活性多糖组分的挖掘及基于转录组学的机制研究，主持，广东省自然科学基金面上项目，2023年-2025年
2.广东特色海洋生物制品共性关键技术研发及产业应用-任务，主持，广东省重点领域研发计划重点专项-任务， 2020年-2023年
3.藻蓝蛋白及海水螺旋藻综合开发产业链协同创新与应用示范项目-课题，主持，“十三五”海洋经济创新发展示范（北海市）专项-课题，2017年-2021年
4.菱形藻的培养及积累岩藻黄素的调控机制的探讨，主持，国家自然科学基金青年科学基金项目，2015年-2017年
5.富含岩藻黄素极端微藻的筛选及岩藻黄素体外抗糖尿病活性评价研究，主持，中国科学院南海海洋研究所青年人才领域前沿项目，2012年-2015年
2.广东特色海洋生物制品共性关键技术研发及产业应用-任务，主持，广东省重点领域研发计划重点专项-任务， 2020年-2023年
3.藻蓝蛋白及海水螺旋藻综合开发产业链协同创新与应用示范项目-课题，主持，“十三五”海洋经济创新发展示范（北海市）专项-课题，2017年-2021年
4.菱形藻的培养及积累岩藻黄素的调控机制的探讨，主持，国家自然科学基金青年科学基金项目，2015年-2017年
5.富含岩藻黄素极端微藻的筛选及岩藻黄素体外抗糖尿病活性评价研究，主持，中国科学院南海海洋研究所青年人才领域前沿项目，2012年-2015年
科研成果
发表论文
[1] Na Wang #, Haiwei Pei#, Wenzhou Xiang, Tao Li, Shengjie Lin, Jiayi Wu, Zishuo Chen, Houbo Wu, Chuanmao Li, Hualian Wu*. Rapid screening of microalgae as potential sources of natural antioxidants. Foods, 2023, 12(14): 2652.
[2] Zishuo Chen#, Li Tan#, Bingjie Yang#, Jiayi Wu, Tao Li, Houbo Wu, Hualian Wu*, Wenzhou Xiang*. A mutant of seawater Arthrospira platensis with high polysaccharides production induced by space environment and its application potential. Algal Research, 2022, 61: 102562.
[3] Na Wang, Lumei Dai, Zishuo Chen, Tao Li, Jiayi Wu, Houbo Wu, Hualian Wu*, Wenzhou Xiang*. Extraction optimization, physicochemical characterization and antioxidant activity of polysaccharides from Rhodosorus sp. SCSIO-45730. Journal of Applied Phycology, 2022, 34: 285-299.
[4] Hualian Wu, Tao Li, Jinting Lv, Zishuo Chen, Jiayi Wu, Na Wang, Houbo Wu and Wenzhou Xiang*. Growth and Biochemical Composition Characteristics of Arthrospira platensis Induced by Simultaneous Nitrogen Deficiency and Seawater-Supplemented Medium in an Outdoor Raceway Pond in Winter. Foods, 2021, 10: 2974.
[5] Min Guo#, Ruilin Zheng#, Hua-Lian Wu#, Danyang Chen , Jingyao Su,Tiantian Xu, Houbo Wu, Wenzhou Xiang, Yinghua Li*, Bing Zhu*.Inhibition of enterovirus 71 infection by polysaccharides extracted from Picochlorum sp. 122 via the AKT and ATM/ATR signaling pathways. Archives of Virology, 2021, 166: 3269-3274.
[6] Hualian Wu＃, Xiaoyan Fu＃, Wenqiang Cao, Wenzhou Xiang, Yajun Hou, Jinkui Ma, Wang Ying*, Fan Cundong*, Induction of Apoptosis in Human Glioma Cells by Fucoxanthin via Triggering of ROS-Mediated Oxidative Damage and Regulation of MAPKs and PI3K-AKT Pathways. Journal of Agricultural and Food Chemistry, 2019, 67(8): 2212-2219.
[7] Wu Hualian, Li Tao, Wang Guanghua, Dai Shikun, He Hui, Xiang Wenzhou, A comparative analysis of fatty acid composition and fucoxanthin content in six Phaeodactylum tricornutum strains from diff erent origins, Chinese Journal of Oceanology and Limnology, 2016, 34(2): 391-398.
[8] Hualian Wu, Guang-Hua Wang, Wen-Zhou Xiang*, Tao Li & Hui He, Stability and Antioxidant Activity of Food-Grade Phycocyanin Isolated from Spirulina platensis, International Journal of Food Properties, 2016, 19: 2349-2362.
[9] Tianqi Nie＃, Hualian Wu＃, Ka-Hing Wong, Tianfeng Chen*, Facile synthesis of highly uniform selenium nanoparticles using glucose as the reductant and surface decorator to induce cancer cell apoptosis. Journal of Materials Chemistry B, 2016, 4: 2351-2358.
[10] Wei Huang＃, Hualian Wu＃, Xiaoling Li*, Tianfeng Chen*, Facile one-pot synthesis of tellurium nanorods as antioxidant and anticancer agents. Chemistry-An Asian Journal, 2016, 11:2301-11.
[11] Hualian Wu, Huili Zhu, Xiaoling Li, Zumei Liu, Wenjie Zheng*, Tianfeng Chen, Bo Yu, Ka-Hing Wong*, Induction of Apoptosis and Cell Cycle Arrest in A549 Human Lung Adenocarcinoma Cells by Surface-Capping Selenium Nanoparticles: An Effect Enhanced by Polysaccharide–Protein Complexes from Polyporus rhinoceros, Journal of Agricultural and Food Chemistry, 2013, 61 (41): 9859-9866.
[12] Hualian Wu; Xiaoling Li; Wen Liu; Tianfeng Chen*; Yinghua Li; Wenjie Zheng; Cornelia Wing-Yin Man; Man-Kin Wong*; Ka-Hing Wong, Surface decoration of selenium nanoparticles by mushroom polysaccharides-protein complexes to achieve enhanced cellular uptake and antiproliferative activity, Journal of Materials Chemistry, 2012, 22(19): 9602-9610.
[13 ]吴华莲，陈填烽，尹希，郑文杰. 硒对钝顶螺旋藻氧化损伤的拮抗作用的光谱学特性及机制. 光谱学与光谱分析. 2012, 32 (3): 749-754. (SCI收录)
专利
[1] 向文洲，李涛，吴华莲，吴嘉仪，陈子硕，刘德海，杨登亮，林盛杰，张楚标，陈浩. High-quality seawater spirulina obtained by space breeding, and use thereof，2021-6-1，美国发明专利，US11021684B2.
[2] 陈填烽，黄家兴，吴华莲，郑文杰，Man Kim Wong，Wing Yin Cornelia Man. Pleurotus Tuber-Regium Polysaccharide functionalized nano-selenium hydrosol with anti-tumor activity and preparation method thereof，2015-7-7，美国发明专利，US9072669B2.
[3] 吴华莲，向文州，李涛，吴嘉仪，吴后波. 一株联产γ-氨基丁酸和积雪草酸的克里藻及其用途，中国发明专利，ZL202210420496.2.
[4] 向文洲，杨芳芳，陈程浩，李涛，吴华莲，戴世鲲，范洁伟，刘德海，林盛杰，杨登亮，吕平平，钱茜茜. 一种培养海藻的方法，中国发明专利，ZL201611248970.9.
[5] 向文洲，谭丽，李涛，吴华莲，吴嘉仪，刘德海，杨登亮，吴泽宏，张伟杰，张楚标. 一株通过太空育种获得的高品质海水螺旋藻及其用途，中国发明专利，ZL201711461143.2.
[6] 张峰，向文洲，吴华莲，何慧，萧邶，叶永辉，范洁伟. 一种高pH诱导、耦合二氧化碳减排的海藻采收新方法，中国发明专利，ZL 201210585917.3.
[7] 李涛，向文洲，吴华莲，吴后波. 一种紫球藻浓缩采收的方法及紫球藻培养与浓缩采收相耦合的方法，中国发明专利，ZL 201810524457.0.
[8] 李涛，向文洲，吴华莲，吴后波. 一种紫球藻的两步培养法，中国发明专利, ZL 201810524456.6.
[9] 郑文杰，吴华莲，杨芳，刘杰. 蔗糖分子偶和的纳米单质碲水溶胶的制备方法，ZL 200810219521.0.
学术奖励
[1] 李传茂，向文洲，林盛杰，吴华莲，李涛，杨登亮，李华真，邓慧. 海藻功能性化妆品的应用研究与开发，2020年广东省轻工业联合会科学技术进步奖二等奖.
[2] 杨登亮，向文洲，李传茂，吴华莲，李涛，林盛杰. 富含天然活性成分的海藻株的优选及在功效型化妆品的应用，2021年中国轻工业联合会科学技术进步奖三等奖.
[1] Na Wang #, Haiwei Pei#, Wenzhou Xiang, Tao Li, Shengjie Lin, Jiayi Wu, Zishuo Chen, Houbo Wu, Chuanmao Li, Hualian Wu*. Rapid screening of microalgae as potential sources of natural antioxidants. Foods, 2023, 12(14): 2652.
[2] Zishuo Chen#, Li Tan#, Bingjie Yang#, Jiayi Wu, Tao Li, Houbo Wu, Hualian Wu*, Wenzhou Xiang*. A mutant of seawater Arthrospira platensis with high polysaccharides production induced by space environment and its application potential. Algal Research, 2022, 61: 102562.
[3] Na Wang, Lumei Dai, Zishuo Chen, Tao Li, Jiayi Wu, Houbo Wu, Hualian Wu*, Wenzhou Xiang*. Extraction optimization, physicochemical characterization and antioxidant activity of polysaccharides from Rhodosorus sp. SCSIO-45730. Journal of Applied Phycology, 2022, 34: 285-299.
[4] Hualian Wu, Tao Li, Jinting Lv, Zishuo Chen, Jiayi Wu, Na Wang, Houbo Wu and Wenzhou Xiang*. Growth and Biochemical Composition Characteristics of Arthrospira platensis Induced by Simultaneous Nitrogen Deficiency and Seawater-Supplemented Medium in an Outdoor Raceway Pond in Winter. Foods, 2021, 10: 2974.
[5] Min Guo#, Ruilin Zheng#, Hua-Lian Wu#, Danyang Chen , Jingyao Su,Tiantian Xu, Houbo Wu, Wenzhou Xiang, Yinghua Li*, Bing Zhu*.Inhibition of enterovirus 71 infection by polysaccharides extracted from Picochlorum sp. 122 via the AKT and ATM/ATR signaling pathways. Archives of Virology, 2021, 166: 3269-3274.
[6] Hualian Wu＃, Xiaoyan Fu＃, Wenqiang Cao, Wenzhou Xiang, Yajun Hou, Jinkui Ma, Wang Ying*, Fan Cundong*, Induction of Apoptosis in Human Glioma Cells by Fucoxanthin via Triggering of ROS-Mediated Oxidative Damage and Regulation of MAPKs and PI3K-AKT Pathways. Journal of Agricultural and Food Chemistry, 2019, 67(8): 2212-2219.
[7] Wu Hualian, Li Tao, Wang Guanghua, Dai Shikun, He Hui, Xiang Wenzhou, A comparative analysis of fatty acid composition and fucoxanthin content in six Phaeodactylum tricornutum strains from diff erent origins, Chinese Journal of Oceanology and Limnology, 2016, 34(2): 391-398.
[8] Hualian Wu, Guang-Hua Wang, Wen-Zhou Xiang*, Tao Li & Hui He, Stability and Antioxidant Activity of Food-Grade Phycocyanin Isolated from Spirulina platensis, International Journal of Food Properties, 2016, 19: 2349-2362.
[9] Tianqi Nie＃, Hualian Wu＃, Ka-Hing Wong, Tianfeng Chen*, Facile synthesis of highly uniform selenium nanoparticles using glucose as the reductant and surface decorator to induce cancer cell apoptosis. Journal of Materials Chemistry B, 2016, 4: 2351-2358.
[10] Wei Huang＃, Hualian Wu＃, Xiaoling Li*, Tianfeng Chen*, Facile one-pot synthesis of tellurium nanorods as antioxidant and anticancer agents. Chemistry-An Asian Journal, 2016, 11:2301-11.
[11] Hualian Wu, Huili Zhu, Xiaoling Li, Zumei Liu, Wenjie Zheng*, Tianfeng Chen, Bo Yu, Ka-Hing Wong*, Induction of Apoptosis and Cell Cycle Arrest in A549 Human Lung Adenocarcinoma Cells by Surface-Capping Selenium Nanoparticles: An Effect Enhanced by Polysaccharide–Protein Complexes from Polyporus rhinoceros, Journal of Agricultural and Food Chemistry, 2013, 61 (41): 9859-9866.
[12] Hualian Wu; Xiaoling Li; Wen Liu; Tianfeng Chen*; Yinghua Li; Wenjie Zheng; Cornelia Wing-Yin Man; Man-Kin Wong*; Ka-Hing Wong, Surface decoration of selenium nanoparticles by mushroom polysaccharides-protein complexes to achieve enhanced cellular uptake and antiproliferative activity, Journal of Materials Chemistry, 2012, 22(19): 9602-9610.
[13 ]吴华莲，陈填烽，尹希，郑文杰. 硒对钝顶螺旋藻氧化损伤的拮抗作用的光谱学特性及机制. 光谱学与光谱分析. 2012, 32 (3): 749-754. (SCI收录)
专利
[1] 向文洲，李涛，吴华莲，吴嘉仪，陈子硕，刘德海，杨登亮，林盛杰，张楚标，陈浩. High-quality seawater spirulina obtained by space breeding, and use thereof，2021-6-1，美国发明专利，US11021684B2.
[2] 陈填烽，黄家兴，吴华莲，郑文杰，Man Kim Wong，Wing Yin Cornelia Man. Pleurotus Tuber-Regium Polysaccharide functionalized nano-selenium hydrosol with anti-tumor activity and preparation method thereof，2015-7-7，美国发明专利，US9072669B2.
[3] 吴华莲，向文州，李涛，吴嘉仪，吴后波. 一株联产γ-氨基丁酸和积雪草酸的克里藻及其用途，中国发明专利，ZL202210420496.2.
[4] 向文洲，杨芳芳，陈程浩，李涛，吴华莲，戴世鲲，范洁伟，刘德海，林盛杰，杨登亮，吕平平，钱茜茜. 一种培养海藻的方法，中国发明专利，ZL201611248970.9.
[5] 向文洲，谭丽，李涛，吴华莲，吴嘉仪，刘德海，杨登亮，吴泽宏，张伟杰，张楚标. 一株通过太空育种获得的高品质海水螺旋藻及其用途，中国发明专利，ZL201711461143.2.
[6] 张峰，向文洲，吴华莲，何慧，萧邶，叶永辉，范洁伟. 一种高pH诱导、耦合二氧化碳减排的海藻采收新方法，中国发明专利，ZL 201210585917.3.
[7] 李涛，向文洲，吴华莲，吴后波. 一种紫球藻浓缩采收的方法及紫球藻培养与浓缩采收相耦合的方法，中国发明专利，ZL 201810524457.0.
[8] 李涛，向文洲，吴华莲，吴后波. 一种紫球藻的两步培养法，中国发明专利, ZL 201810524456.6.
[9] 郑文杰，吴华莲，杨芳，刘杰. 蔗糖分子偶和的纳米单质碲水溶胶的制备方法，ZL 200810219521.0.
学术奖励
[1] 李传茂，向文洲，林盛杰，吴华莲，李涛，杨登亮，李华真，邓慧. 海藻功能性化妆品的应用研究与开发，2020年广东省轻工业联合会科学技术进步奖二等奖.
[2] 杨登亮，向文洲，李传茂，吴华莲，李涛，林盛杰. 富含天然活性成分的海藻株的优选及在功效型化妆品的应用，2021年中国轻工业联合会科学技术进步奖三等奖.
获得荣誉
社会兼职