海洋微生物先导药物和新型功能酶的发掘与应用
1）具有抗菌、抗肿瘤、杀虫等海洋微生物活性天然产物的发现与应用
海洋来源微生物，因其特殊的生长环境，具有生产结构多样先导药物的潜力。如何运用独到的眼光将其发掘出来，并造福于社会，值得研究。
2）微生物新颖活性物质合成酶的发现与应用
海洋微生物因具有生产新型先导药物的基因，造就了其功能特殊的酶，发现、研究其催化机理，将其应用于社会的生产和生活，充满挑战且富有乐趣。

2008-09--2011-06   中山大学  化学生物学专业 理学博士
2005-09--2008-06   大连海洋大学   水产品加工与贮藏工程 工学硕士
2001-09--2005-06   河南农业大学   食品科学与工程 工学学士

2013.12-今，中国科学院南海海洋研究所，中科院热带海洋生物资源与生态重点实验室，副研究员。期间于2017.04-2018.04，在加大大学洛杉矶分校（University of California, Los Angeles/UCLA），化学与生物化学系(Department of Chemistry & Biochemistry)，CAS-UCLA联合培养公派在Prof. Yi Tang课题组做访问学者。
2011.07-2013.12，中国科学院南海海洋研究所，中科院热带海洋生物资源与生态重点实验室，助理研究员。

1. 国家自然科学基金面上项目，基因组学指导下深海真菌Penicillium sp. SCSIO sof101抗革兰氏阴性菌活性次级代谢产物的挖掘（22077128），2021.01-2024.12，主持。
2. 国家自然科学基金面上项目，以基因组信息为指导的深海放线菌SCSIO-5802次级代谢产物挖掘及其活性研究（41676151），2017.01-2020.12，主持。
3. 国家重点研发计划“绿色农药活性物质生物组合合成及合成生物技术研究”项目子课题：海洋微生物源活性代谢物库的构建（2017YFD0201401），2017.7-2020.12，主持。
4. 广州市科技计划项目，基于活性导向和液质排重下的海洋放线菌抗耐药性金黄色葡萄球菌（MRSA）活性物质的发现（201707010454），2017.05-2020.04，主持。
5. 主持广东省自然科学基金面上项目，深海放线菌Streptomyces sp. SCSIO 5604活性次级代谢产物的挖掘（2014A030313773），2015.01-2018.01，主持。
6. 主持国家自然科学基金青年基金，四株深海放线菌抗菌活性次级代谢产物的研究（41206135），2013.01-2015.12，主持。

论文
1.Yongxiang Song, Wengui Wang, Jiafan Yang, Dewei Gao, John M. Billingsley, Songtao Wang, Yiguang Zhu, Junfeng Wang, Jianhua Ju, Yan Yan* and Yi Tang, β-Terrecyclene Synthase Constructs the Quadrane Backbone in Terrecyclic Acid Biosynthesis, Chemical Science 2024, doi.org/10.1039/D4SC01208A. (一区top)
2.Jianfan Yang, Zhenbin. Zhou, Yingying Chen, Yongxiang Song,* Jianhua Ju*. Characterization of the depsidone gene cluster reveals etherification, decarboxylation and multiple halogenations as tailoring steps in depsidone assembly. Acta Pharmaceutica Sinica B 2023, 13, (9), 3919-3929. (共同通讯，一区top)
3.Xiaoyue Li, Wenbin Shen, Guochao Li, Yongxiang Song,* Xinhua Lu, Nao-Kei Wong, Yan Yan. Alternaphenol B2, a new IDH1 inhibitor from the coral-derived fungus Parengyodontium album SCSIO SX7W11. Natural Product Research 2023 18:1-7.
4.JiafanYang, Yongxiang Song,* Zhenbin Zhou, Yun Huang, Songtao Wang, Jie Yuan, Nai-Kei Wong, Yan Yan, Jianhua Ju*, Sulfoxanthicillin from the deep-sea derived Penicillium sp. SCSIO sof101: an antimicrobial compound against Gram-positive and -negative pathogens. Journal of Antibiotics (Tokyo) 2023, 76, (3), 113-120. (封面文章)
5.Jiafan Yang, Le Zhou, Zhenbin Zhou, Yongxiang Song* and J. Ju*. Anti-Pathogenic Depsidones and its Derivatives from a Coral-Derived Fungus Aspergillus Sp. SCSIO SX7S7. Biochemical Systematic and Ecology. 2022, 102, 104415
6.Qiong Lu, Liping Xu, Lin Liu, Yong Zhou, Tian Liu,* Yongxiang Song,* Jianhua Ju, Qing Yang. Lynamicin B is a Potential Pesticide by Acting as a Lepidoptera-Exclusive Chitinase Inhibitor. Journal of Agriculture and Food Chemistry 2021, 69(47),14086-14091. (* 共通讯，一区Top)
7.Jianfan Yang,# Yongxiang Song,#* Mancheng Tang, Mingzhe Li, Junwei Deng, Nai-Kei Wong and Jianhua Ju*. Genome-Directed Discovery of Tetrahydroisoquinolines from Deep-Sea Derived Streptomyces niveus SCSIO 3406. Journal of Organic Chemistry 2021. 86, (16), 11107-11116. (# 共一作，二区Top)
8.Run Xu,# Yongxiang Song,# Jun Li, Jianhua Ju, Qinglian Li*. Chemical Synthesis and Structure-Activity Relationship Study Yield Desotamide a Analogues with Improved Antibacterial Activity. Marine Drugs 2021, 19, 303-313. https://doi.org/10.3390/md19060303 （二区，IF：4.075 ）
9.Yongxiang Song, Jiafan Yang, Jianchen Yu, Jie Li, Jie Yuan, Nai-Kei Wong and Jianhua Ju*. Chlorinated bis-indole alkaloids from deep-sea derived Streptomyces sp. SCSIO 11791 with antibacterial and cytotoxic activities. Journal of Antibiotics (Tokyo) 2020, 73, 542-547. （IF：1.73）
10.宋永相, 张秀凤, 李艳芹, 肖华, 闫岩。自抗性基因导向的活性天然产物挖掘。合成生物学，2024，DOI: 10.12211/2096-8280.2023-099
11.宋永相*，李晓悦，鞠建华。深海放线菌Streptomyces koyangensis SCSIO 5802中次级代谢产物neoabyssomicin H的分离鉴定。热带海洋学报 2023，42 (3): 169-173.
12.Yanqin Li#, Mengjing Cong#, Wengui Wang, Xiufeng Zhang, Yiguang Zhu, Yongxiang Song, Wenjun Zhang, Hua Xiao, Yonghong Liu, Changsheng Zhang*, Junfeng Wang*, Yan Yan*. An Enzymatic Carbon-Carbon Bond Cleavage and Aldol Reaction Cascade Converts an Angular Scaffold into the Linear Tetracyclic Core of Ochraceopones. Angewandte Chemie International Edition 2024， doi.org/10.1002/anie.202403365. (一区top IF: 16.8)
13.Xiufeng Zhang, Xiaoyan Pang, Liping Zhang, Yanqin Li, Yongxiang Song, Hua Xiao, Yonghong Liu, Junfeng Wang* and Yan Yan*. Genome Mining Uncovers a Flavoenzyme-Catalyzed Isomerization Process during the Maturation of Pyrenophorol Dilactones. Organic Letters 2024, 26, 8, 1612-1617. (一区top IF: 6.1)
14.Hongbo Huang#, Yun Zhang#, Yongxiang Song, Chunyao Ling, Siyan Peng, Bo Ding, Yiwen Tao* and Jianhua Ju*. Deciphering the Glycosylation Steps in the Biosynthesis of P-1894B and Grincamycin Isolated from Marine-Derived Streptomyces lusitanus SCSIO LR32. Marine Drugs 2024, 22(1), 32-44. (二区IF: 5.4)
15.Yingying Chen, JiafanYang, Cunlei Cai, Junjie Shi, Yongxiang Song, Junying Ma, Jianhua Ju. Development of Marker Recycling Systems for Sequential Genetic Manipulation in Marine-Derived Fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7. J. Fungi 2023, 9, (3), 302-314.
16.Yingying. Chen, Cunlei. Cai, Jiafan Yang, Junjie Shi, Yongxiang Song, Dan Hu, Junying Ma*, Jianhua Ju*. Development of CRISPR-Cas9 system for the marine-derived fungi Spiromastix sp. SCSIO F190 and Aspergillus sp. SCSIO SX7S7. J. Fungi 2022, 8(7), 715.
17.Huaran Zhang, Yingying Chen, Yanqing Li, Yongxiang Song, Junying Ma and Jianhua Ju*. Secondary Metabolites and Biosynthetic Gene Clusters Analysis of Deep-Sea Hydrothermal Vent-Derived Streptomyces sp. SCSIO ZS0520. Mar. Drugs 2022, 20(6), 393.
18.Qinghua Zhu, Weige Cheng, Yongxiang Song, Qing He, Jianhua Ju, Qinglian Li*. Complete genome sequence of the deep South China Sea-derived Streptomyces niveus SCSIO 3406, the producer of cytotoxic and antibacterial marfuraquinocins. PLoS One 2021, 16, (3), e0248404.（三区, IF: 2.740）
19.周晓雪; 杨佳凡; 李明哲; 宋永相; 鞠建华; 李晓帆; 王立岩。珊瑚来源真菌Parengyodontium album SCSIO SX7W11中聚酮化合物的发现及其生物合成途径分析. 微生物学报 2021, 61, (11), 3631-3641.
20.Xiaoqi Ji, Jiajia Tu, Yongxiang Song, Chunyan Zhang, Liyan Wang, Qinglian Li,* and Jianhua Ju*. A Luciferase-Like Monooxygenase and Flavin Reductase Pair AbmE2/AbmZ Catalyzes Baeyer-Villiger Oxidation in Neoabyssomicin Biosynthesis. Acs Catalysis 2020, 10, (4), 2591-2595.
21.Danielle A. Yee, Thomas B. Kakule, Wei Cheng, Mengbin Chen, Christine T. Y.  Chong, Yang Hai, Leibniz Hang, Yiu-Sun Hung, Nicholas Liu, Masao Ohashi, Ikechukwu C. Okorafor, Yongxiang Song, Mancheng Tang, Zhuan Zhang, Yi Tang. Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway. Journal of American Chemistry Society 2020, 142, 710-714.
22.P. Kumar, C. Ling, Z. Zhou, Y. Dong, C. Sun, Y. Song, N. Wong, J. Ju. Chemical Diversity of Metabolites and Antibacterial Potential of Actinomycetes Associated with Marine Invertebrates from Intertidal Regions of Daya Bay and Nansha Islands. Microbiology 2020, 89, (4), 483-492.
专利
1.闫岩，宋永相。一种新骨架倍半萜terrecyclic acid的生物合成基因簇及其应用（申请日申请号2024101402513）。
2.宋永相，李晓悦，陈夏雨，邓音乐，闫岩，鞠建华。一类吡咯烷醇酸类化合物在制备抑制白色念珠菌致病性药物中的应用（申请号2023116805419）。
3.宋永相，杨佳凡，周镇槟，李晓悦，马俊英，闫岩，鞠建华。一类异腈基化合物及其制备方法和在制备抗菌药物中的应用。（授权专利号：202211386568）。
4.宋永相，杨佳凡，赖添财，鞠建华。深海放线菌生物制剂在制备预防柑橘溃疡疾病药物中的应用（2020.11.10授权专利号：202010048059.3）。
5.宋永相，鞠建华，刘田，李洁，杨佳凡，李晓悦，卢琼，杨青。深海放线菌11791在制备防治农牧业鳞翅目害虫药物中的应用（授权专利号：202111348237.5，已转化）
6.杨青，刘田，宋永相，卢琼，鞠建华。双吲哚吡咯类化合物的应用（授权专利号：202110493094.0，已转化）。
7.鞠建华，宋永相，杨佳凡。一类骨架新颖的6/6/6/6/5/5环生物碱类化合物及其在制备抗菌药物中的应用（2023.01.03授权专利号：202011087495.8）。
8.李青连，徐润，宋永相，李骏，鞠建华。一种环六肽化合物desotamide A4及其在制备抗菌药物中的应用（授权专利号：202110555444.1）
9.鞠建华，周镇槟，杨佳凡，宋永相，田新朋。两个大环内酯化合物及其在制备抗菌、抗癌药物中的应用。（授权专利号：202210128899.X）