致力于与人类健康密切相关海洋生物功能蛋白肽和多糖的发掘与利用关键技术研究，重点发掘肿瘤辅助治疗及肠道保护相关活性多糖和小分子肽。以活性物质特征结构与其作用机制关系等关键科学问题为研究目标，交叉融合天然产物化学、生物信息学、生物化学和药理学等多学科技术，构建活性肽特征序列的快速筛选技术，阐明活性肽特征氨基酸序列、糖链特征结构与营养健康效应及机制的关系，系统集成多用途高品质功能肽原料规模化定向制备成套技术，并应用创制系列新型高附加值海洋生物制品。联合企业共同研制多个海洋生物制品，包括营养食品2种，化妆品2个系列，部分食品和化妆品已上市销售，共计产生3.3亿元的经济效益，推动地方产业和经济的发展。

1997-2001 暨南大学-化学系-应用化学专业，学士；
2001-2004 暨南大学-化学系-分析化学方向，硕士；
2005-2008 中科院南海海洋研究所-海洋生物学方向，博士；

2008-2010 中国医学科学院-北京药用植物研究所-生药学方向，博士后；
2010-2011 中科院南海海洋研究所-海洋生物方向，助理研究员；
2011-2019 中科院南海海洋研究所-海洋生物方向，副研究员，硕导。
2020至今 中科院南海海洋研究所-海洋生物方向，研究员，硕导。

1.“海洋功能肽的高效制备技术及产品开发”，主持，国家重点研发计划课题，2018-07至2021-12。
2.“海洋软体动物功能蛋白肽制备及其应用示范”，主持，海洋经济创新发展区域示范专项课题，2013-01至2017-12。
3.“牡蛎活性肽的追踪分离及对肠道黏膜屏障的作用与机理研究”，主持，国家青年科学基金项目，2011-01至2014-12。
4.“牡蛎肽在胃肠功能障碍修复型肠内营养制品中的应用与示范”，主持，广东省中国科学院全面战略合作专项，2011-12至2013-11。

（1）研究论文：
[1]Cai, B., L. Luo, X. Zhao, H. Chen, P. Wan, J. Huang, D. Chen and J. Pan*. "Administration of Gracilariopsis lemaneiformis polysaccharide attenuates cisplatin-induced inflammation and intestinal mucosal damage in colon-26 carcinoma tumor-bearing mice." Journal of the Science of Food and Agriculture, 2024, 104(6): 3757-3766. DOI: 10.1002/jsfa.13260.
[2]Zhao, X., B. Cai, H. Chen, P. Wan, D. Chen, Z. Ye, A. Duan, X. Chen, H. Sun and J. Pan*. "Tuna trimmings (Thunnas albacares) hydrolysate alleviates immune stress and intestinal mucosal injury during chemotherapy on mice and identification of potentially active peptides." Current Research in Food Science, 2023, 7. DOI: 10.1016/j.crfs.2023.100547.
[3]Wan, P., B. Cai, H. Chen, D. Chen, X. Zhao, H. Yuan, J. Huang, X. Chen, L. Luo and J. Pan*. "Antidiabetic effects of protein hydrolysates from Trachinotus ovatus and identification and screening of peptides with ?-amylase and DPP-IV inhibitory activities." Current Research in Food Science, 2023, 6. DOI: 10.1016/j.crfs.2023.100446.
[4]Cai, B., X. Yi, Z. Wang, X. Zhao, A. Duan, H. Chen, P. Wan, D. Chen, J. Huang and J. Pan*. "Anti-fatigue effects and mechanism of Syngnathus schlegeli peptides supplementation on exercise-fatigued mice." Journal of Functional Foods, 2023, 110. DOI: 10.1016/j.jff.2023.105846.
[5]Cai, B., L. Luo, X. Chen, X. Zhao, J. He, H. Chen, P. Wan, D. Chen and J. Pan*. "Structural characterization of a sulfated polysaccharide from Gracilariopsis lemaneiformis and its potentiation of cisplatin antitumor activity in Colon-26 carcinoma tumor-bearing mice by inducing ferroptosis." Food & Function, 2023, 14(8): 3712-3721. DOI: 10.1039/d3fo00009e.
[6]Ye, Z., X. Zhao, B. Cai, P. Wan, H. Chen and J. Pan*. "Oyster hydrolysates alleviate 5-fluorouracil-induced intestinal mucosal injury on S180 tumor-bearing mice." Journal of Tropical Oceanography, 2022, 41(5): 105-116. DOI.
[7]Peng, B., B. Cai and J. Pan*. "Octopus-derived antioxidant peptide protects against hydrogen peroxide-induced oxidative stress in IEC-6 cells." Food Science & Nutrition, 2022, 10(11): 4049-4058. DOI: 10.1002/fsn3.3000.
[8]Cai, B., X. Zhao, L. Luo, P. Wan, H. Chen and J. Pan*. "Structural characterization, and in vitro immunostimulatory and antitumor activity of an acid polysaccharide from Spirulina platensis." International Journal of Biological Macromolecules, 2022, 196: 46-53. DOI: 10.1016/j.ijbiomac.2021.12.062.
[9]Cai, B., P. Wan, H. Chen, J. Huang, Z. Ye, D. Chen and J. Pan*. "Purification and Identification of Novel Myeloperoxidase Inhibitory Antioxidant Peptides from Tuna (Thunnas albacares) Protein Hydrolysates." Molecules, 2022, 27(9). DOI: 10.3390/molecules27092681.
[10]Cai, B., H. Chen, P. Wan, L. Luo, Z. Ye, J. Huang, D. Chen and J. Pan*. "Isolation and identification of immunomodulatory peptides from the protein hydrolysate of tuna trimmings (Thunnas albacares)." Lwt-Food Science and Technology, 2022, 164. DOI: 10.1016/j.lwt.2022.113614.
[11]Chen, D., P. Wan, B. Cai, Z. Ye, H. Chen, X. Chen, H. Sun and J. Pan*. "Trimethylamine Adsorption Mechanism on Activated Carbon and Removal in Water and Oyster Proteolytic Solution." Journal of Ocean University of China, 2021, 20(6): 1578-1586. DOI: 10.1007/s11802-021-4813-1.
[12]Cai, B., P. Wan, H. Chen, X. Chen, H. Sun and J. Pan*. "Identification of octopus peptide and its promotion of β-casein synthesis in a mouse mammary epithelial cell line." Journal of Food Biochemistry, 2020, 44(11). DOI: 10.1111/jfbc.13467.
[13]Pan, J., P. Wan, D. Chen, H. Chen, X. Chen, H. Sun and B. Cai. "Purification and identification of intestinal mucosal cell proliferation-promoting peptides from Crassostrea hongkongensis." European Food Research and Technology, 2019, 245(3): 631-642. DOI: 10.1007/s00217-018-3186-1.
[14]Cai, B., P. Wan, H. Chen, D. Chen, X. Chen, H. Sun and J. Pan*. "Composition characterization of oyster polysaccharides from Crassostrea hongkongensis and their protective effect against H2O2-induced oxidative damage in IEC-6 cells." International Journal of Biological Macromolecules, 2019, 124: 246-254. DOI: 10.1016/j.ijbiomac.2018.11.154.
[15]Cai, B., P. Wan, H. Sun, D. Chen, H. Chen, X. Chen and J. Pan*. "Protective Effects of Enteral Nutrition Supplemented with Crassostrea hongkongensis Polysaccharides Against 5-Fluorouracil-Induced Intestinal Mucosal Damage in Rats." Journal of Medicinal Food, 2018, 21(4): 348-355. DOI: 10.1089/jmf.2017.4025.
[16]Zhu, X., H. Chen, B. Cai, P. Wan, H. Sun, D. Chen and J. Pan*. "Production of bile acid salts binding hydrolysate from Trachinotus ovatus and its molecular weight distribution." South China Fisheries Science, 2017, 13(2): 101-108. DOI.
[17]Chen, D., X. Chen, H. Chen, B. Cai, P. Wan, X. Zhu, H. Sun, H. Sun and J. Pan*. "Identification of odor volatile compounds and deodorization of Paphia undulata enzymatic hydrolysate." Journal of Ocean University of China, 2016, 15(6): 1101-1110. DOI: 10.1007/s11802-016-3166-7.
[18]Cai, B., H. Chen, H. Sun, P. Wan, H. Sun and J. Pan*. "Production of immunoregulatory polysaccharides from Crassostrea hongkongensis and their positive effects as a nutrition factor in modulating the effectiveness and toxicity of 5-FU chemotherapy in mice." Food & Function, 2016, 7(1): 390-397. DOI: 10.1039/c5fo00885a.
[19]Wan, P., X. Yang, B. Cai, H. Chen, H. Sun, D. Chen and J. Pan*. "Ultrasonic extraction of polysaccharides from Laminaria japonica and their antioxidative and glycosidase inhibitory activities." Journal of Ocean University of China, 2015, 14(4): 651-662. DOI: 10.1007/s11802-015-2648-3.
[20]Cai, B., H. Chen, H. Sun, H. Sun, P. Wan, D. Chen and J. Pan*. "Lactogenic Activity of an Enzymatic Hydrolysate from Octopus vulgaris and Carica papaya in SD Rats." Journal of Medicinal Food, 2015, 18(11): 1262-1269. DOI: 10.1089/jmf.2014.3355.
[21]Wan, P., N. Ren, B. Cai, H. Chen, D. Chen, H. Sun and J. Pan*. "Study on extraction technique of taurine from Crassostrea hongkongensis with ultrasonic and enzymatic hydrolysis." Guangdong Agricultural Sciences, 2014, 41(20): 114-118. DOI.
[22]Cai, B., C. Chen, X. Chen, H. Sun, Y. Chen and J. Pan*. "Isolation and Purification of Antioxidative Polysaccharides from Spirulina platensis." Food Science, 2013, 34(23): 83-87. DOI.

（2）授权发明专利13件：
[1]一种卵形鲳鲹降血糖肽及其制备方法与应用，ZL202210280861.4
[2]一种金枪鱼蛋白来源的短肽、筛选及其应用，ZL202111652294.2
[3]一种可有效缓解皮肤晒伤的海藻提取物及其制备方法和应用，202210021156.2
[4]一种皮肤创伤修复海洋生物医用材料及其制备方法和应用，202111443001.X
[5]一种螺旋藻寡糖及其在制备调节肠道健康功能制剂中的应用，ZL 202011487323.X
[6]一种促进乳腺酪蛋白合成的章鱼寡肽及其制备方法与应用，ZL 201910608720.9
[7]一种促进肠黏膜上皮细胞增殖和迁移的寡肽及其制备方法和应用，ZL 201810327326.3
[8]一种降血脂的营养组合物及其应用，ZL 201610558034.1
[9]一种螺旋藻寡糖及其在制备调节肠道健康功能制剂中的应用，ZL 202011487323.X
[10]一种以虾蟹壳为原料的可再生重金属吸附材料及其制备方法和再生方法及应用，ZL 201510520008.5
[11]一种肠道黏膜保护与修复型肠内营养制品及其制备方法，ZL 201310437598.6
[12]一种用于妊娠糖尿病妇女的肠内营养制剂及其制备方法和用途，ZL 201310480995.1
[13]一种保护化疗损伤的肠黏膜屏障功能的肠内营养制剂，ZL 201310399203.8
[14]一种用于糖尿病患者的海洋生物型肠内营养制剂及其制备方法和用途，ZL 201210094430.5
[15]一种去除并抑制水产动物酶解液腥味的方法，ZL 201210107142.9
（3）申报发明专利9件：
[1]一种海洋生物酶解蛋白肽脱色制备方法，CN202311052535.9
[2]一种金枪鱼α-淀粉酶和二肽基肽酶-Ⅳ抑制寡肽及其制备方法与用途，CN202410159401.5
[3]一种金枪鱼降血糖肽及其制备方法与用途，CN202410159399.1
[4]一种缓解化疗药物对肠黏膜损伤且提高抑瘤率的低分子量牡蛎酶解物制备方法及其应用, CN 202111284462.7
[5]一种低分子量螺旋藻多糖及其制备方法和应用，V202111219785.8
[6]一种拮抗氧化应激损伤的章鱼抗氧化肽的制备方法和应用，CN 202111327747.4
[7]一种抑制髓过氧化物酶MPO的金枪鱼抗氧化肽的制备方法与应用，V202111329213.5
[8]一种可有效减轻皮肤晒伤的海洋生物活性肽及其制备方法和应用，CN 202110692920.4
[9]一种具有显著皮肤晒伤防护作用的海洋生物活性肽及其制备方法和应用，CN 202110691191.0
[10]一种促进皮肤创伤修复的海洋生物肽及其制备方法和应用，CN202211054484.9
[11]缓解化疗诱导的免疫应激和肠黏膜损伤金枪鱼肽的制备方法与应用，202211046606.X
（4）软件版权1件：
[1]活性肽特征氨基酸序列筛选软件[简称：CarSeq-Filter]V1.0，2020SR0126519

[1]2020年度广东省科技进步奖二等奖（第一完成人），“南海特色海洋生物活性肽关键技术开发与产业化应用”。
[2]2018年第十届国际发明展览会金奖（第四完成人），“一种具有护唇、美唇功效的蜂毒组合物”

[1]广东省食品安全学会副秘书长；
[2]广东省食品学会常务理事，海洋食品专业委员会委员；
[3]广东省特医食品产业技术创新联盟理事会理事；
[4]广东省毒理学会理事；
[5]广东海洋协会，海洋生物分会副秘书长。