研究生培养
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所系名称 |
中国科学院南海海洋研究所，中国科学院热带海洋生物资源与生态重点实验室 | ||||
性别 |
男 | ||||
专业名称 |
生物与医药 | ||||
技术职务 |
研究员 | ||||
行政职务 |
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Mail地址 |
wzhang@scsio.ac.cn | ||||
指导博士生总数 |
0 |
指导硕士生总数 |
2 |
通讯地址 |
广州市新港西路164号标本楼403 |
目前博士生数 |
0 |
目前硕士生数 |
2 |
邮政编码 |
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研究方向 |
海洋微生物代谢工程与生物合成研究。 |
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研究工作 |
主要从事海洋微生物活性次级代谢产物的发现、生物合成和抗感染、抗肿瘤创新药物研发工作。目前主持国家自然基金面上项目2项，广东省科技项目1项，中国科学院前沿科学重点研究项目(子课题）1项。在研究领域核心期刊（Angew. Chem. Int. Ed.、Chem Sci、Org. lett.、J. Nat. Prod.、ChemBioChem）发表论文10篇，论文被 Faculty of 1000，Natural Product Report或Global Medical Discovery等作为研究亮点评述。 | ||||
获奖情况 |
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指导研究生情况 |
硕士研究生：徐慧欣（2018级）、王璐（2019级） | ||||
个人简介 |
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科研成果 |
论文成果（#为共同第一作者，*为通讯作者） 1. Zhang W#; Yang, C#.; Huang, C.; Zhang, L.; Zhang, H.; Zhang, Q.; Yuan, C.-S.; Zhu, Y.; Zhang, C*., Pyrazolofluostatins A–C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160. Org Lett, 2017, 19, 592-595. 2. Saha, S#.; Zhang, W#.; Zhang, G#.; Zhu, Y.; Chen, Y.; Liu, W.; Yuan, C.; Zhang, Q.; Zhang, H.; Zhang, L.; Zhang, W.; Zhang, C*., Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams. Chem Sci.2017, 8, 1607-1612. 3. Yang C, Huang C, Zhang W*, Zhu Y, Zhang C*, Heterologous Expression of Fluostatin Gene Cluster Leads to a Bioactive Heterodimer, Org Lett, 2015, 17 (21): 5324-5327. 4. Zhu Y#, Zhang W#, Chen Y, Yuan CS, Zhang H, Zhang G, Ma L, Zhang Q,Tian X, Zhang S,Zhang C*. Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds,Chembiochem,2015, 16 (14): 2086-2093. 5. Zhang G#, Zhang W#, Zhang Q, Shi T, Ma L, Zhu Y, Li S, Zhang H, Zhao YL, ShiR, Zhang C* Mechanistic Insights into Polycycle Formation by Reductive Cyclization in Ikarugamycin Biosynthesis, Angew Chem Int Ed Engl., 2014, 53 (19): 4840-4844. 6. Chen Y#, Zhang W#, Zhu Y*, Zhang Q, Tian X, Zhang S, Zhang C* Elucidating Hydroxylation andMethylation Steps Tailoring Piericidin A1 Biosynthesis, Org Lett, 2014, 16, 736-739 7. Zhang W, Ma L, Li S, Liu Z, Chen Y, Zhang HB, Zhang G, Zhang Q, Tian X, Yuan C, Zhang S, Zhang W, Zhang C* Indimicins A–E, Bisindole Alkaloids from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032, J Nat Prod,2014, 77 (8): 1887-1892. 8. Zhang W, Li S, Zhu Y, Chen YC, Chen YL, Zhang HB, Zhang G, Tian X, Pan Y, Zhang S, Zhang WM, Zhang C*. Heronamides D–F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp. SCSIO 03032, J Nat Prod, 2014, 77 (2): 388-391. 9. Zhang W, Liu Z, Li S, Yang T, Zhang Q, Ma L, Tian X, Zhang H, Huang C, Zhang S, Ju J, Shen Y, Zhang C*. Spiroindimicins A–D: New Bisindole Alkaloids from a Deep-Sea-Derived Actinomycete, Org Lett,2012, 14 (13): 3364-3367. 10. Zhang W#, Liu Z#, Li S, Lu Y, Chen Y, Zhang H, Zhang G, Zhu Y, Zhang G, Zhang W, Liu J, Zhang C* Fluostatins I–K from the South China Sea-Derived Micromonospora rosaria SCSIO N160, J Nat Prod, 2012, 75 (11): 1937-1943. |
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